Biosynthesis Of Ergot Alkaloids And Related Compounds

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Biosynthesis Of Ergot Alkaloids And Related Compounds

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Author : Heinz C. Floss
language : en
Publisher: Elsevier Science & Technology
Release Date : 1976

Biosynthesis Of Ergot Alkaloids And Related Compounds written by Heinz C. Floss and has been published by Elsevier Science & Technology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Alkaloids categories.

Ergot Alkaloids

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Author : Zdeněk Řeháček
language : en
Publisher: Elsevier Publishing Company
Release Date : 1990

Ergot Alkaloids written by Zdeněk Řeháček and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.

This monograph reflects the continued and growing interest in ergot alkaloids due to their fascinating chemistry, multiple biological actions, their importance as therapeutically useful agents and the innovation of alkaloid biotechnology. As well as giving a brief review of recent literature, the book also illustrates the present problems of ergot research with emphasis on areas where knowledge is lacking and where research should be pursued further. It is hoped that the book will also stimulate integration of the individual fields of ergot alkaloid research. Its usefulness is enhanced by the inclusion of many illustrations, graphs, tables and over 700 references. The book is intended for advanced undergraduates in biochemistry and molecular biology, for graduates embarking upon studies of excessive metabolites of microorganisms, for chemists seeking to find some understanding of the more biological aspects of the subject, for biologists who require some knowledge of the chemical and molecular aspects, and for practitioners in bioindustry. The book is also helpful as a bibliographic source.

Ergot

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Author : Vladimir Kren
language : en
Publisher: CRC Press
Release Date : 1999-04-08

Ergot written by Vladimir Kren and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-08 with Health & Fitness categories.

This volume provides readers with biotechnological aspects of ergot alkaloid production and genetic and physiological data. Toxicology and environmental risks of ergot infection and contamination of food and forage are also detailed

Synthetic Studies Of Compounds Structurally Related To The Ergot Alkaloids

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Author : A. L. Glenn
language : en
Publisher:
Release Date : 1952

Synthetic Studies Of Compounds Structurally Related To The Ergot Alkaloids written by A. L. Glenn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1952 with categories.

Recent Investigations Of Ergot Alkaloids Incorporated Into Plant And Or Animal Systems

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Author : Darrin Smith
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-01

Recent Investigations Of Ergot Alkaloids Incorporated Into Plant And Or Animal Systems written by Darrin Smith and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-01 with Biology (General) categories.

Ergot alkaloids produced by fungi have a basic chemical structure but different chemical moieties at substituent sites result in various forms of alkaloids that are distinguishable from one another. Since the ergoline ring structure found in ergot alkaloids is similar to that of biogenic amines (neurotransmitters), a variety of physiological effects can result after ingestion. Research involving ergot alkaloids is an increasing important global issue as more governments pass laws that limit permissible levels of ergot alkaloids in both foodstuffs and feedstuffs. Regardless of whether these compounds are found directly in foodstuffs or in feed/plants given to forage animals (i.e., cattle, horses, sheep, and goats), introduction of these compounds can complicate the food supply. In addition, toxicosis resulting from alkaloids can be a costly hindrance, with mounting annual production losses associated with forage-animal production systems that impact other agricultural and food based industries. Recent advances for the analysis of these compounds in different matrices as well as the understanding the role these compounds play in distinct biological pathways have begun to help address the issue. This Research Topic “Recent Investigations of Ergot Alkaloids Incorporated into Plant and/or Animal Systems“ has developed a novel platform where different groups share recent data in their investigations with ergot alkaloids. The presented collection of articles emphasizes the complexity of this issue and the multiple approaches necessary to resolve the global ergot alkaloid challenges.

Fungal Metabolites

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Author : Jean-Michel Mérillon
language : en
Publisher:
Release Date :

Fungal Metabolites written by Jean-Michel Mérillon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Fungi categories.

Ergot Alkaloids And Related Compounds

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Author : B. Berde
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Ergot Alkaloids And Related Compounds written by B. Berde and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

With contribution by numerous experts

Nature S Approach Toward Ring Formation And Structural Diversity In Ergot Alkaloid Biosynthesis

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Author : Johnathan Zandrew Cheng
language : en
Publisher:
Release Date : 2011

Nature S Approach Toward Ring Formation And Structural Diversity In Ergot Alkaloid Biosynthesis written by Johnathan Zandrew Cheng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.

Ergot alkaloids are fungal-derived secondary metabolites well known for a diverse array of pharmacological effects both beneficial and detrimental to human health. Historically, the ergot alkaloids have been known to cause ergotism in populations that consume grain contaminated by ergot alkaloid producing fungus. However, naturally isolated and semi-synthetic derivatives of certain ergot alkaloids have also been used to treat migraines, Parkinsonism, and tumor growth. Different fungal species such as Aspergillusfumigatus, Claviceps purpurea, and Neotyphodium lolii produce ergot alkaloids that have distinct structural features yet share a common tetracyclic ergoline ring scaffold. Mechanistic details regarding the formation of the common ergoline ring are not well understood, though the genes encoding the enzymes that carry out these cyclizations are believed to be well conserved across divergent fungal species. Here we describe in vivo gene disruption experiments in Aspergillusfumigatus that allowed us to identify candidate enzymes that were directly involved with the intramolecular cyclization of the ergoline ring. Additionally, we discuss the cloning and heterologous expression of these genes to further characterize their catalytic function. Old Yellow Enzyme homologues from the ergot gene clusters of Aspergillus fumigatus and Neotyphodium loii were shown to catalyze the formation of the D ring of the ergoline skeleton. These enzymes catalyzed either reductase or isomerase type reactions to yield distinct pathway intermediates. Mutational analysis was used to engineer an Old Yellow Enzyme that displayed both reductase and isomerase activities, thereby elucidating the mechanistic basis behind this switch in enzymatic activity. These findings present a mechanistic rationale behind nature's biosynthetic strategy toward ring cyclization and the introduction of structural diversity into the ergot alkaloid class of natural products.

Alkaloid Synthesis

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Author : Hans-Joachim Knoelker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-13

Alkaloid Synthesis written by Hans-Joachim Knoelker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-13 with Science categories.

Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-

Ergot Alkaloids And Their Biosynthesis

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Author : Z. Rehacek
language : en
Publisher:
Release Date : 1980

Ergot Alkaloids And Their Biosynthesis written by Z. Rehacek and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with categories.