Biotherapeutic Agents And Infectious Diseases

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Biotherapeutic Agents And Infectious Diseases

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Author : Gary W. Elmer
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-01-07

Biotherapeutic Agents And Infectious Diseases written by Gary W. Elmer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-07 with Medical categories.

Authoritative investigators active in the discovery, development, and application of biological anti-infective agents concisely review their use and potential in preventing and treating human disease. Focusing on biotherapeutic entities that have been tested in controlled studies, the prominent experts illuminate the scientific underpinnings of their therapeutic power, assess their possible risks in the treatment of infectious diseases, and outline the research needed to better define their effectiveness. In addition, they also consider how biotherapeutic agents may be genetically engineered for maximum intestinal and vaginal production of bioactive substances in vivo. Biotherapeutic Agents and Infectious Diseases brings together all the evidence needed to understand and capitalize on the considerable promise of this significant new class of biotherapeutic entities.

Bugs As Drugs

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Author : Robert A. Britton
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-02

Bugs As Drugs written by Robert A. Britton and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-02 with Medical categories.

Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

Pharmacotherapy Of Gastrointestinal Inflammation

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Author : Antonio Guglietta
language : en
Publisher: Springer
Release Date : 2012-12-06

Pharmacotherapy Of Gastrointestinal Inflammation written by Antonio Guglietta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

In recent years, the area of pharmacotherapy of GI inflammation has witnessed important progress, with new drugs and therapeutic approaches being introduced. The volume reviews the pharmacotherapy of selected gastrointestinal inflammatory conditions chosen on the basis of their clinical importance and/or the areas where important and exciting progress has been made recently. Besides discussing current pharmacotherapy to treat the most important GI inflammation conditions, the book also indicates possible future therapeutic avenues likely to become available in a few years. The book is of interest to various sectors of the scientific community ranging from clinicians to pharmacologists and from biochemists to microbiologists, who will find it a useful tool for their clinical practice and research activity.

The Power Of Probiotics

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Author : Gary W. Elmer
language : en
Publisher: Routledge
Release Date : 2013-12-19

The Power Of Probiotics written by Gary W. Elmer and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-19 with Health & Fitness categories.

Get information you can trust to make the right decisions about probiotics The Power of Probiotics is a consumer-friendly guide to the selection and use of probiotics that have been proven effective in the prevention and treatment of human diseases. This jargon-free reference resource provides practical advice on how and when to use probiotics and how to select the best commercially available products, based on usefulness, quality, and safety, to lower the risk of disease and maintain a positive health image. The book offers objective information on evaluating product claims, making sense of regulations and labeling, and sorting through manufacturing and marketing issues. The Power of Probiotics presents an expert review of the scientific evidence for probiotics, illustrated with summary tables and diagrams for quick reference. Each chapter starts with a series of FAQs with clear and concise answers before moving into more in-depth analysis from the book’s authors, who combine more than 20 years of research from the patient clinic and the bench laboratory with extensive experience in writing and translating medical articles for consumer-oriented publications. This unique book presents definitions and descriptions of probiotics and a history of their uses, a review of medical conditions prevented and/or treated by probiotics, available products (with brand names), uses with other medications, and risks and side effects. The Power of Probiotics examines the treatment and/or prevention of: allergies cancer colds and flu constipation dental health diarrhea high cholesterol indigestion inflammatory bowel diseases pseudomembranous colitis stomach ulcers stress urinary tract infections vaginal infections weight loss and much more! The Power of Probiotics is an essential resource for health-conscious consumers who are interested in natural alternatives to conventional medicines. Health professionals, educators, and students will also benefit from the book’s extensive references.

Ending The War Metaphor

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2006-07-09

Ending The War Metaphor written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-09 with Medical categories.

Infectious diseases have existed longer than us, as long as us, or are relatively newer than us. It may be the case that a disease has existed for many, many years but has only recently begun affecting humans. At the turn of the century the number of deaths caused by infections in the United States had been falling steadily but since the '80s has seen an increase. In the past 30 years alone 37 new pathogens have been identified as human disease threats and 12% of known human pathogens have been classified as either emerging or remerging. Whatever the story, there is currently a "war" on infectious diseases. This war is simply the systematic search for the microbial "cause" of each disease, followed by the development of antimicrobial therapies. The "war" on infectious diseases, however, must be revisited in order to develop a more realistic and detailed picture of the dynamic interactions among and between host organisms and their diverse populations of microbes. Only a fraction of these microbes are pathogens. Thus, in order to explore the crafting of a new metaphor for host-microbe relationships, and to consider how such a new perspective might inform and prioritize biomedical research, the Forum on Microbial Threats of the Institute of Medicine (IOM) convened the workshop, Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship on March 16-17, 2005. Workshop participants examined knowledge and approaches to learning about the bacterial inhabitants of the human gut, the best known host-microbe system, as well as findings from studies of microbial communities associated with other mammals, fish, plants, soil, and insects. The perspective adopted by this workshop is one that recognizes the breadth and diversity of host-microbe relationships beyond those relative few that result in overt disease. Included in this summary are the reports and papers of individuals participating in the Forum as well as the views of the editors.

Bioactive Components Of Human Milk

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Author : David S. Newburg
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Bioactive Components Of Human Milk written by David S. Newburg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

The major emphasis in this book is a compilation and definition of what is known about components of human milk, including glycoconjugates, that inhibit common pathogens of the infant. Also discussed are other bioactive constituents whose relevant biological roles are also beginning to be defined. Hormonal and cytokine activity, immunomodulating and autoinflammatory agents, xenobiotics, and conditionally essential nutrients in milk could have roles in the protection of the infant, but may also participate in digestive processes, maternal-infant communication, maturation of the gut, central nervous system, and other components of infant growth and development. Like the protective activities, these are discussed in terms of their presence in milk, structures, potential functions, and structure/function relationship. Components whose role is nutritional support during early development of the infant are also included.

Pneumonia Before Antibiotics

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Author : Scott H. Podolsky
language : en
Publisher: JHU Press
Release Date : 2006-05-01

Pneumonia Before Antibiotics written by Scott H. Podolsky and has been published by JHU Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-01 with Medical categories.

“Uses [pneumonia] as a vehicle for examining the evolution of therapeutics in America between the ‘Golden Age of Microbiology’ and the ‘Age of Antibiotics.’”—Isis Focusing largely on the treatment of pneumonia in first half of the century with type-specific serotherapy, clinician-historian Scott H. Podolsky provides insight into the rise and clinical evaluation of therapeutic “specifics,” the contested domains of private practice and public health, and—as the treatment of pneumonia made the transition from serotherapy to chemotherapy and antibiotics—the tempo and mode of therapeutic change itself. Type-specific serotherapy, founded on the tenets of applied immunology, justified by controlled clinical trials, and grounded in a novel public ethos, was deemed revolutionary when it emerged to replace supportive therapeutics. With the advent of the even more revolutionary sulfa drugs and antibiotics, pneumonia ceased to be a public health concern and became instead an illness treated in individual patients by individual physicians. Podolsky describes the new therapeutics and the scientists and practitioners who developed and debated them. He finds that, rather than representing a barren era in anticipation of some unknown transformation to come, the first decades of the twentieth-century shaped the use of, and reliance upon, the therapeutic specific throughout the century and beyond. This intriguing study will interest historians of medicine and science, policymakers, and clinicians alike. “Podolsky’s scholarship is awesome, and his grasp of the philosophical and sociologic context of the issues considered make this an important work.” —New England Journal of Medicine “This thoroughly documented, carefully written book is a landmark analysis . . . It should be read by everyone who is involved in research and therapeutic development.” —JAMA

Next Generation Probiotics From Commensal Bacteria To Novel Drugs And Food Supplements

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Author : Philippe Langella
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-22

Next Generation Probiotics From Commensal Bacteria To Novel Drugs And Food Supplements written by Philippe Langella and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-22 with categories.

Integrative Medicine For Children

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Author : May Loo
language : en
Publisher: Elsevier Health Sciences
Release Date : 2009

Integrative Medicine For Children written by May Loo and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Health & Fitness categories.

"Many parents today are turning to or seeking information about Complementary and Alternative Medicine (CAM) for their children. Whether you initiate alternative therapies or simply need to respond when asked for information or advice, it's crucial to have the most recent, evidence-based information about alternative therapies and know how to safely and effectively integrate them with conventional treatment. This innovative and reliable reference is the ideal resource to have at hand." "This book includes a wide range of complementary and alternative therapies, focusing on those most often used with children: mind/body approaches, manual therapies, lifestyle approaches, alternative systems, energy medicine, and biological agents. Within these main categories, therapies such as acupuncture, chiropractic, massage, homeopathy, herbs, and magnets are covered." "Fifty-five common pediatric conditions are comprehensively discussed, with diagnostic and evidence-based treatment information, followed by authoritative information on the major CAM therapies available for treatment of the condition. Whenever possible, an integrative approach that combines conventional and alternative approaches is presented."--BOOK JACKET.

Probiotics In Food Safety And Human Health

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Author : Ipek Goktepe
language : en
Publisher: CRC Press
Release Date : 2005-10-10

Probiotics In Food Safety And Human Health written by Ipek Goktepe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-10-10 with Technology & Engineering categories.

The discovery of new and previously unknown organisms that cause foodborne illness makes it essential for scientists, regulators, and those in the food industry to reconsider their traditional approaches to food preservation. A single source reference that can provide the latest practical information on how to deal with the range of probiotic healt