Birth Defects Research Part B Developmental And Reproductive Toxicology
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Birth Defects Research Part B Developmental And Reproductive Toxicology
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Author :
language : en
Publisher:
Release Date : 2003
Birth Defects Research Part B Developmental And Reproductive Toxicology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Birth Defects Research
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Author :
language : en
Publisher:
Release Date : 2006
Birth Defects Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Abnormalities, Human categories.
Issues In Birth Defects And Congenital And Genetic Diseases And Disorders 2011 Edition
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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-01-09
Issues In Birth Defects And Congenital And Genetic Diseases And Disorders 2011 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Birth Defects and Congenital and Genetic Diseases and Disorders. The editors have built Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Birth Defects and Congenital and Genetic Diseases and Disorders in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Birth Defects and Congenital and Genetic Diseases and Disorders: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
A Comprehensive Guide To Toxicology In Nonclinical Drug Development
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Author : Ali S. Faqi
language : en
Publisher: Elsevier
Release Date : 2024-02-11
A Comprehensive Guide To Toxicology In Nonclinical Drug Development written by Ali S. Faqi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-11 with Medical categories.
A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy Includes the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology
A Comprehensive Guide To Toxicology In Preclinical Drug Development
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Author : Ali S. Faqi
language : en
Publisher: Academic Press
Release Date : 2012-11-02
A Comprehensive Guide To Toxicology In Preclinical Drug Development written by Ali S. Faqi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-02 with Business & Economics categories.
A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --
Male Mediated Developmental Toxicity
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Author : Andrew F. Olshan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Male Mediated Developmental Toxicity written by Andrew F. Olshan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.
Developmental And Reproductive Toxicology
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Author : Ronald D Hood
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Developmental And Reproductive Toxicology written by Ronald D Hood and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers e
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Author :
language : en
Publisher: Waxmann Verlag
Release Date :
written by and has been published by Waxmann Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Scientific Frontiers In Developmental Toxicology And Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2000-12-21
Scientific Frontiers In Developmental Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-12-21 with Nature categories.
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2017-12-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-01 with Science categories.
Comprehensive Toxicology, Third Edition, Fifteen Volume Set discusses chemical effects on biological systems, with a focus on understanding the mechanisms by which chemicals induce adverse health effects. Organized by organ system, this comprehensive reference work addresses the toxicological effects of chemicals on the immune system, the hematopoietic system, cardiovascular system, respiratory system, hepatic toxicology, renal toxicology, gastrointestinal toxicology, reproductive and endocrine toxicology, neuro and behavioral toxicology, developmental toxicology and carcinogenesis, also including critical sections that cover the general principles of toxicology, cellular and molecular toxicology, biotransformation and toxicology testing and evaluation. Each section is examined in state-of-the-art chapters written by domain experts, providing key information to support the investigations of researchers across the medical, veterinary, food, environment and chemical research industries, and national and international regulatory agencies. Thoroughly revised and expanded to 15 volumes that include the latest advances in research, and uniquely organized by organ system for ease of reference and diagnosis, this new edition is an essential reference for researchers of toxicology. Organized to cover both the fundamental principles of toxicology and unique aspects of major organ systems Thoroughly revised to include the latest advances in the toxicological effects of chemicals on the immune system Features additional coverage throughout and a new volume on toxicology of the hematopoietic system Presents in-depth, comprehensive coverage from an international author base of domain experts