Male Mediated Developmental Toxicity
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Male Mediated Developmental Toxicity
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Author : Andrew F. Olshan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Male Mediated Developmental Toxicity written by Andrew F. Olshan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.
Advances In Male Mediated Developmental Toxicity
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Author : Bernard Robaire
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Advances In Male Mediated Developmental Toxicity written by Bernard Robaire and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume highlights major contributions that identify new developments and directions in the field over the past decade, as well as challenges for the foreseeable future. An integration of information from laboratory and epidemiological studies, male reproduction and teratology can be found throughout the volume. The range of topics include parental legacies and genomics, lifestyle, occupational and therapeutic paternal exposures and effects; effects on the gamete-packaging of human sperm; role of DNA repair and germ cell apoptosis; stem cells, epigenetics and closing; model systems and implications to clinicians and general counselors.
An Investigation Of The Herbicide Formulation Tordon 75d And Male Mediated Developmental Toxicity
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Author : Diana Joy Oakes
language : en
Publisher:
Release Date : 2000
An Investigation Of The Herbicide Formulation Tordon 75d And Male Mediated Developmental Toxicity written by Diana Joy Oakes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Herbicides categories.
Male Mediated Developmental Toxicity
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Author : Diana Anderson
language : en
Publisher: Royal Society of Chemistry
Release Date : 2007
Male Mediated Developmental Toxicity written by Diana Anderson and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Male germ line mutagenesis and the effects on developmental defects in the next generation.
Reproductive And Developmental Toxicology
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Author : Kenneth S . Korach
language : en
Publisher: CRC Press
Release Date : 1998-03-27
Reproductive And Developmental Toxicology written by Kenneth S . Korach and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-03-27 with Medical categories.
This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti
Scientific Frontiers In Developmental Toxicology And Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2000-12-21
Scientific Frontiers In Developmental Toxicology And Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-12-21 with Nature categories.
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Biologic Markers In Reproductive Toxicology
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1989-02-01
Biologic Markers In Reproductive Toxicology written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-02-01 with Social Science categories.
Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markersâ€"indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive abilityâ€"are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.
Exposing Men
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Author : Cynthia R. Daniels
language : en
Publisher: OUP USA
Release Date : 2006-08-31
Exposing Men written by Cynthia R. Daniels and has been published by OUP USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-31 with Political Science categories.
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Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-08-14
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-14 with Science categories.
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Exposing Men
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Author : Cynthia R. Daniels
language : en
Publisher: Oxford University Press
Release Date : 2006-08-31
Exposing Men written by Cynthia R. Daniels and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-31 with Political Science categories.
Exposing Men examines how ideals of masculinity have long skewed our societal--and scientific--understanding of one of the pillars of male identity: reproductive health. Only with the recent public exposure of men's reproductive troubles has the health of the male body been thrown into question, and along with it deeper masculine ideals. Whereas once men's sexual and reproductive abilities were the most taboo of topics, today erectile dysfunction is a multi-billion dollar business, and magazine articles trumpet male reproductive decline with headlines such as "You're Half the Man Your Father Was." Cynthia R. Daniels casts a gimlet eye on our world of plummeting sperm counts, spiking reproductive cancers, sperm banks, and pharmacological cures for impotence in order to assess the true state of male health. What she finds is male reproductive systems damaged by toxins and war, and proof piling up that men through sperm, pass on harm to the children they father. Yet, despite the evidence that men's health, as much as women's, significantly affects the vitality of their offspring, Daniels also sees a society holding on to outdated assumptions, one in which men ignore blatant health risks as they struggle to live up to antiquated ideas of manliness.