Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals
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Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-07-14
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Science categories.
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2017-08-14
Application Of Systematic Review Methods In An Overall Strategy For Evaluating Low Dose Toxicity From Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-14 with Science categories.
To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Review Of The Environmental Protection Agency S State Of The Science Evaluation Of Nonmonotonic Dose Response Relationships As They Apply To Endocrine Disruptors
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2014-05-27
Review Of The Environmental Protection Agency S State Of The Science Evaluation Of Nonmonotonic Dose Response Relationships As They Apply To Endocrine Disruptors written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-27 with Nature categories.
Potential health effects from chemicals that disrupt endocrine function pose an environmental health concern because of their ability to interfere with normal hormone function in human and wildlife populations. The endocrine system regulates biological processes throughout the body and is sensitive to small changes in hormone concentrations. Endocrine-disruptor research has focused primarily on chemicals that affect three hormone pathways that play important roles in reproduction and development - the estrogen, androgen, and thyroid hormone pathways. Some of this research has identified dose-response relationships that have nonmonotonic curves. Nonmonotonic dose-response curves (NMDRs) are of concern because they do not follow the usual assumption made in toxicology that as dose decreases the response also decreases. The existence of NMDRs has been a controversial topic for decades, and there has been considerable debate about their implications for how chemicals are tested and for how risks from such chemicals are assessed. Toxicity tests are designed to identify hazards and to characterize dose-response relationships, so tests are aimed at finding a (high) dose that elicits a response, and dose-response is explored by testing lower doses spaced to identify statistically a no- or lowest-observed-adverse-effect level. The concern for NMDRs is that such studies, as currently designed, might not detect the inflection of the dose-response curve if only a few doses are tested or if the change in inflection occurs below the range of doses tested. Another concern is that some NMDRs are found for biological effects that are not usually evaluated in toxicity tests. If current testing strategies are inadequate to account for NMDRs, changes to risk assessment practices might be necessary. To help address these issues, the U.S. Environmental Protection Agency (EPA) developed a draft State-of-the-Science Evaluation: Nonmonotonic Dose Responses as they Apply to Estrogen, Androgen, and Thyroid Pathways and EPA Testing and Assessment Procedures. EPA asked the National Research Council to conduct an independent review of this evaluation to ensure that it is scientifically sound and of high quality. Review of Environmental Protection Agency's State-of-the-Science Evaluation of Nonmonotonic Dose-Response as they Apply to Endocrine Disrupters evaluates whether EPA's evaluation presents a scientifically sound and high-quality analysis of the literature on NMDRs. This report reviews how well the EPA evaluation described how the assessment was performed, whether consistent methods and criteria were applied in the analysis of different evidence streams, and whether appropriate methods were applied to evaluating the evidence. The report makes recommendations to improve EPA's process and strengthen the evaluation.
Information Resources In Toxicology Volume 1 Background Resources And Tools
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Author : Steve Gilbert
language : en
Publisher: Academic Press
Release Date : 2020-05-16
Information Resources In Toxicology Volume 1 Background Resources And Tools written by Steve Gilbert and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-16 with Medical categories.
This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals Explores recent internet trends, web-based databases, and software tools in a section on the online environment Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field
Risk Assessment For Environmental Health
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Author : Mark G. Robson
language : en
Publisher: CRC Press
Release Date : 2022-12-30
Risk Assessment For Environmental Health written by Mark G. Robson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-30 with Medical categories.
Understanding risk to humans is one of the most important problems in environmental public health. Risk assessment is constantly changing with the advent of new exposure assessment tools, more sophisticated models, and a better understanding of disease processes. Risk assessment is also gaining greater acceptance in the developing world where major environmental problems exist. Developed in partnership with the Association of Schools of Public Health, this comprehensive text offers a thorough survey of risk assessment, management, and communications as these practices apply to public health. Key Features: Provides a practical overview of environmental risk assessment and its application by discussing the process and providing case studies and examples Focuses on tools and approaches used for humans in an environment involving potential chemical hazards Fully updated, the first part introduces the underlying principles and techniques of the field, and the second examines case studies in terms of different risk assessment scenarios Risk assessment is a core requirement for the MPH degree in environmental health Useful “stories” suitable for case studies
The Oxford Handbook Of Evolutionary Psychology And Behavioral Endocrinology
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Author : Lisa L. M. Welling
language : en
Publisher: Oxford University Press
Release Date : 2019-03-19
The Oxford Handbook Of Evolutionary Psychology And Behavioral Endocrinology written by Lisa L. M. Welling and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-19 with Psychology categories.
The Oxford Handbook of Evolutionary Psychology and Behavioral Endocrinology offers a comprehensive and compelling review of research in behavioral endocrinology from an evolutionary perspective on human psychology. Chapters, written by renowned experts on human behavior, explore a number of subtopics within one of three themes (1) development and survival, (2) reproductive behavior, and (3) social and affective behavior. Such topics include hormonal influences on life history strategy, mate choice, aggression, human hierarchical structure, and mood disorders. This Handbook is situated at the intersection of evolutionary psychology and behavioral endocrinology. Its interdisciplinary approach makes it an important resource for a broad spectrum of researchers, graduate students, and advanced undergraduates who are interested in studying the motivations and mechanisms that affect behavior.
A Class Approach To Hazard Assessment Of Organohalogen Flame Retardants
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-08-19
A Class Approach To Hazard Assessment Of Organohalogen Flame Retardants written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-19 with Political Science categories.
In the 1970s, flame retardants began to be added to synthetic materials to meet strict flammability standards. Over the years, diverse flame retardants have been manufactured and used in various products. Some flame retardants have migrated out of the products, and this has led to widespread human exposure and environmental contamination. There also is mounting evidence that many flame retardants are associated with adverse human health effects. As a result, some flame retardants have been banned, restricted, or voluntarily phased out of production and use. This publication develops a scientifically based scoping plan to assess additive, nonpolymeric organohalogen flame retardants as a class for potential chronic health hazards under the Federal Hazardous Substances Act, including cancer, birth defects, and gene mutations.
Toxicological Risk Assessment And Multi System Health Impacts From Exposure
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Author : Aristidis M. Tsatsakis
language : en
Publisher: Elsevier
Release Date : 2021-08-01
Toxicological Risk Assessment And Multi System Health Impacts From Exposure written by Aristidis M. Tsatsakis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-01 with Medical categories.
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Phthalates And Cumulative Risk Assessment
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2009-01-19
Phthalates And Cumulative Risk Assessment written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-01-19 with Nature categories.
People are exposed to a variety of chemicals throughout their daily lives. To protect public health, regulators use risk assessments to examine the effects of chemical exposures. This book provides guidance for assessing the risk of phthalates, chemicals found in many consumer products that have been shown to affect the development of the male reproductive system of laboratory animals. Because people are exposed to multiple phthalates and other chemicals that affect male reproductive development, a cumulative risk assessment should be conducted that evaluates the combined effects of exposure to all these chemicals. The book suggests an approach for cumulative risk assessment that can serve as a model for evaluating the health risks of other types of chemicals.
Casarett Doull S Essentials Of Toxicology Fourth Edition
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Author : Curtis D. Klaassen
language : en
Publisher: McGraw Hill Professional
Release Date : 2021-06-29
Casarett Doull S Essentials Of Toxicology Fourth Edition written by Curtis D. Klaassen and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-29 with Medical categories.
Develop a strong foundation in the concepts and principles of toxicology with this concise and accessible resource Doody's Core Titles for 2023! For more than 25 years, Casarett & Doull’s Toxicology: The Basics of Poison has set the standard for providing thorough, academic, and authoritative information in clear and engaging ways. Distilling the major principles and concepts from that renowned text, Casarett & Doull’s Essentials of Toxicology delivers an accessible and highly readable introduction to the science and clinical field of medical toxicology. The book reflects the expertise of more than 60 renowned contributors. Presented in full-color, this new edition builds on the wide success of previous editions, with extensive updates that make the book more clinically relevant to students and beginners in toxicology, pharmacology, pharmacy, and environmental sciences. Chapter-ending self-assessment Q&As and other features make the learning process more effective and efficient. Casarett and Doull’s Essentials of Toxicology is organized into seven units: General Principles of Toxicology Disposition of Toxicants Non-organ-directed Toxicity Target Organ Toxicity Toxic Agents Environmental Toxicology Applications of Toxicology Succinct, yet comprehensive, the text covers essential principles, toxicokinetics, how toxic effects are passed on to succeeding generations, how each body system responds to poisons, and the specific effects of a wide range of toxic agents—from pesticides to radiation.