Information Resources In Toxicology Volume 1 Background Resources And Tools

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Information Resources In Toxicology Volume 1 Background Resources And Tools

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Author :
language : en
Publisher: Academic Press
Release Date : 2020-05-16

Information Resources In Toxicology Volume 1 Background Resources And Tools written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-16 with Technology & Engineering categories.

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources - Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles - Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals - Explores recent internet trends, web-based databases, and software tools in a section on the online environment - Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents - Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field

Information Resources In Toxicology Volume 2 The Global Arena

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Author :
language : en
Publisher: Academic Press
Release Date : 2020-05-15

Information Resources In Toxicology Volume 2 The Global Arena written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-15 with Medical categories.

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology's subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools.Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology's presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field.The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children's environmental health. - Opens with an overview of the international toxicology scene, organizations and activities involved with both the science and regulatory framework, and a specific look at the European Union's efforts - Offers an extensive collection of chapters covering over 40 countries and their toxicological infrastructure which includes listings of major books and journals, organizations, professional societies, universities, poison control centers, legislation, and online databases - Provides the Second Edition of the International Union of Pure and Applied Chemistry's Glossary of Terms Used in Toxicology, a carefully constructed and peer reviewed collation of critical terms in the science - Concludes with a potpourri of quotes concerning toxicology and their use in the arts and popular culture - Paired with Volume One, which offers chapters on a host of toxicology sub-disciplines, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over120 chapters contributions by experts and leaders in the field

Environmental And Biochemical Toxicology

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Author : Jürgen Gailer
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2022-06-21

Environmental And Biochemical Toxicology written by Jürgen Gailer and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-21 with Science categories.

This text coherently links biochemical fundamentals and mechanisms with economic and societal problems of environmental pollution. It addresses interdisciplinary topics such as regulatory problems, sampling and pollutant quantifi cation, model organisms and provides a philosophical perspective on the toxin load on a variety of organisms, including humans in the environment in the Anthropocene. Case studies and exercises illustrate current issues and discuss future aspects.

Drug Discovery And Evaluation Safety And Pharmacokinetic Assays

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Author : Franz J. Hock
language : en
Publisher: Springer Nature
Release Date : 2024-10-21

Drug Discovery And Evaluation Safety And Pharmacokinetic Assays written by Franz J. Hock and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-21 with Medical categories.

Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process starting with the selection of the most pharmacologically active compound from a series of newly synthesized small molecule chemical series by means of distinctive pharmacological assays. Safety aspects were addressed by evaluation of the selected compound at high doses in a series of specific studies directed at indications other than the intended indication of the new compound. These tests are then followed by pharmacokinetic studies, which are primarily conducted to confirm whether the selected compound possesses a suitable half-life for sufficient exposure and efficacy and, whether it has the desired properties specificity to the intended route of administration. Safety aspects relied predominantly on the conduct of single and repeat toxicologydose studies, which inform changes in organ structure rather than organ function. Both toxicological and pharmacokinetic studies are adapted to the progress of studies in clinical pharmacology and clinical trials. The new edition of this well and broadly accepted reference work contains several innovative and distinguished chapters. This "sequential" strategy has been abandoned with this new version of the book for several reasons: - Of the possible multitude of negative effects that novel drugs may impart on organ function, e.g. ventricular tachy-arrhythmia, many are detected too late in non-clinical studies to inform clinicians. On the other hand, negative findings in chronic toxicity studies in animals may turn out to be irrelevant for human beings. - New scientific approaches, e.g. high-throughput screening, human pluripotent stem cells, transgenic animals, knock-out animals, in silico models, pharmaco-genomics and pharmaco-proteomics, as well as Artificial Intelligence (AI) methods offered new possibilities. - There are several examples, that show that the "druggability" of compounds was considerably underestimated when the probability of success of a new project was assessed. The success rate in the pharmaceutical industry and the introduction of new chemical entities to the market per year dropped dramatically, whereas the development time for a new compound increased, sometimes exceeding the patent protection. Research and development scientists, involving the following changes, therefore adopted a change of strategy: - Parallel instead of sequential involvement of the various disciplines (multidimensional compound optimization). - The term "Safety Pharmacology" was coined. The International Conference on Harmonization (ICH) founded a Safety Pharmacology Working Group and the Safety Pharmacology Society (SPS) was launched. The discipline provided for evaluation, development and validation of a multitude of safety tests outlined in the 'Core Battery of Studies'. - Characterizing the exposure profile of a drug by conducting pharmacokinetic studies that evaluates the absorption, distribution, metabolism and excretion should to be investigated at an early stage of development as results contribute to the selection of a compound for further development. Advancements in Toxicology were achieved by the introduction of new methods, e.g., in silico methods, genetic toxicology, computational toxicology and AI. The book is a landmark in the continuously changing world of drug research and developments. As such, it is essential reading for many groups: not only for all students of pharmacology and toxicology but also for industry scientists and physicians, especially those involved in clinical trials of drugs, and for pharmacists who must know the safety requirements of drugs. The book is essential for scientists and managers in the pharmaceutical industry who are involved in drug discovery, drug development and decision making in the development process. In particular, the book will be of use to government institutions and committees working on official guidelines for drug evaluation worldwide.

Unraveling Environmental Disasters

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Author : Daniel A. Vallero
language : en
Publisher: Elsevier
Release Date : 2023-10-17

Unraveling Environmental Disasters written by Daniel A. Vallero and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-17 with Nature categories.

Unraveling Environmental Disasters, Second Edition provides scientific explanations of the most threatening current and future environmental disasters, including an analysis of ways disasters could have been prevented and how to minimize risk of similar disasters in the future. In this new edition the authors provide foundational knowledge on why certain environmental disasters occur and ways of reducing the risk of recurrences. Anyone involved in teaching or working in the main sciences of physics, chemistry, and biology, or in the applied sciences, including engineering, design, planning, and homeland security, should read the book to become acquainted with these very important issues. - Evaluates natural hazards and disasters with an emphasis on lessons learned for better future forecasting - Considers the impact of human systems on environmental disasters, treating disasters as complex systems - Provides detailed predictions, based upon sound science, on why disasters occur - Includes fully updated chapters on food, health, and water - Focuses on both theoretical and practical aspects of each disaster - Includes disasters related to climate change and pollution

Advanced Introduction To Bounded Rationality

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Author : Clement A. Tisdell
language : en
Publisher: Edward Elgar Publishing
Release Date : 2023-01-13

Advanced Introduction To Bounded Rationality written by Clement A. Tisdell and has been published by Edward Elgar Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-13 with Business & Economics categories.

Offering a concise and engaging overview of the concepts of bounded rationality and their applications, this stimulating Advanced Introduction engages with the topic in a constructively critical manner, introducing new ideas. Chapters cover key topics including: optimally imperfect decisions; ecological rationality; the role of bounded rationality in evolutionary economics; satisficing as a response to bounded rationality; desirable types of economic decisions; the relational exercise of foresight; and the impact of bounded rationality of the efficiency of organizations.

Toxicology And Environmental Health Information Resources

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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 1997-02-10

Toxicology And Environmental Health Information Resources written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-02-10 with Science categories.

The environment is increasingly recognized as having a powerful effect on human and ecological health, as well as on specific types of human morbidity, mortality, and disability. While the public relies heavily on federal and state regulatory agencies for protection from exposures to hazardous substances, it often looks to health professionals for information about routes of exposure and the nature and extent of associated adverse health consequences. However, most health professionals acquire only a minimal knowledge of toxicology during their education and training. In 1967 the National Library of Medicine (NLM) created an information resource, known today as the Toxicology and Environmental Health Information Program (TEHIP). In 1995 the NLM asked the Institute of Medicine to examine the accessiblity and utility of the TEHIP databases for the work of health professionals. This resulting volume contains chapters on TEHIP and other toxicology and environmental health databases, on understanding the toxicology and environmental health information needs of health professionals, on increasing awareness of information resources through training and outreach, on accessing and navigating the TEHIP databases, and on program issues and future directions.

Selected Water Resources Abstracts

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Author :
language : en
Publisher:
Release Date : 1987-12

Selected Water Resources Abstracts written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-12 with Water categories.

Epa Publications Bibliography

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Author : United States. Environmental Protection Agency
language : en
Publisher:
Release Date : 1991

Epa Publications Bibliography written by United States. Environmental Protection Agency and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Environmental protection categories.

Epa Publications Bibliography Quarterly Abstract Bulletin

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Author : United States. Environmental Protection Agency
language : en
Publisher:
Release Date : 1997-10

Epa Publications Bibliography Quarterly Abstract Bulletin written by United States. Environmental Protection Agency and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-10 with Environmental protection categories.