Bispecific Antibodies
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Bispecific Antibodies
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Author : Roland E. Kontermann
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-07-21
Bispecific Antibodies written by Roland E. Kontermann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-21 with Medical categories.
The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed several years ago. Initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. The progress in antibody engineering finally led to the generation of new classes of bispecific antibodies lacking these obstacles. In addition, new applications were established, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different ways of generating bispecific antibodies are described, with emphasis on recombinant formats. The various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies are covered, and emerging applications such as dual targeting strategies, which involve the simultaneous inhibition of two targets, are addressed.
Bispecific Antibodies For T Cell Based Immunotherapy
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Author : Brian H. Santich
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-21
Bispecific Antibodies For T Cell Based Immunotherapy written by Brian H. Santich and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-21 with Medical categories.
CK is affiliated with the Roche Innovation Center Zurich, holds stocks and has patents with Hoffmann-La Roche company. NKC reports receiving commercial research grants from Y-mabs Therapeutics and Abpro-Labs Inc.; holding ownership interest/equity/options in Y-Mabs Therapeutics Inc., and in Abpro-Labs, and owning stock options in Eureka Therapeutics. NKC is the inventor of pending and issued patents filed by MSK, including hu3F8 and 8H9 licensed to Ymabs Therapeutics, beta-glucan to Biotec Pharmacon, and HER2 bispecific antibody to Abpro-labs. NKC is an advisory board member for Abpro-Labs and Eureka Therapeutics
Bispecific Antibodies
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Author : Roland E. Kontermann
language : en
Publisher:
Release Date : 2011-08-31
Bispecific Antibodies written by Roland E. Kontermann and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-31 with categories.
Bispecific Antibodies
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Author : Michael W. Fanger
language : en
Publisher: Springer
Release Date : 1995-01-01
Bispecific Antibodies written by Michael W. Fanger and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-01 with Antibody-drug conjugates categories.
Murine, human, and chimeric monoclonal antibodies (mAB) are currently being used for the treatment of a variety of human disorders including cancer. Bispecific antibodies (BsAB) have been developed as reagents that may permit even more specific linkages and mediate more efficient and appropriate bridges than mAB. The volume contains eight chapters: the production of BsAB; T cell-targeted cytotoxicity; myeloid cell-targeted cytotoxicity of tumor cells; natural killer cell-directed BsAB; targeted cytotoxicity of infectious agents and infectious cells; targeting drugs, toxins, and radionuclides with BsAB; targeting immune complexes and enzymes to cell surface receptors; and antigen targeting. Annotation copyright by Book News, Inc., Portland, OR
Monoclonal Antibodies
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Author : Mary A. Ritter
language : en
Publisher: Cambridge University Press
Release Date : 1995-01-26
Monoclonal Antibodies written by Mary A. Ritter and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-26 with Medical categories.
This book aims to provide a unique combination of the production (by both cellular and molecular biology techniques), structure and functional characteristics of monoclonal antibodies, together with detailed discussions of the various analytic, diagnostic and therapeutic applications.
Cell Therapy Bispecific Antibodies And Other Immunotherapies Against Cancer
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Author : Vita Golubovskaya
language : en
Publisher: Mdpi AG
Release Date : 2023-11-29
Cell Therapy Bispecific Antibodies And Other Immunotherapies Against Cancer written by Vita Golubovskaya and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-29 with Medical categories.
This Special Issue in Cancers is focused on cell therapy, bispecific antibodies, and other immunotherapies against cancer. It includes reports on cell therapies such as CAR-NK cell therapies, and bispecific antibodies against multiple myeloma and B cell lymphoma. Immunotherapies against solid tumors include TGF-beta-PDL-1 fusion protein and EpCAM-CD3 bispecific antibody generated with mRNA-lipid nanoparticles (LNP) against colorectal tumors. The clinical studies ongoing with bi- and tri-specific T cell engager antibodies against solid tumors and advantages versus cell therapies are discussed. This Special Issue highlights novel approaches to cell therapies, bispecific antibodies, vaccines, and immunotherapies that will be interesting for cancer cell researchers, biologists, and oncologists.
Monoclonal Antibodies
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Author : Christian Klein
language : en
Publisher: MDPI
Release Date : 2018-04-27
Monoclonal Antibodies written by Christian Klein and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-27 with Electronic book categories.
This book is a printed edition of the Special Issue "Monoclonal Antibodies" that was published in Antibodies
Structure And Function Of Antibodies
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Author : Roy Jefferis
language : en
Publisher: MDPI
Release Date : 2021-02-05
Structure And Function Of Antibodies written by Roy Jefferis and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-05 with Science categories.
This book provides a detailed description of all kinds of therapeutic antibodies including IgGs, IgAs, IgEs, and IgMs, bispecific antibodies, chimeric antigen receptor antibodies, and antibody fragments. Details about how each of these antibodies interact with their ligands, the immune system, and their targets are provided. Additionally, this book delves into the details of antibody, Fc, and variable chain structures, and how subtle changes in structure, charge, flexibility, post-translational modification, and the ability to bind to natural antibody ligands can result in a significant impact on antibody activity and functionality. Finally, the book explains the critical quality attributes of modern therapeutic antibodies and how to ensure that antibodies entering development have the best possible chance of success.
Antibody Therapeutics
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Author : William J. Harris
language : en
Publisher: CRC Press
Release Date : 2019-10-10
Antibody Therapeutics written by William J. Harris and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-10 with Medical categories.
Published in 1997: Antibody Therapeutics is a comprehensive evaluation of progress toward using humanized antibodies as a new generation of therapeutics. The humanized antibodies that have led the way in product approval are discussed as case studies, offering an insight into the preclinical and clinical data acquired during the regulatory approval process. Leading experts offer their findings as examples of what works and what does not, saving you time and making your research more cost effective. This book is essential reading for researchers, clinicians, development and regulatory staff in pharmaceutical and biotechnology companies, and hospital staff, including policy and decision makers. It also provides postgraduate and medical students with an authoritative overview of the field.
New Chimeric Monoclonal Antibodies Against Human Carcinomas
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Author : Rosalie Margaretha Luiten
language : en
Publisher:
Release Date : 1998
New Chimeric Monoclonal Antibodies Against Human Carcinomas written by Rosalie Margaretha Luiten and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Cancer categories.