Bisphosphonates And Osteonecrosis Of The Jaw A Multidisciplinary Approach


Bisphosphonates And Osteonecrosis Of The Jaw A Multidisciplinary Approach
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Bisphosphonates And Osteonecrosis Of The Jaw A Multidisciplinary Approach


Bisphosphonates And Osteonecrosis Of The Jaw A Multidisciplinary Approach
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Author : Francesco Saverio De Ponte
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-11-25

Bisphosphonates And Osteonecrosis Of The Jaw A Multidisciplinary Approach written by Francesco Saverio De Ponte and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-25 with Medical categories.


During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.



Medication Related Osteonecrosis Of The Jaws


Medication Related Osteonecrosis Of The Jaws
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Author : Sven Otto
language : en
Publisher: Springer
Release Date : 2014-11-27

Medication Related Osteonecrosis Of The Jaws written by Sven Otto and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-27 with Medical categories.


Osteonecrosis of the jaws is a well-known side-effect of antiresorptive therapy that predominantly occurs in patients suffering from malignant diseases and receiving intravenous administrations of nitrogen-containing bisphosphonates or subcutaneous administrations of denosumab, a monoclonal antibody. Less frequently it may also be observed in patients with osteoporosis who are being treated with these antiresorptive drugs This textbook provides detailed, up-to-date information on all aspects of medication-related osteonecrosis of the jaws, including clinical features, pathogenesis, treatment options, and preventive measures. It also explains safe prevention and treatment strategies for patients receiving antiresorptive drugs who require extractions, implant insertions, and other dento-alveolar surgeries. This book will be of major interest for medical and dental students, dentists, and oral and maxillofacial surgeons as well as osteologists and oncologists.



Management Of Medication Related Osteonecrosis Of The Jaw An Issue Of Oral And Maxillofacial Clinics Of North America 27 4


Management Of Medication Related Osteonecrosis Of The Jaw An Issue Of Oral And Maxillofacial Clinics Of North America 27 4
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Author : Salvatore L. Ruggiero
language : en
Publisher: Elsevier Health Sciences
Release Date : 2016-01-07

Management Of Medication Related Osteonecrosis Of The Jaw An Issue Of Oral And Maxillofacial Clinics Of North America 27 4 written by Salvatore L. Ruggiero and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-07 with Medical categories.


Editor Salvatore Ruggiero, DMD, MD and authors review the Diagnosis, Management and Prevention of Medication-related Osteonecrosis of the Jaw. Articles will include: Osteoporosis and bone modulation therapies: indications and outcomes; Antiresorptive therapies for the treatment of malignant osteolytic bone disease; Clinical presentation and staging of antiresorptive agent-induced osteonecrosis of the jaw; Epidemiology and risk factors of antiresorptive agent-induced osteonecrosis of the jaw; Basic science research of antiresorptive agent-induced osteonecrosis of the jaw: an update; Pathophysiology of antiresorptive agent-induced osteonecrosis of the jaw: what we know and what we don’t know; The genetics of osteonecrosis of the jaw; Preventive strategies for patients at risk of antiresorptive agent-induced osteonecrosis of the jaw; Non-operative and operative therapies for treatment of antiresorptive agent-induced osteonecrosis of the jaw; The role of anti-angiogenic therapy in the development of osteonecrosis of the jaw; Antiresorptive therapies: what they are and how do they work, and more!



Oral Intravenous Bisphosphonate Induced Osteonecrosis Of The Jaws


Oral Intravenous Bisphosphonate Induced Osteonecrosis Of The Jaws
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Author : Robert E. Marx
language : en
Publisher: Quintessence Publishing (IL)
Release Date : 2006

Oral Intravenous Bisphosphonate Induced Osteonecrosis Of The Jaws written by Robert E. Marx and has been published by Quintessence Publishing (IL) this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.


Oral and Intravenous Bisphosphonate-Induced Osteonecrosis of the Jaws deals with dentistry.



Bisphosphonates And Osteonecrosis Of The Jaw Volume 1218


Bisphosphonates And Osteonecrosis Of The Jaw Volume 1218
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Author : John P. Bilezikian
language : en
Publisher: Wiley-Blackwell
Release Date : 2011-03-14

Bisphosphonates And Osteonecrosis Of The Jaw Volume 1218 written by John P. Bilezikian and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-14 with Medical categories.


"This volume presents manuscripts stemming from the conference entitled 'Bisphosphonates & Osteonecrosis of the Jaw,' held May 19, 2007 at the New York Academy of Sciences



Antiresorptive Drug Related Osteonecrosis Of The Jaw Aronj A Guide To Research


Antiresorptive Drug Related Osteonecrosis Of The Jaw Aronj A Guide To Research
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Author : Kenneth Fleisher
language : en
Publisher: Thieme
Release Date : 2021-05-19

Antiresorptive Drug Related Osteonecrosis Of The Jaw Aronj A Guide To Research written by Kenneth Fleisher and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-19 with Medical categories.


A collaboration between some of the leading international experts in the field, AOCMF proudly presents Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research, which unravels the many biologic processes and risk factors associated with this debilitating condition. With its unknown pathophysiology, lack of established management regimens, and because of the millions of patients currently taking antiresorptive agents, this important book on ARONJ has been produced to provide the latest in contemporary evidence and insight. The book's key features include: Detailed analysis of the historical definitions, classifications, and clinical features of ARONJ Review of the risk factors and treatment options currently available, and why the jaw bone is predominantly affected Discussion on the use of large and small animals in modelling. With dozens of clinical images to help illustrate the impact of this condition on real patients, Antiresorptive Drug-related Osteonecrosis of the Jaw (ARONJ)-a Guide to Research is an excellent resource for anyone involved or interested in this important medical field.



Multidisciplinary Approach To Osteoporosis


Multidisciplinary Approach To Osteoporosis
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Author : Andrea Lenzi
language : en
Publisher: Springer
Release Date : 2018-09-04

Multidisciplinary Approach To Osteoporosis written by Andrea Lenzi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-04 with Medical categories.


This book describes in detail the multidisciplinary management of osteoporosis, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical activity, nutritional strategies, and pharmacological treatment. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of osteoporosis, the incidence of which is increasing rapidly as populations age.



Oncologic Imaging A Multidisciplinary Approach


Oncologic Imaging A Multidisciplinary Approach
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Author : Paul M. Silverman
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-03-29

Oncologic Imaging A Multidisciplinary Approach written by Paul M. Silverman and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-29 with Medical categories.


Comprehensive, authoritative, and up to date, Oncologic Imaging: A Multidisciplinary Approach, 2nd Edition, covers every aspect of radiographic imaging for the diagnosis, treatment, and management of the cancer patient. Dr. Paul M. Silverman and an expert author team from MD Anderson Cancer Center provide all the current, practical information available, while incorporating their unique experience based upon extensive, daily clinical care of patients with cancer. In one convenient volume, this definitive, one-of-a-kind text discusses new diagnostic imaging and surgical approaches as well as therapeutic cutting-edge treatments from radiation and medical oncology, focusing on best practices and the newest standards for personalized medicine. Brings together a unique multidisciplinary team of authors including clinical radiologists, medical oncologists, radiation oncologists, and surgical oncologists who reflect team-based practice. Features an all-new chapter on head and neck imaging, authored by world experts in this complex area. Contains extensive updates throughout, including transformational state-of-the-art imaging modalities such as PET/CT, and the full range of traditional modalities, including multidetector CT (MDCT), ultrasound, and MR in conjunction with the latest advances in genetics, molecular oncology, and targeted therapies. Distills practical, up-to-date information into a concise and consistent format with key point summaries, algorithms, clear drawings, and full-color staging diagrams. Includes emerging options for care based on practice recommendations and evidence in the literature. Provides updated tumor staging information based on the AJCC Classification of Malignant Tumors, 8th edition. Highlights the text with 1,000 high-quality radiographic images: CT, MR, hybrid imaging (PET/CT, PET/MR), mammography, and ultrasound, as well as clear line anatomic drawings, graphs, and algorithms.



Drug Induced Oral Complications


Drug Induced Oral Complications
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Author : Sarah Cousty
language : en
Publisher: Springer Nature
Release Date : 2021-05-24

Drug Induced Oral Complications written by Sarah Cousty and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-24 with Medical categories.


This book provides detailed information on the prevalence and manifestations of the most important oral complications associated with different drug treatments, focusing especially on recently developed therapies. Among the diverse adverse drug reactions covered are gingival overgrowth, ulcerations, lichenoid reactions, pigmentation, and bullous reactions. The potential direct toxic effects on bone of drugs that prevent bone mass loss, such as bisphosphonates and denosumab, are fully examined, as is the occurrence of spontaneous oral bleeding in patients receiving antithrombotic therapies. Further chapters focus on drug-induced taste disorders and salivary gland disturbances, including xerostomia, swelling, and hypersalivation. The enhanced risk of oral infections when using chemotherapy and biotherapy is addressed, and the closing chapter examines drug-related perioral and facial complications. This book is a collaborative work that brings together clinicians, surgeons, and specialists in drug safety surveillance. It will be of value for all dental and medical practitioners who encounter these complications in their clinical practice.



Fragility Fracture Nursing


Fragility Fracture Nursing
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Author : Karen Hertz
language : en
Publisher: Springer
Release Date : 2018-06-15

Fragility Fracture Nursing written by Karen Hertz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-15 with Medical categories.


This open access book aims to provide a comprehensive but practical overview of the knowledge required for the assessment and management of the older adult with or at risk of fragility fracture. It considers this from the perspectives of all of the settings in which this group of patients receive nursing care. Globally, a fragility fracture is estimated to occur every 3 seconds. This amounts to 25 000 fractures per day or 9 million per year. The financial costs are reported to be: 32 billion EUR per year in Europe and 20 billon USD in the United States. As the population of China ages, the cost of hip fracture care there is likely to reach 1.25 billion USD by 2020 and 265 billion by 2050 (International Osteoporosis Foundation 2016). Consequently, the need for nursing for patients with fragility fracture across the world is immense. Fragility fracture is one of the foremost challenges for health care providers, and the impact of each one of those expected 9 million hip fractures is significant pain, disability, reduced quality of life, loss of independence and decreased life expectancy. There is a need for coordinated, multi-disciplinary models of care for secondary fracture prevention based on the increasing evidence that such models make a difference. There is also a need to promote and facilitate high quality, evidence-based effective care to those who suffer a fragility fracture with a focus on the best outcomes for recovery, rehabilitation and secondary prevention of further fracture. The care community has to understand better the experience of fragility fracture from the perspective of the patient so that direct improvements in care can be based on the perspectives of the users. This book supports these needs by providing a comprehensive approach to nursing practice in fragility fracture care.