Blood Brain Barrier In Drug Discovery
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Blood Brain Barrier In Drug Discovery
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Author : Li Di
language : en
Publisher: John Wiley & Sons
Release Date : 2015-02-02
Blood Brain Barrier In Drug Discovery written by Li Di and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-02 with Medical categories.
Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market
Blood Brain Barrier In Drug Discovery
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Author : Li Di
language : en
Publisher: John Wiley & Sons
Release Date : 2014-12-29
Blood Brain Barrier In Drug Discovery written by Li Di and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-29 with Medical categories.
Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant – and most challenging – areas of drugdiscovery. • Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects • Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies • Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes • Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market
Brain Drug Targeting
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Author : William M. Pardridge
language : en
Publisher: Cambridge University Press
Release Date : 2001-05-31
Brain Drug Targeting written by William M. Pardridge and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-31 with Medical categories.
This challenging 2001 book reviews modern neurotherapeutics from the point of view of drug targeting.
The Blood Brain Barrier And Drug Delivery Of The Cns
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Author : Michael William Blackburn Bradbury
language : en
Publisher:
Release Date : 2000
The Blood Brain Barrier And Drug Delivery Of The Cns written by Michael William Blackburn Bradbury and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with MEDICAL categories.
This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research.Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNSassesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more!Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.
Nanotechnology Methods For Neurological Diseases And Brain Tumors
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Author : Yasemin Gürsoy Özdemir
language : en
Publisher: Academic Press
Release Date : 2017-07-14
Nanotechnology Methods For Neurological Diseases And Brain Tumors written by Yasemin Gürsoy Özdemir and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Medical categories.
Nanotechnology Methods for Neurological Diseases and Brain Tumors: Drug Delivery across the Blood-Brain Barrier compiles the latest (and future potential) treatment strategies for brain tumors and neurological diseases, in particular Alzheimer’s, Parkinson’s and stroke, those that bypass the blood/brain barrier. The current understanding of brain drug delivery and access is discussed in Chapter One, with the next section focusing on the implementation of the nose-to-brain intranasal route in brain-targeted drug delivery. In addition, nanotechnology-based brain drug delivery is covered in Chapter Three. This avenue offers impressive improvement in the treatment of neurological diseases and brain tumors by using bio-engineered systems that interact with biological systems at a molecular level. In Chapter Four, emphasis is placed on the need for brain-targeted experimental models that mimic disease conditions. Final chapters discuss the very latest advances in targeted treatment strategies for neurological diseases and brain tumors. Comprehensive guide for up-to-date views on the latest advances in targeted treatment strategies for brain tumors and neurological diseases Designed with a multidisciplinary approach that links neurology, neuro-oncology and nanoscience to drug delivery to the brain with an emphasis on the blood-brain-barrier Written in a language that makes it easy to understand nanotechnology drug delivery techniques Presents a unique book that also covers advanced treatment approaches of neurological diseases and brain tumors
The Blood Brain Barrier And Drug Delivery To The Cns
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Author : Michael Bradbury
language : en
Publisher: CRC Press
Release Date : 2019-08-30
The Blood Brain Barrier And Drug Delivery To The Cns written by Michael Bradbury and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.
This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.
Drug Delivery To The Brain
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Author : Elizabeth C.M. de Lange
language : en
Publisher: Springer Nature
Release Date : 2022-05-24
Drug Delivery To The Brain written by Elizabeth C.M. de Lange and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-24 with Science categories.
The development of new CNS drugs is notoriously difficult. Drugs must reach CNS target sites for action and these sites are protected by a number of barriers, the most important being the blood–brain barrier (BBB). Many factors are therefore critical to consider for CNS drug delivery, e.g. active/passive transport across the BBB, intra-brain distribution, and central/systemic pharmacokinetics, to name a few. Neurological disease and trauma conditions add further complexity because CNS barriers, drug distribution and pharmacokinetics are dynamic and often changed by disease/trauma. Knowledge of all these factors and their interplay in different conditions is of utmost importance for proper CNS drug development and disease treatment. In recent years much information has become available for a better understanding of the many factors important for CNS drug delivery and how they interact to affect drug action. This book describes small and large drug delivery to the brain with an emphasis on the physiology of the BBB and the principles and concepts for drug delivery across the BBB and distribution within the brain. It contains methods descriptions for studying drug delivery, routes and approaches of administering drugs into the brain, the influence of disease, drug industry perspectives, and a primer on neuroanatomy and physiological considerations written specifically for drug delivery scientists. Therewith, it contributes to an in-depth understanding of the interplay between brain (patho)-physiology and drug characteristics. Furthermore, the content is designed to be both cutting-edge and educational, so that the book can be used in high-level training of academic and industry scientists with full references to original publications.
The Blood Brain Barrier Bbb
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Author : Gert Fricker
language : en
Publisher: Springer
Release Date : 2014-10-24
The Blood Brain Barrier Bbb written by Gert Fricker and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-24 with Science categories.
Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
The Blood Brain Barrier And Cns Drug Development
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Author :
language : en
Publisher:
Release Date : 2008
The Blood Brain Barrier And Cns Drug Development written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Bioavailability Of Drugs To The Brain And The Blood Brain Barrier
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Author : Jerry Frankenheim
language : en
Publisher: U.S. Government Printing Office
Release Date : 1992
Bioavailability Of Drugs To The Brain And The Blood Brain Barrier written by Jerry Frankenheim and has been published by U.S. Government Printing Office this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.