Blood Flow Dynamics In Burns
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Blood Flow Dynamics In Burns
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Author : Robin Mirdell
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-11-25
Blood Flow Dynamics In Burns written by Robin Mirdell and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-25 with categories.
Objectives: Burns of intermediate thickness are hard to evaluate clinically. This often leads to unnecessary delays of up to 14 days before a surgical decision can be made. To counter this, several objective methods have been developed to determine the healing potential of the wound. Over the years, measurement of perfusion has proven to be the most successful method for evaluation of healing potential. Laser Doppler imaging (LDI) is currently the most used method and can determine surgical need 2 days after injury with an accuracy >90%. There are however emerging techniques like laser speckle contrast imaging (LSCI), which also measure perfusion. LSCI have several advantages over LDI and is easier to use. LSCI can also investigate aspects of the microcirculation, previously not possible with LDI. The aim of this thesis was to investigate LSCI’s ability to evaluate surgical need in burns of indeterminate partial-thickness. The first objective was to investigate the dynamics of perfusion the first 14 days after injury. The purpose was to find the optimal time-window for perfusion measurements. The next goal was to determine the accuracy of different perfusion cut-offs. In this second study, the benefit of a subsequent measurement was also investigated. After this, interobserver variation between different profession groups was studied. Both the agreement of perfusion measurements and observer assessments were evaluated. Finally, cardiac vasomotion in combination with perfusion (pulsatility) was investigated as a method to determine surgical need <48 hours after injury. Methods: Perfusion was measured in a total of 77 patients at the Department of Plastic Surgery, Hand Surgery and Burns at Linköping University Hospital, Sweden. Most of these patients were children and the most common type of burn was scalds. A laser speckle contrast imager (PeriCam PSI System, Perimed AB, Järfälla, Sweden) was used to measure perfusion. Results: In the first paper we showed a clear relation between perfusion dynamics and the healing potential of the wound. The changes in perfusion were largest the first 5 days after injury, why this time interval was selected for subsequent papers. Perfusion measurements done day 3-4 after injury could predict surgical need with a sensitivity of 100% (95% CI: 83.9-100%) and a specificity of 90.4% (95% CI: 83.8-94.9%). If two measurements were used, <24 hours and 3-4 days after injury, the accuracy was 100%. Furthermore, we found that different observers could consistently predict perfusion, while there was a large variation in their clinical assessments. This was not improved by extensive burn experience. Finally, pulsatility could be used to predict surgical need the same day as the injury occurred with a sensitivity of 100% (95% CI: 88.1-100%) and a specificity of 98.8% (95% CI: 95.7- 99.9%). Conclusions: LSCI is a promising method for evaluation of burns and provides several benefits over LDI. The surgical need of burns can be determined mere hours after injury when pulsatility is measured. However, the benefits of early scald diagnostics in children with LSCI need to be evaluated in a prospective study before the method is ready for routine clinical use.
Research Grants Index
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Author : National Institutes of Health (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1970
Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Medicine categories.
Hot Topics In Burn Injuries
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Author : Selda Pelin Kartal
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-05-23
Hot Topics In Burn Injuries written by Selda Pelin Kartal and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-23 with Medical categories.
The aim of this book is to give readers a broad review of burn injuries, which may affect people from birth to death and can lead to high morbidity and mortality. The book consists of four sections and seven chapters. The first section consists of the introductory review chapter, which overviews the burn injuries. The second section includes chapter "Burn Etiology and Pathogenesis," which focuses on burn injuries and clinical findings. The third section consists of chapter "Controlling Inflammation in Burn Injury" and is devoted to the role of inflammatory response, which is fundamental to the healing process, while a prolonged inflammation may lead to scarring and fibrosis. The fourth section consists of four chapters as follows: "Therapeutic Effects of Conservative Treatments on Burn Scars," "Herbal Therapy for Burns and Burn Scars," "Platelet-Rich Plasma in Burn Treatment," and "Surgical Treatment of Burn Scars." The book is easy to read and includes hot topics on burn injury to enhance the reader's understanding and knowledge.
Chinese Burn Surgery
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Author : Zongcheng Yang
language : en
Publisher: Springer
Release Date : 2015-01-26
Chinese Burn Surgery written by Zongcheng Yang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-26 with Medical categories.
This is a comprehensive book in burn surgery, written by 25 experts in China. It summarizes the theoretical basis of and clinical experience in the prevention and control of burn injuries. It is a comprehensive and up-to-date reference book for surgeons and scientists working with burn management. The different degree of burns and surgical techniques during burn wound care, reconstruction and healing are reviewed separately. Authors also introduce successful cases in different kinds of burns.
Handbook Of Biophotonics
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Author : Jürgen Popp
language : en
Publisher: John Wiley & Sons
Release Date : 2011-11-30
Handbook Of Biophotonics written by Jürgen Popp and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-30 with Science categories.
This new handbook covers the world of biophotonics not only geographically -- with the editors coming from different continents -- but also in terms of content, since the authors come from the whole spectrum of biophotonic basic and applied research. Designed to set the standard for the scientific community, these three volumes break new ground by providing readers with the physics basics as well as the biological and medical background, together with detailed reports on recent technical advances. The Handbook also adopts an application-related approach, starting with the application and then citing the various tools to solve the scientific task, making it of particular value to medical doctors. Divided into several sections, the first part offers introductory chapters on the different fields of research, with subsequent parts focusing on the applications and techniques in various fields of industry and research. The result is a handy source for scientists seeking the basics in a condensed form, and equally a reference for quickly gathering the knowledge from neighboring disciplines. Absolutely invaluable for biophotonic scientists in their daily work.
High Resolution Imaging In Microscopy And Ophthalmology
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Author : Josef F. Bille
language : en
Publisher: Springer
Release Date : 2019-08-13
High Resolution Imaging In Microscopy And Ophthalmology written by Josef F. Bille and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-13 with Medical categories.
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Industrial Exposure And Control Technologies For Osha Regulated Hazardous Substances Substances K Z And Indices
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Author :
language : en
Publisher:
Release Date : 1989
Industrial Exposure And Control Technologies For Osha Regulated Hazardous Substances Substances K Z And Indices written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Hazardous substances categories.
Regulation Of Coronary Blood Flow
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Author : Michitoshi Inoue
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-09
Regulation Of Coronary Blood Flow written by Michitoshi Inoue and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-09 with Medical categories.
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences
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Author : National Institute of General Medical Sciences (U.S.)
language : en
Publisher:
Release Date : 1976
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences written by National Institute of General Medical Sciences (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medicine categories.
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences
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Author : National Institute of General Medical Sciences (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1976
Subject Index Of Current Research Grants And Contracts Administered By The National Institute Of General Medical Sciences written by National Institute of General Medical Sciences (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976 with Medicine categories.