Blood Substitutes And Oxygen Biotherapeutics

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Blood Substitutes And Oxygen Biotherapeutics

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Author : Henry Liu
language : en
Publisher: Springer Nature
Release Date : 2022-08-08

Blood Substitutes And Oxygen Biotherapeutics written by Henry Liu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-08 with Medical categories.

This book functions as a comprehensive and authoritative reference book in blood transfusion and blood substitutes. It is a collection of the latest developments and the newest investigations, and individual chapters are written by world experts in the arena. The book begins with a historical review on the practice of transfusions as well as the components and physiology of blood. The following chapters cover various topics, including platelet substitutes, hemoglobin-based oxygen carriers, perfluorocarbon based oxygen carriers, and safety issues related to artificial hemoglobin. All chapters provide a bulleted highlights list to facilitate readers in mastering the main points of each individual chapter. Blood Substitutes and Oxygen Biotherapeutics is an invaluable reference book for perioperative care providers, hematologists, anesthesiologists, surgeons, obstetricians and gynecologists.

Hemoglobin Based Oxygen Carriers As Red Cell Substitutes And Oxygen Therapeutics

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Author : Hae Won Kim
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-18

Hemoglobin Based Oxygen Carriers As Red Cell Substitutes And Oxygen Therapeutics written by Hae Won Kim and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-18 with Technology & Engineering categories.

Currently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.

Chemistry And Biochemistry Of Oxygen Therapeutics

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Author : Andrea Mozzarelli
language : en
Publisher: John Wiley & Sons
Release Date : 2011-07-07

Chemistry And Biochemistry Of Oxygen Therapeutics written by Andrea Mozzarelli and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-07 with Science categories.

Human blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen – the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or “blood substitutes”) which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury. The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in "non-surgical" patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in β thalassemia and sickle cell disease Finally “old”and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell storage; proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia – industry collaboration in blood substitute development. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.

Artificial Oxygen Carrier

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Author : K. Kobayashi
language : en
Publisher: Springer Science & Business Media
Release Date : 2005

Artificial Oxygen Carrier written by K. Kobayashi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.

While a reliable supply of donated blood is vital in modern medicine, it remains the case that blood transfusion comes with its own problems, such as infectious diseases, immunological adverse reactions, and difficulties with long-term storage and transportation of blood components. With a view to solving these problems, developing a suitable blood substitute has been a major goal for decades. Artificial Oxygen Carrier: Its Front Line is a compilation of reports on the concepts behind artificial oxygen carriers, as well as the new discoveries in the field that were presented during the 13th Keio International Symposium for Life Science and Medicine. This volume describes valuable topics, including artificial red blood cells, modified haemoglobin, perfluorocarbons, and haemoglobin vesicles. It explains cutting-edge developments in artificial oxygen carrier research and will be a valuable resource to all concerned with the field.

Blood Substitutes

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Author : Robert M. Winslow
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Blood Substitutes written by Robert M. Winslow and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

This volume contains a collection of essays by selected authors who are active in the field of blood substitutes research or closely allied disciplines. These essays were delivered as lectures by the authors at the second annual "Current Issues in Blood Substitute Research and Development - 1995" course sponsored jointly by the Departments of Medicine and Bioengineer ing, University of California, San Diego, the National Institutes of Health (NHLBI), and the U.S. Army on March 30, 31, and April 1, 1995 in San Diego. This course had three goals: to present fundaniental discussions of scientific issues critical to further development of artificial oxygen carriers, to provide academicians a forum to discuss their current research, and to provide the companies involved in developing products the opportunity to update the audience on their progress. The organization owes much to the solicited comments of the attendees of the 1994 course. We would like especially to thank the U.S. Army, particularly through the efforts of COL John Hess, who provided significant funding to make publication of this volume possible. In addition, a number of the participating companies provided additional financial support to offset the costs of the course. These include Alliance Pharmaceutical Corp., Hemosol, Nippon Oil and Fat, Northfield Laboratories, and Ortho Biotech.

Blood Substitutes

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Author : Robert M. Winslow
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Blood Substitutes written by Robert M. Winslow and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

This book is not a "proceedings" volume. Rather the chapters are essays by experts in the field of blood substitutes, invited by the editors to con tribute to the 1996 "Current Issues in Blood Substitutes Research and Development" course given in San Diego, March 18-21. The contributors were selected because of their expertise in areas deemed by the editors to be critical to the advancement of the field. The course, as in past years, is heavily influenced by feedback from par ticipants, and by research in this and related fields. In addition to the didactic lectures (for which these chapters are the foundation), the course also offers the opportunity for presentation of research reports, progress reports from the various companies currently commercializing products, and round table discussions of selected subjects. Thus, we are grateful to past participants for their helpful comments. Production of a book, especially on a short timeline, is not an easy feat.

Nanobiotherapeutic Based Blood Substitutes

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Author : Thomas Ming Swi Chang
language : en
Publisher: World Scientific
Release Date : 2021-10-28

Nanobiotherapeutic Based Blood Substitutes written by Thomas Ming Swi Chang and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-28 with Science categories.

This definitive volume will provide the reader with up to date information and the most recent science of the fast-evolving area of nanobiotherapeutic-based blood substitutes. Long studied, there are recent updates that make their use in patients more promising, and with one product approved for human use, many more in the pipeline. These include 2nd generations and even third generation ones, the later with enhancement of red blood cell functions. In addition, there are carefully written and referenced updates on the recent history and products in the field, complete with pathophysiologic and pharmacologic studies to validate and verify the efficacy and safety of many of these new products.

Blood Substitutes Hemoglobin Based Oxygen Carriers

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Author :
language : en
Publisher: Am Cncl on Science, Health
Release Date :

Blood Substitutes Hemoglobin Based Oxygen Carriers written by and has been published by Am Cncl on Science, Health this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Red Blood Cell Substitutes

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Author : Alan Rudolph
language : en
Publisher: CRC Press
Release Date : 1997-09-05

Red Blood Cell Substitutes written by Alan Rudolph and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-09-05 with Medical categories.

Presents an up-to-date treatment of research strategies, clinical and commercial developments, and regulatory and economic issues pertaining to the formulation of effective and safe red blood cell substitutes. The text examines regulatory and socioeconomic aspects of blood substitute products, and global tranfusion practices from the perspective of blood banks and the US Food and Drug Administrations. It also includes the mechanisms of action and consequences of blood substitute administration.

Oxygen Transport To Tissue Xxxvii

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Author : Clare E. Elwell
language : en
Publisher: Springer
Release Date : 2016-01-18

Oxygen Transport To Tissue Xxxvii written by Clare E. Elwell and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-18 with Medical categories.

This book contains the refereed contributions from the 42nd annual meeting of ISOTT. The annual meetings of ISOTT bring together scientists from various fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. ISOTT conferences are a place where an atmosphere of interaction is created, where many questions are asked after each presentation and lively discussions occur at a high scientific level. This vivid interaction is the main motivation for members to participate and gain new ideas and knowledge in the broad field of oxygen transport to tissue. The papers in this volume summarize some of the outstanding contributions from the 42nd annual meeting, which included sessions on: cellular hypoxia and mitochondria; blood substitutes and oxygen therapeutics; oxygen transport in critical care medicine and disease; muscle oxygenation; multi modal imaging techniques; brain oxygenation and imaging; optical techniques for oxygen measurement; microcirculation; mathematical modelling of oxygen transport; and cancer metabolism.