Bone Research Protocols
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Bone Research Protocols
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Author : Miep H. Helfrich
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Bone Research Protocols written by Miep H. Helfrich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
The last decade has seen a tremendous advance in our understanding of bone biology. The genes responsible for the majority of rare inherited bone disorders have been identified and much progress has been made in the identification of genes in polygenic disorders such as Paget’s disease and complex multigene diseases such as osteoporosis. Transgenic technology has identified further genes, sometimes unexpectedly, with profound effects on bone. This wealth of new genetic information will undoubtedly lead to extensive cell biological studies to understand the mechanisms by which these gene products affect bone mass and bone strength. In Bone Research Protocols a catalogue of protocols has been assembled to perform such mechanistic studies. In the tradition of the Methods in Molecular Medicine series, the chapters are practical laboratory protocols that should enable the reader to carry out the techniques from scratch. To our knowledge this is the first time such a truly practical manual on well-established bone methods has been assembled, and this volume aims to be complementary to and follow on from the more theoretical Methods in Bone Biology, edited by Arnett and Henderson (1).
Bone Research Protocols
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Author : Aymen I. Idris
language : en
Publisher: Springer Nature
Release Date : 2025-05-31
Bone Research Protocols written by Aymen I. Idris and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-31 with Science categories.
This third edition volume expands on the previous editions with new chapters and updated discussions on the latest advancements in the fields of musculoskeletal research and cancer-induced bone disease (CIBD). The chapters in this book are organized in to six parts and cover a wide range of established and new research procedures. Part One looks at methods for isolation, generation and analysis of osteoclasts, stem cells, circulating tumor cells, and bone marrow adipocytes. Part Two explores biochemical and molecular analysis procedures for isolation, purification, and quantification or mRNA and DNA in bone cells. Part Three focuses on ex vivo models of tissues, organs, and co-culture systems for bone and cancer cells, and Part Four presents various cancer related in vivo models of primary bone and secondary cancers in the skeleton. Part 5 discusses the frequently used bone microscopical and imaging analytical techniques, such as bone histomorphometry, immunostaining, and MicroCT scanning of bone. Finally Part Six talks about applications of GWAS, EWAS, systematic review, and meta-analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on trouble3.shooting and avoiding known pitfalls. Cutting-edge and comprehensive, Bone Research Protocols, Third Edition is a valuable resource for all researchers, scientists, and clinicians who are interested in learning more about this important and developing field.
Bone Substitute Biomaterials
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Author : K. Mallick
language : en
Publisher: Elsevier
Release Date : 2014-08-05
Bone Substitute Biomaterials written by K. Mallick and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-05 with Medical categories.
Bone substitute biomaterials are fundamental to the biomedical sector, and have recently benefitted from extensive research and technological advances aimed at minimizing failure rates and reducing the need for further surgery. This book reviews these developments, with a particular focus on the desirable properties for bone substitute materials and their potential to encourage bone repair and regeneration. Part I covers the principles of bone substitute biomaterials for medical applications. One chapter reviews the quantification of bone mechanics at the whole-bone, micro-scale, and non-scale levels, while others discuss biomineralization, osteoductivization, materials to fill bone defects, and bioresorbable materials. Part II focuses on biomaterials as scaffolds and implants, including multi-functional scaffolds, bioceramics, and titanium-based foams. Finally, Part III reviews further materials with the potential to encourage bone repair and regeneration, including cartilage grafts, chitosan, inorganic polymer composites, and marine organisms. - Provides a detailed and accurate overview of the bone substitute biomaterials, a fundamental part of the biomaterials and biomedical sector - Provides readers with the principles of bone substitute biomaterials - Reviews biomaterials for bone regeneration
Suicide Gene Therapy
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Author : Caroline J. Springer
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Suicide Gene Therapy written by Caroline J. Springer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Gene therapy has expanded rapidly over the last decade. The number of clinical trials reported by 2001 included 532 protocols and 3436 patients. Phase I trials predominate with 359 trials of 1774 patients versus Phase II (57 trials with 507 patients) and Phase III (3 trials of 251 patients). The disease overwhelmingly targeted by gene therapy is cancer: involving 331 trials with 2361 patients. Despite the somewhat disappointing results of clinical trials to date, gene therapy offers tremendous promise for the future of cancer therapy. The area of gene therapy is vast, and both malignant and nonmalignant cells can be targeted. Suicide Gene Therapy: Methods and Reviews covers gene therapy that targets malignant cells in a treatment that has become known as “suicide gene therapy. ” Basically, this approach uses the transduction of cancer cells with a gene for a foreign enzyme that, when expressed, is able to activate a nontoxic prodrug into a highly cytotoxic drug able to kill the cancer cell population. This is a major area in cancer gene therapy—in 2001 this technique was represented by 52 clinical protocols with a total of 567 patients. Additional trials used multiple gene therapy protocols that also involved suicide gene therapy (83 with 497 patients), indicating that the interest in this area is considerable. Suicide Gene Therapy: Methods and Reviews aims to cover comprehensively, both in theoretical and practical terms, the rapidly evolving area of suicide gene therapy for cancer.
Cartilage And Osteoarthritis
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Author : Massimo Sabatini
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Cartilage And Osteoarthritis written by Massimo Sabatini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to steadily increasing life expectancy and the demand for better quality of life. Because of its chronic nature and nonfatal outcome, OA affects the growing population of the elderly over an increasing time span. Moreover, despite its relatively benign character, OA is one of the most disabling diseases; it is responsible for increasing financial and social burdens in terms of medical treatments, forced inactivity, loss of mobility, and dependence. Despite a growing awareness of OA as a medical problem that has yet to reach its maximum impact on society, there is a surprising absence of effective medical treatments beyond pain control and surgery. So far, only symptom-modifying drugs are available, while there remains a major demand for disease-modifying treatments of proven clinical efficacy. This demand will hopefully be met in the future by some of the drugs that have been pressed into development and are now at different stages of clinical investigation. Nevertheless, the current lack of effective treatments reflects a still insufficient knowledge of cartilage with respect to its metabolism, interactions with other joint tissues, and causes and mechanisms (possibly of very different nature) leading to failure of its turnover.
Bone Toxicology
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Author : Susan Y. Smith
language : en
Publisher: Springer
Release Date : 2017-09-27
Bone Toxicology written by Susan Y. Smith and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-27 with Medical categories.
The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
Bone Research Protocols
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Author : Miep H. Helfrich
language : en
Publisher: Humana
Release Date : 2010-11-09
Bone Research Protocols written by Miep H. Helfrich and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-09 with Medical categories.
The last decade has seen a tremendous advance in our understanding of bone biology. The genes responsible for the majority of rare inherited bone disorders have been identified and much progress has been made in the identification of genes in polygenic disorders such as Paget’s disease and complex multigene diseases such as osteoporosis. Transgenic technology has identified further genes, sometimes unexpectedly, with profound effects on bone. This wealth of new genetic information will undoubtedly lead to extensive cell biological studies to understand the mechanisms by which these gene products affect bone mass and bone strength. In Bone Research Protocols a catalogue of protocols has been assembled to perform such mechanistic studies. In the tradition of the Methods in Molecular Medicine series, the chapters are practical laboratory protocols that should enable the reader to carry out the techniques from scratch. To our knowledge this is the first time such a truly practical manual on well-established bone methods has been assembled, and this volume aims to be complementary to and follow on from the more theoretical Methods in Bone Biology, edited by Arnett and Henderson (1).
Micro Computed Tomography Micro Ct In Medicine And Engineering
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Author : Kaan Orhan
language : en
Publisher: Springer
Release Date : 2019-07-25
Micro Computed Tomography Micro Ct In Medicine And Engineering written by Kaan Orhan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-25 with Medical categories.
This book focuses on applications of micro CT, CBCT and CT in medicine and engineering, comprehensively explaining the basic principles of these techniques in detail, and describing their increasing use in the imaging field. It particularly highlights the scanning procedure, which represents the most crucial step in micro CT, and discusses in detail the reconstruction process and the artifacts related to the scanning processes, as well as the imaging software used in analysis. Written by international experts, the book illustrates the application of micro CT in different areas, such as dentistry, medicine, tissue engineering, aerospace engineering, geology, material engineering, civil engineering and additive manufacturing. Covering different areas of application, the book is of interest not only to specialists in the respective fields, but also to broader audience of professionals working in the fields of imaging and analysis, as well as to students of the different disciplines.
Anticoagulants Antiplatelets And Thrombolytics
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Author : Shaker A. Mousa
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Anticoagulants Antiplatelets And Thrombolytics written by Shaker A. Mousa and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
This collection of review articles highlights the latest development of antithrombotics and provides proven experimental methods for the further development of new and improved anticoagulants. Among the cutting-edge developments reviewed are the novel usage of low molecular weight heparins, such antithrombin agents as the hirudin, and such antiplatelet drugs as the GPIIb/IIIa inhibitors and ADP receptor antagonists.
Mechanics Of Biological Systems And Materials Volume 2
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Author : Tom Proulx
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-05-20
Mechanics Of Biological Systems And Materials Volume 2 written by Tom Proulx and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-20 with Technology & Engineering categories.
Mechanics of Biological Systems and Materials represents one of eight volumes of technical papers presented at the Society for Experimental Mechanics Annual Conference & Exposition on Experimental and Applied Mechanics, held at Uncasville, Connecticut, June 13-16, 2011. The full set of proceedings also includes volumes on Dynamic Behavior of Materials, Mechanics of Time-Dependent Materials and Processes in Conventional and Multifunctional Materials, MEMS and Nanotechnology; Optical Measurements, Modeling and, Metrology; Experimental and Applied Mechanics, Thermomechanics and Infra-Red Imaging, and Engineering Applications of Residual Stress.