Brain Lipids In Synaptic Function And Neurological Disease

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Brain Lipids In Synaptic Function And Neurological Disease

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Author : Jacques Fantini
language : en
Publisher: Academic Press
Release Date : 2015-05-12

Brain Lipids In Synaptic Function And Neurological Disease written by Jacques Fantini and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-12 with Medical categories.

Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. - Written to provide a "hands-on" approach for readers - Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings - Step-by-step guide to memorize and draw lipid structures - Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique

Omega 3 Fatty Acids In Brain And Neurological Health

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Author : Ronald Ross Watson
language : en
Publisher: Elsevier
Release Date : 2014-06-25

Omega 3 Fatty Acids In Brain And Neurological Health written by Ronald Ross Watson and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-25 with Science categories.

Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep, and neurodegenerative diseases. This collection helps to push research forward toward a complete understanding of omega-3 fatty acids' relationship to brain and neurological health. - The first book-length collection of original research on the connection between omega-3 fatty acids and the brain - Provides a comprehensive introduction to the state of research on omega-3 fatty acids and the brain and directions for future research - A foundational collection for neuroscience, neurology, and nutrition research

Polyunsaturated Fatty Acid Metabolism

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Author : Graham C. Burdge
language : en
Publisher: Elsevier
Release Date : 2018-05-04

Polyunsaturated Fatty Acid Metabolism written by Graham C. Burdge and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with Science categories.

Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. - Provides a comprehensive view of polyunsaturated fatty acid metabolism - Describes underlying metabolism on lipids that include polyunsaturated fatty acids - Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism

The Role Of Glycosylation In Health And Disease

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Author : Gordan Lauc
language : en
Publisher: Springer Nature
Release Date : 2021-09-08

The Role Of Glycosylation In Health And Disease written by Gordan Lauc and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-08 with Science categories.

Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.

Basic Neurochemistry

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Author : R. Wayne Albers
language : en
Publisher: Academic Press
Release Date : 2011-11-02

Basic Neurochemistry written by R. Wayne Albers and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-11-02 with Science categories.

Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology. - Completely updated text with new authors and material, and many entirely new chapters - Over 400 fully revised figures in splendid color - 61 chapters covering the range of cellular, molecular and medical neuroscience - Translational science boxes emphasizing the connections between basic and clinical neuroscience - Companion website at http://elsevierdirect.com/companions/9780123749475

Lipid Signaling And Metabolism

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Author : James M. Ntambi
language : en
Publisher: Academic Press
Release Date : 2020-08-09

Lipid Signaling And Metabolism written by James M. Ntambi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-09 with Science categories.

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. - Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies - Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine - Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Research Grants Index

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Author : National Institutes of Health (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1967

Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1967 with Medicine categories.

Cumulated Index Medicus

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Author :
language : en
Publisher:
Release Date : 1973

Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Medicine categories.

Biochemical Factors Concerned In The Functional Activity Of The Nervous System

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Author : D. Richter
language : en
Publisher: Elsevier
Release Date : 2013-10-22

Biochemical Factors Concerned In The Functional Activity Of The Nervous System written by D. Richter and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.

Biochemical Factors Concerned in the Functional Activity of the Nervous System presents the biological aspects concerned in the functional activity of the nervous system. This book covers several interesting topics concerning the central nervous system, including phospholipids, RNA synthesis, nerve impulse flow, and nerve growth factor. Comprised of 213 chapters, this book begins with an overview of the electron micrographs of calcium–ATP–phospholipid complexes. This text then examines the biochemical and histochemical studies on sectioned rat spinal cords, which demonstrated two types of monoamine-reducing drugs. Other chapters consider the diversity of antagonistic relations between the thiamine derivatives and vitamin B6, which is manifested by changes in the glutamate–GABA, histidine–histamine, tryptophan–serotonin, and tyrosine–noradrenaline systems. This book discusses as well the influence of a conditioned avoidance training experience on the incorporation of radioactive uridine into the RNA of mouse brain. The final chapter deals with the amino acid-incorporating activity of cerebral polyribosomes. This book is a valuable resource for biochemists, neurologists, pharmacologists, and biophysicists.

Research Awards Index

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Author :
language : en
Publisher:
Release Date : 1984

Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Medicine categories.