Brain Organoids In Research And Therapy
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Brain Organoids In Research And Therapy
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Author : Hans-Georg Dederer
language : en
Publisher: Springer Nature
Release Date : 2022-07-09
Brain Organoids In Research And Therapy written by Hans-Georg Dederer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-09 with Medical categories.
This volume elucidates the pivotal ethical and legal issues arising from the use of brain organoids for research, therapeutic and enhancement purposes. The function of the human brain is still a mystery. Until recently, only post-mortem tissue was available for a structural examination of the brain. Consequently, the examination results could only reflect the state at the end of life. However, in order to better understand the development and function of the human brain, dynamic and functional investigations of different human brain cells are necessary. This is where brain organoids, artificially grown in vitro miniature brains, provide the opportunity for more flexible research scenarios. At the same time, however, the use of brain organoids in research and therapy raises the question of how these new entities are to be treated from an ethical and legal point of view. Against this background, this volume aims at clarifying the normative implications of the use of brain organoids in research and therapy. The ethical reflections on the status of brain organoids, informed consent, human-to-animal chimeras and neuro-enhancement are mirrored by corresponding legal analyses. The ethical and legal assessments are preceded by an introduction to the scientific and medical background of the brain organoid technology. A final chapter will be devoted to the issue of whether international harmonization of normative standards for brain organoid research and therapy is feasible and advisable.
Organoid Technology For Disease Modelling And Personalized Treatment
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Author : Badrul Hisham Yahaya
language : en
Publisher: Springer Nature
Release Date : 2022-02-14
Organoid Technology For Disease Modelling And Personalized Treatment written by Badrul Hisham Yahaya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-14 with Science categories.
Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biology and regenerative medicine, where chimaera research, biomaterials for tissue vascularisation, gene-editing technologies, and their use in clinical procedures especially issues related to ethical concern over the use of human organoids have gotten much attention. Organoid Technology for Disease Modelling and Personalised Treatment is an excellent resource for in-depth research on one of the most interesting and significant topics in stem cell and regenerative medicine. This book's chapter collection covers a fresh viewpoint on organoid technology that scholars will require reading.
Neuroscience And Technology Innovations In Brain Research And Therapy
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Author : Aliasghar Tabatabaei Mohammadi
language : en
Publisher: Nobel Sciences
Release Date : 2023-08-29
Neuroscience And Technology Innovations In Brain Research And Therapy written by Aliasghar Tabatabaei Mohammadi and has been published by Nobel Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-08-29 with Medical categories.
Chapter 1: Artificial intelligence in Neuroscience Chapter 2: Psychedelic treatments Chapter 3: New substances that activate adrenalin receptors to relieve chronic pain Chapter 4: Advancements in neuro-technology Chapter 5: Neuroimaging Chapter 6: Organoid Therapy: Brain Organoid to rehabilitating the addicted brain
Tumor Organoids
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Author : Shay Soker
language : en
Publisher: Humana Press
Release Date : 2017-10-20
Tumor Organoids written by Shay Soker and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-20 with Medical categories.
Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.
The Emerging Field Of Human Neural Organoids Transplants And Chimeras
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Author : National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids
language : en
Publisher:
Release Date : 2021
The Emerging Field Of Human Neural Organoids Transplants And Chimeras written by National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Ethical, Legal, and Regulatory Issues Associated with Neural Chimeras and Organoids and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Cell organelles categories.
Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely lacking or only partially effective, due in large part to the difficulty of conducting brain research and the complexity of the brain itself. Researchers in recent years have developed new models to better represent and study the human brain. The three models considered in this report, all of which generate and use pluripotent stem cells from healthy individuals and patients, are human neural organoids, human neural transplants, and human-animal neural chimeras. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance reviews the status of research, considers its benefits and risks, discusses associated ethical issues, and considers governance mechanisms for this type of research.
Brain Organoid Research
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Author : Jay Gopalakrishnan
language : en
Publisher: Humana
Release Date : 2022-09-23
Brain Organoid Research written by Jay Gopalakrishnan and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-23 with Medical categories.
This volume explores multiple methods and approaches used to generate human brain and neuroretinal organoids to address fundamental questions in human brain research. The chapters in this book cover topics such as self-organizing brain organoids with ventricles amenable to injection and electroporation; visualization of 3D organoids though the latest advancements in microscopy; generation of 3D retinal tissue with physiologically competent, light-sensitive photoreceptors; modeling brain tumors using genetically edited brain organoids; and brain organoids as a model to study Zika virus and SARS-CoV-2 infections. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Brain Organoid Research is a valuable resource for researchers at various levels of learning, ranging from undergraduate students, early researchers, and advanced laboratories. This book aims to be instrumental in moving this developing field forward.
Cognitive Impairment Therapy Momentum In The Continuum Of Life
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Author : Artemissia-Phoebe Nifli
language : en
Publisher: Frontiers Media SA
Release Date : 2021-03-09
Cognitive Impairment Therapy Momentum In The Continuum Of Life written by Artemissia-Phoebe Nifli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-09 with Science categories.
Organoids And Mini Organs
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Author : Jamie Davies
language : en
Publisher: Academic Press
Release Date : 2018-03-09
Organoids And Mini Organs written by Jamie Davies and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-09 with Science categories.
Organs and Organoids combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved. Collects the best protocols of organoid cultures from diverse tissues Covers a wide range of organs Includes troubleshooting cases for common, but specific problems for each culture conditions Provides an entire section on the application of organoids
Human Embryonic Stem Cells
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Author : Arlene Chiu
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-08
Human Embryonic Stem Cells written by Arlene Chiu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08 with Science categories.
A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.
Human Neural Stem Cells
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Author : Leonora Buzanska
language : en
Publisher: Springer
Release Date : 2018-09-12
Human Neural Stem Cells written by Leonora Buzanska and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-12 with Science categories.
This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.