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Brainage


Brainage
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Brainage


Brainage
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Author : Katja Franke
language : en
Publisher: Sudwestdeutscher Verlag Fur Hochschulschriften AG
Release Date : 2014-09-09

Brainage written by Katja Franke and has been published by Sudwestdeutscher Verlag Fur Hochschulschriften AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-09 with categories.


Based on the widespread but well-ordered brain tissue loss that occurs with healthy aging into senescence, this work presents a novel magnetic resonance imaging (MRI)-based biomarker, which identifies normal and abnormal aging-related brain atrophy. The novel BrainAGE approach is based on a database of structural MRI data, aggregating the complex, multidimensional aging patterns across the whole brain to one single value, i.e. the estimated brain age. Consequently, subtle deviations in "normal" brain atrophy can be directly quantified in terms of years by analyzing one standard MRI scan per subject. Various neuro-degenerative diseases - especially Alzheimer's disease (AD) - are widely linked to advanced brain aging. The BrainAGE approach is applied to identify advanced brain aging in subjects with mild cognitive impairment and AD, to predict conversion to AD, to relate individual BrainAGE scores with disease severity and prospective worsening of cognitive functions. Furthermore, BrainAGE identifies various risk factors of pathological brain aging that may precede the onset of clinical symptoms (e.g., diabetes mellitus type 2, metabolic syndrome).



Advances Of Neuroimaging And Data Analysis


Advances Of Neuroimaging And Data Analysis
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Author : Jue Zhang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-05

Advances Of Neuroimaging And Data Analysis written by Jue Zhang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-05 with categories.




Discovering Yourself In The Brain Age


Discovering Yourself In The Brain Age
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Author : National Institute of Neurological Diseases and Stroke
language : en
Publisher:
Release Date : 1973

Discovering Yourself In The Brain Age written by National Institute of Neurological Diseases and Stroke and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Brain categories.




The Effect Of The Apoe Genotype On Individual Brainage In Normal Aging Mild Cognitive Impairment And Alzheimer S Disease


The Effect Of The Apoe Genotype On Individual Brainage In Normal Aging Mild Cognitive Impairment And Alzheimer S Disease
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Author : Luise Christine Löwe
language : en
Publisher:
Release Date : 2016

The Effect Of The Apoe Genotype On Individual Brainage In Normal Aging Mild Cognitive Impairment And Alzheimer S Disease written by Luise Christine Löwe and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.




Individualized Assessment Of Brain Aging Across The Lifespan Applications In Health And Disease


Individualized Assessment Of Brain Aging Across The Lifespan Applications In Health And Disease
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Author : Katja Franke
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-10

Individualized Assessment Of Brain Aging Across The Lifespan Applications In Health And Disease written by Katja Franke and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-10 with categories.




Nutrition And Prevention Of Alzheimer S Disease


Nutrition And Prevention Of Alzheimer S Disease
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Author : Claudia Perez-Cruz
language : en
Publisher: Frontiers Media SA
Release Date : 2015-12-18

Nutrition And Prevention Of Alzheimer S Disease written by Claudia Perez-Cruz and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-18 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.


Altered metabolism is known to be associated with a higher incidence of Alzheimer´s disease (AD). Diabetes type 2, obesity, and metabolic syndrome are considered risk factors for the development of dementias, including AD. These metabolic diseases may have a genetic predisposition, but most of them are caused by environmental factors and life-style. Most research has focused on the effect of a high-fat diet (HFD) and sweetened beverages that induce obesity. Importantly, a HFD can also trigger oxidative stress, neuro-inflammation and cognitive decline. Less is known, however, about beneficial effects of diet on cognition, such as slowing the progression or preventing AD by ingesting whole fruits, vegetables, fish and oil. It is important to highlight the difference between vitamin/mineral supplements and whole food, as it appears that the former are clinically ineffective, while multiple ingredients in the latter act synergistically to improve cognition. As AD is a disease of slow progression, therapies should start several decades before clinical symptoms can be observed; one strategy can be the ingestion of healthy food in those subjects with one or more risk factors (genetic, environmental, life-style) already in their 40s, just when some brain metabolic disturbances start to develop. This dietary therapy can overcome the increased reactive oxygen species, protein deposition and synaptic failure, characteristic of AD. This research topic will cover a range of research articles, case studies, opinion and mini-reviews, all focused on describing the damaging effects of an industrial diet on cognition as well as on highlighting the beneficial effects of a healthy diet to prevent AD. We believe that we still have time to fight against the negative impact of our industrialized cultures, and adopt better eating habits, increase exercise and slow down our life style to prevent increasing dementia in the aging population. Also, all these topics has been a product of intensives investigations, with a great life hope, and we hope you all enjoy reading this e-book.



Brain Games Lower Your Brain Age In Minutes A Day


Brain Games Lower Your Brain Age In Minutes A Day
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Author : Publications International Ltd
language : en
Publisher:
Release Date : 2006-11-21

Brain Games Lower Your Brain Age In Minutes A Day written by Publications International Ltd and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-21 with Games & Activities categories.


"Scientists have found that giving your brain a workout can be just as important as diet and exercise in preserving your mental and physical strength. So keep your mind feeling young and fit with Brain Games : Lower your brain age in minutes a day. It's crammed with puzzles of many types that are designed to stimulate different parts of the brain -- fun puzzles that may help keep your bain strong and firing on all cylinders."--Cover.



Brain Games 3 Lower Your Brain Age In Minutes A Day


Brain Games 3 Lower Your Brain Age In Minutes A Day
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Author :
language : en
Publisher: Publications International
Release Date : 2007-10-01

Brain Games 3 Lower Your Brain Age In Minutes A Day written by and has been published by Publications International this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-01 with Games categories.


Brain Games is crammed with puzzles designed to stimulate each of your brain's cognitive functions, keeping it strong and fit. Many different types of puzzles are included, and each of the five levels increases the challenge of solving them. With these puzzles, exercising your brain can be fun!



Modifiable Risk Factors Of Accelerated Brain Aging And Dementia


Modifiable Risk Factors Of Accelerated Brain Aging And Dementia
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Author : Frauke Beyer
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-29

Modifiable Risk Factors Of Accelerated Brain Aging And Dementia written by Frauke Beyer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-29 with Science categories.




Alzheimer Resemblance Atrophy Index Brainage And Normal Pressure Hydrocephalus Score In The Prediction Of Subtle Cognitive Decline Added Value Compared To Existing Mr Imaging Markers


Alzheimer Resemblance Atrophy Index Brainage And Normal Pressure Hydrocephalus Score In The Prediction Of Subtle Cognitive Decline Added Value Compared To Existing Mr Imaging Markers
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Author : Panteleimon Giannakopoulos
language : en
Publisher:
Release Date : 2022

Alzheimer Resemblance Atrophy Index Brainage And Normal Pressure Hydrocephalus Score In The Prediction Of Subtle Cognitive Decline Added Value Compared To Existing Mr Imaging Markers written by Panteleimon Giannakopoulos and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.


Abstract: Objectives Established visual brain MRI markers for dementia include hippocampal atrophy (mesio-temporal atrophy MTA), white matter lesions (Fazekas score), and number of cerebral microbleeds (CMBs). We assessed whether novel quantitative, artificial intelligence (AI)-based volumetric scores provide additional value in predicting subsequent cognitive decline in elderly controls. Methods A prospective study including 80 individuals (46 females, mean age 73.4 ± 3.5 years). 3T MR imaging was performed at baseline. Extensive neuropsychological assessment was performed at baseline and at 4.5-year follow-up. AI-based volumetric scores were derived from 3DT1: Alzheimer Disease Resemblance Atrophy Index (AD-RAI), Brain Age Gap Estimate (BrainAGE), and normal pressure hydrocephalus (NPH) index. Analyses included regression models between cognitive scores and imaging markers. Results AD-RAI score at baseline was associated with Corsi (visuospatial memory) decline (10.6% of cognitive variability in multiple regression models). After inclusion of MTA, CMB, and Fazekas scores simultaneously, the AD-RAI score remained as the sole valid predictor of the cognitive outcome explaining 16.7% of its variability. Its percentage reached 21.4% when amyloid positivity was considered an additional explanatory factor. BrainAGE score was associated with Trail Making B (executive functions) decrease (8.5% of cognitive variability). Among the conventional MRI markers, only the Fazekas score at baseline was positively related to the cognitive outcome (8.7% of cognitive variability). The addition of the BrainAGE score as an independent variable significantly increased the percentage of cognitive variability explained by the regression model (from 8.7 to 14%). The addition of amyloid positivity led to a further increase in this percentage reaching 21.8%. Conclusions The AI-based AD-RAI index and BrainAGE scores have limited but significant added value in predicting the subsequent cognitive decline in elderly controls when compared to the established visual MRI markers of brain aging, notably MTA, Fazekas score, and number of CMBs