Brucella Molecular Cell Biol
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Brucella Molecular Cell Biol
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Author : Ignacio Lopez-Goni
language : en
Publisher: Taylor & Francis
Release Date : 2005-11-08
Brucella Molecular Cell Biol written by Ignacio Lopez-Goni and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-08 with Science categories.
The book opens with chapters that focus on the development of molecular diagnostic tools and these are followed by chapters on genetic evolution and its relationship to pathogenicity. Other topics include Brucella comparative genomics and proteomics, analysis of the structure, biosynthesis and biology of glucans and lipopolysaccharides, pathogenicity, approaches to vaccine development, bacterium-host interactions, immune response, and much more. Essential reading for everyone with an interest in Brucella and brucellosis and recommended reading for the wider body of scientists with an interest in microbial diagnostics, microbial pathogenesis, cellular microbiology and immunology, and vaccine development.
Brucella
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Author : Ignacio López-Goñi
language : en
Publisher: Taylor & Francis
Release Date : 2004
Brucella written by Ignacio López-Goñi and has been published by Taylor & Francis this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.
The book opens with chapters that focus on the development of molecular diagnostic tools and these are followed by chapters on genetic evolution and its relationship to pathogenicity. Other topics include Brucella comparative genomics and proteomics, analysis of the structure, biosynthesis and biology of glucans and lipopolysaccharides, pathogenicity, approaches to vaccine development, bacterium-host interactions, immune response, and much more. Essential reading for everyone with an interest in Brucella and brucellosis and recommended reading for the wider body of scientists with an interest in microbial diagnostics, microbial pathogenesis, cellular microbiology and immunology, and vaccine development.
Brucella
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Author : Ignacio López-Goñi
language : en
Publisher: Caister Academic Press Limited
Release Date : 2012
Brucella written by Ignacio López-Goñi and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Science categories.
Brucella is a genus of Gram-negative, facultative, intracellular bacteria that are highly pathogenic for a variety of mammals, including humans. Recently, the World Health Organization cited brucellosis to be the world's most widespread zoonosis. An important feature of the pathogenicity of these organisms is their ability to survive and replicate within the host macrophages. However, the mechanism for this is unclear. In addition, none of the classical bacterial virulence factors found in other bacterial pathogens have been found in the genomes of the 40 Brucella species and biovars analyzed to date. Nevertheless, the application of systems biology approaches in recent years has transformed research, permitting fascinating new insights into Brucella molecular biology and genomics. Written by highly acclaimed Brucella scientists, this book comprehensively reviews the most important advances in the field. The opening chapters focus on genetic diversity within Brucella, covering both classical and new species. Particular emphasis is given to how comparative genomics has led to advances in molecular diagnostics, taxonomy, and phylogeny. Additional chapters cover proteomic analysis, transcriptomic analysis, the VirB type IV secretion system, signaling complexes - e.g. the BvrR/BvrS two-component regulatory system and quorum sensing. These chapters highlight the intricate interplay between factors involved in virulence. Another chapter discusses the role of the Brucella cell envelope in bacterial virulence and evasion of host defenses, and the final two chapters review the current strategies for the development of novel antibacterial agents and improved vaccines. This volume is essential reading for everyone with an interest in Brucella and brucellosis. It is also recommended for cellular microbiologists and immunologists, and vaccine development scientists, as well as a wider body of scientists, veterinarians, and MDs with an interest in microbial diagnostics, microbial pathogenesis, and host-parasite interactions.
Metals And The Biology And Virulence Of Brucella
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Author : R. Martin Roop II
language : en
Publisher: Springer
Release Date : 2017-08-09
Metals And The Biology And Virulence Of Brucella written by R. Martin Roop II and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-09 with Science categories.
This book summarises the current knowledge on the role played by biologically relevant transition metals (Fe, Mn, Zn, Ni, Co, Cu and Mg) in the basic biology and virulence of bacterial pathogens from the genus Brucella. The authors explore the biological functions of these metals, how these bacteria compete with their mammalian hosts for these metals and how they avoid metal toxicity. Researchers and professionals studying zoonotic pathogens from the genus Brucella find this book valuable.
Updates On Brucellosis
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Author : Manal Mohammad Baddour
language : en
Publisher: BoD – Books on Demand
Release Date : 2015-11-19
Updates On Brucellosis written by Manal Mohammad Baddour and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-19 with Medical categories.
Brucellosis is a major zoonotic disease that may cause a serious illness in humans and animals. Global prevalence of human brucellosis remains significant. More than half a million new brucellosis cases from 100 countries are reported annually to the World Health Organization (WHO). The majority of these cases are reported in developing countries.In humans, brucellosis (undulant fever, Malta fever) is characterized by an acute bacteremic phase followed by a chronic stage that may extend over many years and may involve many tissues. It is a systemic disease, and many organ systems (nervous system, heart, skeletal system, bone marrow, etc.) may become involved following hematogenous dissemination. Although eradicated in some countries, it remains one of the most economically important zoonosis worldwide as it is responsible for huge economic losses as well as significant human morbidity in endemic areas. Because of the nonspecific clinical manifestations of human brucellosis and the need for prolonged combination therapy with antibiotics that are not routinely prescribed for other infectious diseases, laboratory confirmation of the diagnosis is of paramount importance for adequate patient management. In addition, evidence of brucellosis has serious public health implications because it discloses exposure to a contaminated source (infected animals or their products, unsafe laboratory practices, or a potential biological warfare attack). This book addresses human brucellosis with stress on symptoms including those related to the less recognized disease localizations, risk of exposure, treatment, and prevention. Light is shed on animal brucellosis as it pertains to human exposure. The book also emphasizes on laboratory procedures in culturing and serologic techniques. Epidemiologic surveillance is among this books subjects as well as veterinary control measures.
Brucella Melitensis
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Author : Jangampalli Adi Pradeepkiran
language : en
Publisher: Academic Press
Release Date : 2021-03-03
Brucella Melitensis written by Jangampalli Adi Pradeepkiran and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-03 with Medical categories.
Brucella Miletensis: Identification and Characterization of Potential Drug Targets presents a systematic approach to identifying and characterizing drug targets using bioinformatics. The book shows the potential of bioinformatic tools in the identification of virulence targets in pathogenic bacteria and viruses, in general, and in B. militensis 16M in particular. Chapters identify putative genes as potential drug targets, employ a subtractive genomic approach, consider the virulent genes of this bacteria that negatively affects humans, list twelve potential virulence genes as drug targets, and consider the screening of potential drugs against the bacteria’s virulence genes through molecular modeling, computational screening, drug discovery and molecular docking studies. In addition, the book demonstrates in silico approaches that offer insights into the identification of drug targets in B.melitensis 16M. The title employs a step-by-step approach to understanding drug targets by identifying and characterizing vaccine targets for Brucella melitensis, in silico screening, and the identification of novel drug targets from the total Brucella melitensis proteome. Other sections cover computational modeling and evaluation of the best potential drug targets through comparative modeling, molecular docking, and dynamics simulations of novel drug targets and in silico validation and ADMET analysis for best lead molecules. Covers the identification and characterization of vaccine targets for Brucella melitensis Presents in silico screening and the identification of novel drug targets Gives computational modeling and evaluations for potential drug targets Offers molecular docking and dynamics simulations for novel drug targets Details in silico validation and ADMET analysis for best lead molecules
Electroporation Protocols For Microorganisms
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Author : Jac A. Nickoloff
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Electroporation Protocols For Microorganisms written by Jac A. Nickoloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
Electroporation is one of the most widespread techniques used in modem molecular genetics. It is most commonly used to introduce DNA into cells for investigations of gene structure and function, and in this regard, electroporation is both highly versatile, being effective with nearly all species and cell types, and highly efficient. For many cell types, electroporation is either the most efficient or the only means known to effect gene transfer. However, exposure of cells to brief, hi- intensity electric fields has found broad application in other aspects of biological research, and is now routinely used to introduce other types of biological and analytic molecules into cells, to induce cell-cell fusion, and to transfer DNA directly between different species. The first seven chapters of Electroporation Protocols for Micro organisms describe the underlying theory of electroporation, the com mercially available instrumentation, and a number of specialized electroporation applications, such as cDNA library construction and interspecies DNA electrotransfer. Each of the remaining chapters pre sents a well developed method for electrotransformation of a particular bacterial, fungal, or protist species. These chapters also serve to intro duce those new to the field the important research questions that are currently being addressed with particular organisms, highlighting both the major advantages and limitations of each species as a model organ ism, and explaining the roles that electroporation has played in the development of the molecular genetic systems currently in use.
Brucellosis
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Author : Edward J. Young
language : en
Publisher: CRC Press
Release Date : 1989-05-31
Brucellosis written by Edward J. Young and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-05-31 with Science categories.
Fourteen brucellosis experts from seven countries discuss the history, epidemiology, microbiology, immunology, diagnosis, treatment, and control of brucellosis in animals and man. Edited by members of the World Health Organization's Expert Committee on Brucellosis, this text is the first comprehensive treatment of the disease since The Nature of Brucellosis by Wesley W. Spink in 1956. Topics reviewed with current references include infection caused by newer species of Brucella, such as B. canis, newer diagnostic techniques, such as radioimmunoassay and ELISA, and newer treatments, such as rifampin and the quinolones. The pathogenesis and pathophysiology of brucellosis is reviewed in depth, correlating the disease in animals with the illness in humans. This volume is extremely useful for clinicians, researchers, and students in medicine, veterinary science, microbiology, immunology, epidemiology, public health, and international health.
Cellular Microbiology
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Author : Pascale Cossart
language : en
Publisher:
Release Date : 2005
Cellular Microbiology written by Pascale Cossart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Bacterial genomes categories.
A comprehensive examination of this burgeoning area of important research.
Animal Brucellosis
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Author : Klaus Nielsen
language : en
Publisher: CRC Press
Release Date : 2018-01-10
Animal Brucellosis written by Klaus Nielsen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-10 with Medical categories.
This timely publication updates and standardizes currently used diagnostic procedures for this widespread, economically costly livestock disease. It includes state-of-the-art technology, now in limited use, which will replace the conventional methodology in the near future. The volume covers research done on improved diagnostic techniques, vaccines, taxonomy, epidemiology, pathology, and basic immunology. It is an important literature review for those more established in this field and serves as a guide to researchers or diagnosticians becoming involved with this disease.