Calcium In Cell Cycles And Cancer
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Calcium In Cell Cycles And Cancer
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Author : James F. Whitfield
language : en
Publisher: CRC Press
Release Date : 1995-04-24
Calcium In Cell Cycles And Cancer written by James F. Whitfield and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-24 with Medical categories.
The second edition of Calcium in Cell Cycles and Cancer presents a unique overview of calcium's roles in the several stages of cell cycles initiated by signals from "velcroceptors" and other kinds of growth-factor receptors. This book integrates the actions of calcium and its partner, cyclic AMP, with those of the growing family of newly discovered, stage-specific, cyclin-dependent protein kinases of the "cell cycle engine." The book also shows calcium to be a terminal, ultimately apoptogenic differentiator of colon and skin cells, as well as a major player in lymphocyte selection, activation, and proliferation. This edition relates and explains the dramatic changes in calcium's involvement in the cell cycle and the triggering of terminal differentiation programs that happen during carcinogenesis and are important keys to understanding cancer.
Calcium Cell Cycles And Cancer
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Author : James F. Whitfield
language : en
Publisher: CRC PressI Llc
Release Date : 1990
Calcium Cell Cycles And Cancer written by James F. Whitfield and has been published by CRC PressI Llc this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.
Whitfield (head of the cellular oncology group of the National Research Council of Canada) provides a critical and comprehensive survey of the known relationships between calcium, cell cycles, and cancer. A major theme is that calcium works with the regulator, cyclic AMP, to send five distinct signals that trigger the cycle ending in the cell's nuclear reconstruction. This is demonstrated through in- depth examinations of various cell cycles. On this foundation, he presents an extensive discussion of the changes in the signaling mechanisms and the loosening of their hold on cell cycle events that are key parts of the multistage carcinogenic process. Of interest to biochemists, cell biologists, pharmacologists, physiologists, and clinicians. Annotation copyrighted by Book News, Inc., Portland, OR
Calcium Signalling In Cancer
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Author : G. V. Sherbet
language : en
Publisher: CRC Press
Release Date : 2000-11-29
Calcium Signalling In Cancer written by G. V. Sherbet and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-29 with Medical categories.
Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feat
Calcium
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Author : James F. Whitfield
language : en
Publisher: New York : Springer
Release Date : 1997-01-01
Calcium written by James F. Whitfield and has been published by New York : Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-01-01 with Apoptosis categories.
To understand cancer we must know how Ca2+ drives cell cycles and how and why cells lose Ca2+ control while climbing the steps to cancer. This book presents a much needed and concise, but wide-ranging overview of what we know about the several different roles of Ca2+ in starting, and subsequently driving, the major cell cycle transitions. Also explored is the differentiation-apoptosis (diffpoptosis) of two exemplary cell systems - colon and skin. The information should inspire the reader to become intrigued about the possibilities on the horizon for Ca2+ in cancer research. The main goal of the book is to encourage young readers to follow the tantalizing leads presented and continue their research in the field.
Calcium
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Author : James F. Whitfield
language : en
Publisher: NRC Research Press
Release Date : 2001
Calcium written by James F. Whitfield and has been published by NRC Research Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.
This volume provides a lucid state-of-the-art tour of the critical signaling roles calcium plays in both the normal and carcinogenic cell cycles of proliferation, differentiation, and death. Whitfield and Chakravarthy (Institute for Biological Sciences, National Research Council of Canada, Ottawa) commence their discussion with the intriguing comment that no revolution has had as much an impact on Earth as the Great Calcium-Driven Eukaryotic Revolution occurring soon after the planet's birth. The final chapter explains how calcium also drives responsiveness in plants. Includes exceptionally well-referenced chapters, crisp color graphics, and a bilingual French-English abstract. Annotation copyrighted by Book News Inc., Portland, OR.
Calcium Calmodulin Dependent Kinases Participate In The Cell Cycle Regulation And Antiapoptotic Mechanisms In Mcf 7 Human Breast Cancer Cells
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Author : Oswaldo Giovanny Rodriguez-Mora
language : en
Publisher:
Release Date : 2005
Calcium Calmodulin Dependent Kinases Participate In The Cell Cycle Regulation And Antiapoptotic Mechanisms In Mcf 7 Human Breast Cancer Cells written by Oswaldo Giovanny Rodriguez-Mora and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Ions Cell Proliferation And Cancer
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Author : Alton L. Boynton
language : en
Publisher: Academic Press
Release Date : 2013-09-17
Ions Cell Proliferation And Cancer written by Alton L. Boynton and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-17 with Health & Fitness categories.
Ions, Cell Proliferation, and Cancer present the credibility of ions as specific regulators of cell proliferation. This book provides an understanding of the control of cell proliferation and the deregulated proliferation of cancer cells. Organized into three sections encompassing 32 chapters, this book begins with an overview of the important role that ions in animal cells play in a variety of fundamental processes associated with essential cell functions. This text then examines the relationship between ionic events and cellular production, specifically in mammalian cell systems. Other chapters consider the development of atomic absorption spectrophotometry as a method for measuring inorganic cations. This book discusses as well the two widely applicable methods for measuring free concentrations of ions inside cells. The final chapter deals with magnesium ion as the most abundant divalent action in living cells. This book is a valuable resource for animal cell biologists, molecular biologists, and research workers.
Trends In Stem Cell Proliferation And Cancer Research
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Author : Rodrigo R. Resende
language : bn
Publisher: Springer Science & Business Media
Release Date : 2013-08-13
Trends In Stem Cell Proliferation And Cancer Research written by Rodrigo R. Resende and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-13 with Medical categories.
The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance
Regulation Of The Calcium Calmodulin Dependent Kinase Cascade In Human Breast Cancer Cells
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Author :
language : en
Publisher:
Release Date : 1998
Regulation Of The Calcium Calmodulin Dependent Kinase Cascade In Human Breast Cancer Cells written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
The regulation of the CaM KI signaling pathway will be studied in human breast cancer cell lines. We hypothesize that CaM KI phosphorylation of the transcription factor, CREB is a key regulatory step in cell cycle regulation and/or prevention of apoptosis. Since tamoxifen (TAM) causes cell cycle arrest and apoptosis in breast cancer cells, we thought that part of TAM's effects may be mediated by inhibition of the CaM kinase cascade. Regardless if this is the case, CaM inhibitors cause cell cycle arrest and apoptosis in many tumor cells. Hence, CaM and its targets are potential sites of therapeutic intervention. We have found that TAM does not inhibit CaM activation of CaM KI as originally proposed. We have found, however, that Ca2+ not only modulates the phosphorylation of S133 of CREB, but also CREB binding protein (CBP) transactivation. In characterizing the mechanism of CaM KI activation by CaM KI, we found that the substrate specificity of CaM KI changes upon T177 phosphorylation by CaM KI. These data will be very relevant to how CaM KI can function in breast cancer cells, particularity if different substrates require alternate modes of enzyme activation. As cells reenter the cell cycle from growth arrest, CaM KI expression dramatically peaks. It will be interesting to see at which stages during the cell cycle CaM KI is functionally important and whether these stages are compromised in our human breast cancer cell lines.
Progress In Cell Cycle Research
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Author : Laurent Meijer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Progress In Cell Cycle Research written by Laurent Meijer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The latest volume in this highly regarded series covers current advances in the fast-moving field of cell cycle research by gathering reviews otherwise scattered throughout the literature. Contributions encompass fields from cell and molecular biology to biochemistry.