Calcium Signalling In Cancer
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Calcium Signalling In Cancer
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Author : G. V. Sherbet
language : en
Publisher: CRC Press
Release Date : 2000-11-29
Calcium Signalling In Cancer written by G. V. Sherbet and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-29 with Science categories.
Calcium signalling occupies a preeminent position in the signal transduction system of the cell by virtue of its participation in a wide range of physiological functions together with the biological events associated with genetic expression, cell proliferation and apoptosis, as well as cell differentiation and morphogenesis. It is an important feature of cell adhesion and motility; the integrity of the calcium binding proteins themselves is a basic requirement of normal biological function. In fact, the deregulation of calcium signaling is now regarded as the primary event in the pathogenesis, growth, invasion, and secondary spread of cancer. Calcium Signalling in Cancer is a concise up-to-date treatise on the transduction signals induced by calcium that considers how alterations in this calcium-dependent signal transduction pathway are related to a number of human diseases, especially neoplastic transformation. This authoritative text examines a broad range of topics-from mechanisms and significance of calcium homeostasis for normal cell function to calcium signalling pathways and the transduction of the calcium signal, especially in proliferation, cell motility, cancer invasion,, and metastasis. Clearly organized, it covers all aspects of the subject including specific sections on the regulation of the genes whose products are required for signal transduction by calcium, such as Alzheimer's disease, Darier's disease, Duchenne and limb girdle dystrophies, psoriasis and some forms of ichthyosis, and cancer associated retinopathy. With an extensive bibliography and over 2,500 references, Calcium Signalling in Cancer is an invaluable reference source.
Calcium Signaling From Physiology To Diseases
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Author : Senthilkumar Rajagopal
language : en
Publisher: Springer
Release Date : 2017-09-28
Calcium Signaling From Physiology To Diseases written by Senthilkumar Rajagopal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-28 with Science categories.
This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.
Calcium Signaling
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Author : Md. Shahidul Islam
language : en
Publisher: Springer Nature
Release Date : 2019-10-23
Calcium Signaling written by Md. Shahidul Islam and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-23 with Medical categories.
This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative. The chapter “Calcium Signaling: From Basic to Bedside” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Calcium In Cell Cycles And Cancer
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Author : James F. Whitfield
language : en
Publisher: CRC Press
Release Date : 1995-04-24
Calcium In Cell Cycles And Cancer written by James F. Whitfield and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-24 with Medical categories.
The second edition of Calcium in Cell Cycles and Cancer presents a unique overview of calcium's roles in the several stages of cell cycles initiated by signals from "velcroceptors" and other kinds of growth-factor receptors. This book integrates the actions of calcium and its partner, cyclic AMP, with those of the growing family of newly discovered, stage-specific, cyclin-dependent protein kinases of the "cell cycle engine." The book also shows calcium to be a terminal, ultimately apoptogenic differentiator of colon and skin cells, as well as a major player in lymphocyte selection, activation, and proliferation. This edition relates and explains the dramatic changes in calcium's involvement in the cell cycle and the triggering of terminal differentiation programs that happen during carcinogenesis and are important keys to understanding cancer.
Calcium Signalling And Disease
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Author : Ernesto Carafoli
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-29
Calcium Signalling And Disease written by Ernesto Carafoli and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-29 with Medical categories.
Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Calcium And Signal Transduction
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-24
Calcium And Signal Transduction written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-24 with Science categories.
Since the development of microelectronic clamping methodology and fluorescent indicators for direct measurement of dynamic intracellular calcium transients, our understanding of biological signal transduction has progressed dramatically since the 1980s. Calcium is a universal signal in biology that modulates gene expression, transmitter and hormone release, muscular movement, and even "programmed" cell death. This book represents a compilation of chapters from a diverse set of expert biologists throughout the world who have conducted research in the general area of calcium signaling in organisms ranging from bacteria to humans. In accord with priorities of resolving human disease, the reader will also benefit from learning calcium's role in cellular signaling pathology relating to acute or chronic conditions such as vomiting, sepsis, obesity, hypertension, and cancer.
Calcium Signaling In Human Health And Diseases
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Author : Francesco Moccia
language : en
Publisher: MDPI
Release Date : 2019-01-21
Calcium Signaling In Human Health And Diseases written by Francesco Moccia and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-21 with Biochemistry categories.
This book is a printed edition of the Special Issue "Calcium Signaling in Human Health and Diseases" that was published in IJMS
Calcium Entry Channels In Non Excitable Cells
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Author : Juliusz Ashot Kozak
language : en
Publisher: CRC Press
Release Date : 2017-07-14
Calcium Entry Channels In Non Excitable Cells written by Juliusz Ashot Kozak and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Science categories.
Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.
Chemosensitivity
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Author : Rosalyn D. Blumenthal
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Chemosensitivity written by Rosalyn D. Blumenthal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
A state-of-the art collection of readily reproducible laboratory methods for assessing chemosensitivity in vitro and in vivo, and for assessing the parameters that modulate chemosensitivity in individual tumors. Chemosensitivity, Volume 1: In Vitro Assays provides a panel of 16 in vitro measures of chemosensitivity in adherent and non-adherent cells for single agents and combinations of agents. In addition to immunohistochemical and imaging approaches, these assays include clonogenic, colorimetric, fluorometric, and physiological assays. Highlights include image analysis to assess drug sensitivity, high throughput approaches using green fluorescent protein, DIMSCAN (a microcomputer fluorescence-based assay), and the ChemoFx assay used in biotechnology. A companion volume, Volume 2: In Vivo Models, Imaging, and Molecular Regulators, provides protocols for classifying tumors into response categories and customizing chemotherapy regimens to individual patients.
Autophagy And Cancer
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Author : Hong-Gang Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-30
Autophagy And Cancer written by Hong-Gang Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-30 with Medical categories.
With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.