Cancer Chemoprevention
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Cancer Chemoprevention
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Author : Gary J. Kelloff
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-17
Cancer Chemoprevention written by Gary J. Kelloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-17 with Medical categories.
Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.
Cancer Chemoprevention
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Author : Lee Wattenberg
language : en
Publisher: CRC Press
Release Date : 1992-08-20
Cancer Chemoprevention written by Lee Wattenberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-08-20 with Medical categories.
The ultimate goal of cancer chemoprevention research and development is the identification of pharmaceutical or dietary constituents that will prevent cancer. Cancer Chemoprevention presents the proceedings of a large workshop on cancer chemoprevention that highlights the latest knowledge in the field, in addition to issues and ideas concerning future directions. Retinoids, sulfur compounds, and a large number of many naturally occurring cancer inhibitors in the diet are discussed, including green tea, garlic constituents, citrus fruit oils, and beans and seeds containing protease inhibitors. Compounds that may prevent the formation of carcinogens in food are covered, and the mechanisms by which chemical or dietary agencts produce cancer inhibitors are discussed.
Chemoprevention Of Cancer
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Author : H.-J. Senn
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chemoprevention Of Cancer written by H.-J. Senn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Pharmacologic interventions to prevent the evolution of human cancers are still in its infancy, although a good number o- mostly controlled - clinical studies have been performed in the past two decades. However, regarding the partially stagnating therapeutic results of major epithelial cancer types such as breast-, lung-, colon- and ENT-cancer types, the problem of in terference with the evolution of disease at a preclinical level is an intriguing one, and the field seems to develop into one of the fastest growing domaines of modern oncology. This process is fa cilitated by the developments of molecular on co-genetics and the gowing existence of family cancer units, allowing to better identi fy and inform respective high risk groups, thus enabling re searchers and clinicians to more realistically target their chemo preventive efforts to the true populations at risk. On this changing background, the newly formed International Society of Cancer Chemoprevention (ISCaC) together with the Swiss Cancer League and the Interdisciplinary Oncology Center of St. Gallen/Switzerland organized an international Symposium in September 1997, inviting basic researchers, epidemiologists and clinical oncologists of related disciplines to discuss pertinent issues of experimental and clinical chemo- and bio-prevention in a scientific workshop.
Cancer Chemoprevention
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Author : Raymond C. Bergan
language : en
Publisher: Springer
Release Date : 2001
Cancer Chemoprevention written by Raymond C. Bergan and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medical categories.
Great advances were made in the pharmacologic-based treatment of cancer in prior decades. However, despite a marked increase in our understanding ofcell and molecular mechanisms underlying the neoplastic process, therapy for advanced disease remains limited. While the reasons for this are many, it is generally accepted that advanced neoplasms contain a relatively large number of genetic and molecularalterations contributingto the maintenanceofthe neoplastic process. Such a situation precludes easy pharmacologic intervention. However, our ability to detect cancer at an earlier stage, coupled with our increased understandingofcarcinogenesis, are propellingboth basic and clinical scientiststo pursue early intervention/chemopreventive approaches. This is based upon the notion that fewer molecularaberrations are presentearlyon inthedisease process. It also takes advantage ofthe fact that advances in both technology, and in the field ofcancer biology, coupled with a heightened vigilance, have increased our ability to detect early disease more readily. The chemopreventive approach is highly attractive for a number ofreasons. First, treatment ofpre-neoplastic, or early neoplastic, lesions would prevent the significant mobility and mortality associated with advanced neoplastic disorders.
Natural Products For Cancer Chemoprevention
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Author : John M. Pezzuto
language : en
Publisher: Springer Nature
Release Date : 2020-04-03
Natural Products For Cancer Chemoprevention written by John M. Pezzuto and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-03 with Medical categories.
This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.
Cancer Chemoprevention
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Author : Gary J. Kelloff
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-06-04
Cancer Chemoprevention written by Gary J. Kelloff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-04 with Medical categories.
Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.
Critical Dietary Factors In Cancer Chemoprevention
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Author : Mohammad Fahad Ullah
language : en
Publisher: Springer
Release Date : 2015-10-06
Critical Dietary Factors In Cancer Chemoprevention written by Mohammad Fahad Ullah and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-06 with Science categories.
This book focuses on the prophylactic potential of diet-derived factors in primary prevention of cancer. It is written by a group of highly reputed experts in the area of dietary agents and cancer chemoprevention. The translational potential of dietary factors from epidemiological, laboratory and clinical studies as prevention strategy in normal and risk populations is highlighted. The work presents options of routine inclusion of specific dietary regimens for prevention as well as therapeutic strategy for better management through adjuvant interventions in cancer treatment.
Chemoprevention Of Cancer
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Author : Daniel W. Nixon
language : en
Publisher: CRC Press
Release Date : 1994-11-08
Chemoprevention Of Cancer written by Daniel W. Nixon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-11-08 with Medical categories.
Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.
Cancer And Chemoprevention An Overview
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Author : Summya Rashid
language : en
Publisher: Springer
Release Date : 2017-07-05
Cancer And Chemoprevention An Overview written by Summya Rashid and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-05 with Medical categories.
This book focuses on the most recent, relevant, comprehensive and significant advances in cancer and chemo prevention. It broadly discusses cancer, its hallmarks and classification, molecular mechanisms of outbreak, contributing factors, role of oxidative stress, inflammatory mediators and evading apoptosis, which leads to the progression of disease. Though modern medicine has left us with no option to treat this deadly disease due to drawbacks associated with conventional treatment – like its non-targeted nature, drug resistance, varied organ toxicities and unaffordability – chemoprevention offers a viable therapeutic window. Given chemoprevention’s importance in the present scenario, the book highlights various chemo preventive strategies currently used in the management of cancer; a selection of novel chemo preventive agents used at clinics and in the pre-clinical stage; hurdles to effective chemoprevention; future prospects and the road ahead. It offers a valuable guide for all graduate students and researchers seeking information on cancer and chemoprevention in general, irrespective of the specific type/pathways involved in its onset.
Cancer Chemoprevention And Treatment By Diet Therapy
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Author : William C.S. Cho
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-07-08
Cancer Chemoprevention And Treatment By Diet Therapy written by William C.S. Cho and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-08 with Medical categories.
Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Throughout the past few years, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer.