Cancer Complexity Computation
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Cancer Complexity Computation
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Author : Igor Balaz
language : en
Publisher: Springer Nature
Release Date : 2022-08-11
Cancer Complexity Computation written by Igor Balaz and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-11 with Technology & Engineering categories.
This book presents unique compendium of groundbreaking ideas where scientists from many different backgrounds are united in their interest in interdisciplinary approaches towards origins and development of cancers, innovative ways of searching for cancer treatment and the role of cancer in the evolution. Chapters give an unequivocal slice of all areas that relate to a quest for understanding cancer and its origin as many-fold nonlinear system, complexity of the cancer developments, a search for cancer treatment using artificial intelligence and evolutionary optimisation, novel modelling techniques, molecular origin of cancer, the role of cancer in evolution of species, interpretation of cancer in terms of artificial life and artificial immune systems, swarm intelligence, cellular automata, computational systems biology, genetic networks, cellular computing, validation through in vitro/vivo tumour models and tumour on chip devices. The book is an inspiring blend of theoretical and experimental results, concepts and paradigms. Distinctive features The book advances widely popular topics of cancer origin, treatment and understanding of its progress The book is comprised of unique chapters written by world top experts in theoretical and applied oncology, complexity theory, mathematics, computer science. The book illustrates attractive examples of mathematical and computer models and experimental setups.
Computational Methods For Understanding Complexity The Use Of Formal Methods In Biology
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Author : David A. Rosenblueth,
language : en
Publisher: Frontiers Media SA
Release Date : 2016-11-21
Computational Methods For Understanding Complexity The Use Of Formal Methods In Biology written by David A. Rosenblueth, and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with categories.
The complexity of living organisms surpasses our unaided habilities of analysis. Hence, computational and mathematical methods are necessary for increasing our understanding of biological systems. At the same time, there has been a phenomenal recent progress allowing the application of novel formal methods to new domains. This progress has spurred a conspicuous optimism in computational biology. This optimism, in turn, has promoted a rapid increase in collaboration between specialists of biology with specialists of computer science. Through sheer complexity, however, many important biological problems are at present intractable, and it is not clear whether we will ever be able to solve such problems. We are in the process of learning what kind of model and what kind of analysis and synthesis techniques to use for a particular problem. Some existing formalisms have been readily used in biological problems, others have been adapted to biological needs, and still others have been especially developed for biological systems. This Research Topic has examples of cases (1) employing existing methods, (2) adapting methods to biology, and (3) developing new methods. We can also see discrete and Boolean models, and the use of both simulators and model checkers. Synthesis is exemplified by manual and by machine-learning methods. We hope that the articles collected in this Research Topic will stimulate new research.
Computational Systems Biology Of Cancer
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Author : Emmanuel Barillot
language : en
Publisher: CRC Press
Release Date : 2012-08-25
Computational Systems Biology Of Cancer written by Emmanuel Barillot and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-25 with Science categories.
The future of cancer research and the development of new therapeutic strategies rely on our ability to convert biological and clinical questions into mathematical models—integrating our knowledge of tumour progression mechanisms with the tsunami of information brought by high-throughput technologies such as microarrays and next-generation sequencing. Offering promising insights on how to defeat cancer, the emerging field of systems biology captures the complexity of biological phenomena using mathematical and computational tools. Novel Approaches to Fighting Cancer Drawn from the authors’ decade-long work in the cancer computational systems biology laboratory at Institut Curie (Paris, France), Computational Systems Biology of Cancer explains how to apply computational systems biology approaches to cancer research. The authors provide proven techniques and tools for cancer bioinformatics and systems biology research. Effectively Use Algorithmic Methods and Bioinformatics Tools in Real Biological Applications Suitable for readers in both the computational and life sciences, this self-contained guide assumes very limited background in biology, mathematics, and computer science. It explores how computational systems biology can help fight cancer in three essential aspects: Categorising tumours Finding new targets Designing improved and tailored therapeutic strategies Each chapter introduces a problem, presents applicable concepts and state-of-the-art methods, describes existing tools, illustrates applications using real cases, lists publically available data and software, and includes references to further reading. Some chapters also contain exercises. Figures from the text and scripts/data for reproducing a breast cancer data analysis are available at www.cancer-systems-biology.net.
Computational Systems Bioinformatics
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Author : Xiaobo Zhou
language : en
Publisher: World Scientific
Release Date : 2008
Computational Systems Bioinformatics written by Xiaobo Zhou and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.
Computational systems biology is a new and rapidly developing field of research, concerned with understanding the structure and processes of biological systems at the molecular, cellular, tissue, and organ levels through computational modeling as well as novel information theoretic data and image analysis methods. By focusing on either information processing of biological data or on modeling physical and chemical processes of biosystems, and in combination with the recent breakthrough in deciphering the human genome, computational systems biology is guaranteed to play a central role in disease prediction and preventive medicine, gene technology and pharmaceuticals, and other biotechnology fields. This book begins by introducing the basic mathematical, statistical, and data mining principles of computational systems biology, and then presents bioinformatics technology in microarray and sequence analysis step-by-step. Offering an insightful look into the effectiveness of the systems approach in computational biology, it focuses on recurrent themes in bioinformatics, biomedical applications, and future directions for research.
Research In Computational Molecular Biology
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Author : Teresa M. Przytycka
language : en
Publisher: Springer
Release Date : 2015-03-25
Research In Computational Molecular Biology written by Teresa M. Przytycka and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-25 with Computers categories.
This book constitutes the refereed proceedings of the 19th Annual International Conference on Research in Computational Molecular Biology, RECOMB 2015, held in Warsaw, Poland, in April 2015. The 36 extended abstracts were carefully reviewed and selected from 170 submissions. They report on original research in all areas of computational molecular biology and bioinformatics.
Computational Systems Biology
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Author : Andres Kriete
language : en
Publisher: Academic Press
Release Date : 2013-11-26
Computational Systems Biology written by Andres Kriete and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-26 with Science categories.
This comprehensively revised second edition of Computational Systems Biology discusses the experimental and theoretical foundations of the function of biological systems at the molecular, cellular or organismal level over temporal and spatial scales, as systems biology advances to provide clinical solutions to complex medical problems. In particular the work focuses on the engineering of biological systems and network modeling. - Logical information flow aids understanding of basic building blocks of life through disease phenotypes - Evolved principles gives insight into underlying organizational principles of biological organizations, and systems processes, governing functions such as adaptation or response patterns - Coverage of technical tools and systems helps researchers to understand and resolve specific systems biology problems using advanced computation - Multi-scale modeling on disparate scales aids researchers understanding of dependencies and constraints of spatio-temporal relationships fundamental to biological organization and function.
Handbook Of Computational Statistics
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Author : James E. Gentle
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-06
Handbook Of Computational Statistics written by James E. Gentle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-06 with Computers categories.
The Handbook of Computational Statistics - Concepts and Methods (second edition) is a revision of the first edition published in 2004, and contains additional comments and updated information on the existing chapters, as well as three new chapters addressing recent work in the field of computational statistics. This new edition is divided into 4 parts in the same way as the first edition. It begins with "How Computational Statistics became the backbone of modern data science" (Ch.1): an overview of the field of Computational Statistics, how it emerged as a separate discipline, and how its own development mirrored that of hardware and software, including a discussion of current active research. The second part (Chs. 2 - 15) presents several topics in the supporting field of statistical computing. Emphasis is placed on the need for fast and accurate numerical algorithms, and some of the basic methodologies for transformation, database handling, high-dimensional data and graphics treatment are discussed. The third part (Chs. 16 - 33) focuses on statistical methodology. Special attention is given to smoothing, iterative procedures, simulation and visualization of multivariate data. Lastly, a set of selected applications (Chs. 34 - 38) like Bioinformatics, Medical Imaging, Finance, Econometrics and Network Intrusion Detection highlight the usefulness of computational statistics in real-world applications.
Computational Methods For Precision Oncology
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Author : Alessandro Laganà
language : en
Publisher: Springer Nature
Release Date : 2022-03-01
Computational Methods For Precision Oncology written by Alessandro Laganà and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-01 with Medical categories.
Precision medicine holds great promise for the treatment of cancer and represents a unique opportunity for accelerated development and application of novel and repurposed therapeutic approaches. Current studies and clinical trials demonstrate the benefits of genomic profiling for patients whose cancer is driven by specific, targetable alterations. However, precision oncologists continue to be challenged by the widespread heterogeneity of cancer genomes and drug responses in designing personalized treatments. Chapters provide a comprehensive overview of the computational approaches, methods, and tools that enable precision oncology, as well as related biological concepts. Covered topics include genome sequencing, the architecture of a precision oncology workflow, and introduces cutting-edge research topics in the field of precision oncology. This book is intended for computational biologists, bioinformaticians, biostatisticians and computational pathologists working in precision oncology and related fields, including cancer genomics, systems biology, and immuno-oncology.
Computational Immunology
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Author : Shyamasree Ghosh
language : en
Publisher: CRC Press
Release Date : 2019-10-14
Computational Immunology written by Shyamasree Ghosh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-14 with Medical categories.
The immune system is highly complex system with large number of macromolecules, signaling pathways, protein-protein interactions, and gene expressions. Studies from genomics, transcriptomics, metabolomics are generating huge high throughput data that needs to be analyzed for understanding the Immune system in Health and Disease. Computational approaches arehelping in understanding the study of complex biology of immunology and thereby enabling design of therapeutic strategies in diseases like infectious diseases, immunodeficiency, allergic, hypersensitive, autoimmune disorders and diseases like Cancer, HIV etc. Computational Immunology: Basics highlights the basics of the immune system and function in health and disease. This book offers comprehensive coverage of the most essential topics, including Overview of Immunology and computational Immunology Immune organs and cells, antigen, antibody, B, cell, T cell Antigen Processing and presentation Diseases due to abnormalities of the immune system Cancer Biology Shyamasree Ghosh (MSc, PhD, PGDHE, PGDBI), is currently working in the School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, DAE, Govt of India, graduated from the prestigious Presidency College Kolkata in 1998. She was awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.
Advances In Bioinformatics And Computational Biology
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Author : Nicole M. Scherer
language : en
Publisher: Springer Nature
Release Date : 2022-12-15
Advances In Bioinformatics And Computational Biology written by Nicole M. Scherer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-15 with Science categories.
This book constitutes the proceedings of the 15th Brazilian Symposium on Bioinformatics on Advances in Bioinformatics and Computational Biology, BSB 2022, which took place in Buzios, Brazil, in September 2022. The 10 full papers and 7 short papers presented in this volume were carefully reviewed and selected from 23 submissions. The papers focus on bioinformatics, computational biology, Biological Databases, Biological Networks, Cheminformatics, Evolutionary Genomics, Computational Proteomics, Systems Biology, Drug Design, Genomics, Machine Learning applications in Bioinformatics, Metagenomics, Molecular Docking and Modeling, Molecular Evolution and Phylogenetics, Protein Structure and Modeling, Proteomics, Transcriptomics, Single-Cell Analysis, Workflows in Bioinformatics.