Cancer Models
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Cancer Models
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Author : Michael Breitenbach
language : en
Publisher: Frontiers Media SA
Release Date : 2019-02-05
Cancer Models written by Michael Breitenbach and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-05 with categories.
Cancer research, like research on other diseases, highly depends on representative and reliable model systems. In the Research Topic “Cancer Models”, we collected original papers and review articles addressing the topic of tumor modeling from molecular biology, biochemistry, microorganisms, cells and organoids, fishes, animals and xenografts, up to computational cancer models and patient data analysis. This representative eBook describes that there is not a single molecular defined tumor but rather a heterogenic and highly variable complex of different individual diseases. This is what makes research on cancer so difficult, expensive, and explains the broad number of models needed for research. Our authors describe new next-generation sequencing-based methods to analyze complex patterns of chromosomal aberrations in order to understand the molecular biology of tumorigenesis as well as the role of cellular senescence and dormancy in the aetiology of tumor formation and development of therapy resistance of tumors. The current developments on 3D cultures are thoroughly reviewed, as these models help to overcome the current limitations of cell cultures and allow a more accurate mimicry of the native cancer tissue, including cellular heterogeneity and restore specific biochemical and morphological. Reviews about tumor models in zebrafish, different transgenic mouse strains and pigs conclude the book. In the final two chapters of this volume, the authors discuss the theoretical and mathematical models developed in cancer research.
Humanized Large Animal Cancer Models Accelerating Time And Effectiveness Of Clinical Trials
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Author : Kyle M. Schachtschneider
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-23
Humanized Large Animal Cancer Models Accelerating Time And Effectiveness Of Clinical Trials written by Kyle M. Schachtschneider and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-23 with categories.
This eBook provides futuristic perspectives with respect to the emerging requirements of large animal cancer models to address unmet clinical needs. As the vast majority of drugs tested in small animal cancer models fail in human clinical trials, there is a need for large animal models to translate results obtained in small animal models to human clinical practice.
Tumor Models In Cancer Research
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Author : Beverly A. Teicher
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-01
Tumor Models In Cancer Research written by Beverly A. Teicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Medical categories.
The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.
In Vitro Models For Cancer Research
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Author :
language : en
Publisher:
Release Date : 1985
In Vitro Models For Cancer Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Cancer cells categories.
Nutritional Oncology
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Author : George L. Blackburn
language : en
Publisher: Elsevier
Release Date : 2011-05-02
Nutritional Oncology written by George L. Blackburn and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-02 with Medical categories.
Nutritional oncology is an increasingly active interdisciplinary field where cancer is investigated as both a systemic and local disease originating with the changes in the genome and progressing through a multi-step process which may be influenced at many points in its natural history by nutritional factors that could impact the prevention of cancer, the quality of life of cancer patients, and the risk of cancer recurrence in the rapidly increasing population of cancer survivors.Since the first edition of this book was published in 1999, the idea that there is a single gene pathway or single drug will provide a cure for cancer has given way to the general view that dietary/environmental factors impact the progression of genetic and cellular changes in common forms of cancer. This broad concept can now be investigated within a basic and clinical research context for specific types of cancer. This book attempts to cover the current available knowledge in this new field of nutritional oncology written by invited experts. This book attempts to provide not only the theoretical and research basis for nutritional oncology, but will offer the medical oncologist and other members of multidisciplinary groups treating cancer patients practical information on nutrition assessment and nutritional regimens, including micronutrient and phytochemical supplementation. The editors hope that this volume will stimulate increased research, education and patient application of the principles of nutritional oncology.NEW TO THIS EDITION:* Covers hot new topics of nutrigenomics and nutrigenetics in cancer cell growth * Includes new chapters on metabolic networks in cancer cell growth, nutrigenetics and nutrigenomics* Presents substantially revised chapters on breast cancer and nutrition, prostate cancer and nutrition, and colon cancer and nutrition* Includes new illustrations throughout the text, especially in the breast cancer chapter* Includes integrated insights into the unanswered questions and clearly defined objectives of research in nutritional oncology * Offers practical guidelines for clinicians advising malnourished cancer patients and cancer survivors on diet, nutrition, and lifestyle * Provides information on the role of bioactive substances, dietary supplements, phytochemicals and botanicals in cancer prevention and treatment
Models For Prostate Cancer
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Author : Gerald Patrick Murphy
language : en
Publisher:
Release Date : 1980
Models For Prostate Cancer written by Gerald Patrick Murphy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.
Cancer Of The Breast
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Author : William L. Donegan
language : en
Publisher: Elsevier Health Sciences
Release Date : 2002
Cancer Of The Breast written by William L. Donegan and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
"Very readable, comprehensive and up-to-date throughout... A well written, well documented, comprehensive text of breast cancer care" (Annals of Surgery, review of previous edition). This trusted resource offers in-depth coverage of all aspects of breast cancer, from epidemiology and pathology through surgical and non-surgical management to psychological and legal issues. The meticulously updated and revised 5th Edition provides cutting-edge information on genetics, screening, mammography and sonography, lymphatic mapping and sentinel node biopsy, in situ carcinoma and early invasive carcinoma, biologic response modifiers, reconstruction, and much more!
Prostate Cancer
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Author : Peter R. Carroll
language : en
Publisher: B.C. Decker
Release Date : 2002
Prostate Cancer written by Peter R. Carroll and has been published by B.C. Decker this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
This volume offers an overview of prostate cancer. Topics covered include genetics, anatomy, detection and treatment. Numerous illustrations, photographs and radiographs show tumours as they manifest
Cancer Research
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Author :
language : en
Publisher:
Release Date : 2009-12
Cancer Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12 with Cancer categories.
Cancer And Inflammation
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2004-03-05
Cancer And Inflammation written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-03-05 with Medical categories.
Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach Immunoinformatics: bioinformatic strategies for better understanding of immune function Chair: Hans-Georg Rammensee