Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics
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Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics
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Author : Laura Cipolla
language : en
Publisher: World Scientific
Release Date : 2015-07-23
Carbohydrate Chemistry State Of The Art And Challenges For Drug Development An Overview On Structure Biological Roles Synthetic Methods And Application As Therapeutics written by Laura Cipolla and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-23 with Science categories.
The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.
Drug Discovery And Development
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Author : Vishwanath Gaitonde
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-11
Drug Discovery And Development written by Vishwanath Gaitonde and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-11 with Medical categories.
The process of drug discovery and development is a complex multistage logistics project spanned over 10-15 years with an average budget exceeding 1 billion USD. Starting with target identification and synthesizing anywhere between 10k to 15k synthetic compounds to potentially obtain the final drug that reaches the market involves a complicated maze with multiple inter- and intra-operative fields. Topics described in this book emphasize the progresses in computational applications, pharmacokinetics advances, and molecular modeling developments. In addition the book also contains special topics describing target deorphaning in Mycobacterium tuberculosis, therapy treatment of some rare diseases, and developments in the pediatric drug discovery process.
Coupling And Decoupling Of Diverse Molecular Units In Glycosciences
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Author : Zbigniew J. Witczak
language : en
Publisher: Springer
Release Date : 2017-11-20
Coupling And Decoupling Of Diverse Molecular Units In Glycosciences written by Zbigniew J. Witczak and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-20 with Science categories.
This unique book covers the latest developments in coupling and decoupling of biomolecules containing functionalized carbohydrate components, being one of the first collections in this important area of applied medicinal chemistry. Connecting molecules, often referred as bio-conjugation, has become one of the most often performed procedures in modern medicinal chemistry. Sometimes, when the connected molecules are not useful anymore, they must be disconnected. The molecules that must be connected (coupled) may belong to both small and large molecules and include such constructs as glycoproteins, glycopeptides and glycans. In this work, more than 15 experts address a comprehensive range of potential and current uses of in vitro and in vivo bio-conjugation methodologies, leading to a variety of glycoconjugates. The analytical aspects of bio-conjugation are also here discussed. Medicinal and organic chemists from graduate level onwards will understand the appeal of this important book.
Asymmetric Synthesis Of 3 3 Disubstituted Oxindoles
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Author : Renato Dalpozzo
language : en
Publisher: World Scientific
Release Date : 2019-09-11
Asymmetric Synthesis Of 3 3 Disubstituted Oxindoles written by Renato Dalpozzo and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-11 with Science categories.
Indole derivatives are the most common heterocycle compounds present in nature, for this reason, they have been referred to as 'privileged structures'. In fact, many approved drugs — and natural products — belong to this family. Among indole derivatives, oxindoles have a structural complexity, which have stimulated generations of synthetic chemists to design strategies for assembling these structures, and their enantioselective synthesis is still growing.This book proposes to describe the known enantioselective syntheses of oxindole derivatives. It is divided in six chapters each referring to a specific class of asymmetric oxindole derivatives. After the introduction, Chapter 2 describes all-carbon spirooxindoles; Chapter 3, open chain 3,3-dialkyloxindoles; Chapter 4, 3-substituted-3-aminooxindoles; Chapter 5, 3-substituted-3-hydroxyoxindoles; Chapter 6, 3-hetero-3-substituted oxindoles. It will be a useful tool for synthetic chemists, who assemble total synthesis of natural products, as well as for drug discovery chemists either in academic or in industry R&S laboratories.
Carbohydrates In Chemistry And Biology
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Author : Vinod Kumar Tiwari
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2025-04-21
Carbohydrates In Chemistry And Biology written by Vinod Kumar Tiwari and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-04-21 with Science categories.
Carbohydrates in Chemistry and Biology provides detailed information about the green synthesis, biological importance and catalytic applications of carbohydrate derivatives. It covers various topics including carbohydrate decorated compounds, bioconjugation, carbohydrate functionalized heterocycles, carbohydrate-spiro-heterocycles, heterocycles from carbohydrate precursors and natural sources of bioactive carbohydrates.
Bulletin Of The Atomic Scientists
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Author :
language : en
Publisher:
Release Date : 1972-10
Bulletin Of The Atomic Scientists written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1972-10 with categories.
The Bulletin of the Atomic Scientists is the premier public resource on scientific and technological developments that impact global security. Founded by Manhattan Project Scientists, the Bulletin's iconic "Doomsday Clock" stimulates solutions for a safer world.
Metal Organic Frameworks For Biomedical Applications
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Author : Masoud Mozafari
language : en
Publisher: Woodhead Publishing
Release Date : 2020-03-03
Metal Organic Frameworks For Biomedical Applications written by Masoud Mozafari and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-03 with Technology & Engineering categories.
Metal-Organic Frameworks for Biomedical Applications is a comprehensive, authoritative reference that offers a substantial and complete treatment of published results that have yet to be critically reviewed. It offers a summary of current research and provides in-depth understanding of the role of metal-organic frameworks in biomedical engineering. The title consists of twenty-two chapters presented by leading international researchers in the field. Chapters are arranged by target-application in biomedical engineering, allowing medical and pharmaceutic specialists to translate current materials and engineering science on metal-organic frameworks into their work.
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2003
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Bulletin Of The Atomic Scientists
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Author :
language : en
Publisher:
Release Date : 1972-12
Bulletin Of The Atomic Scientists written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1972-12 with categories.
The Bulletin of the Atomic Scientists is the premier public resource on scientific and technological developments that impact global security. Founded by Manhattan Project Scientists, the Bulletin's iconic "Doomsday Clock" stimulates solutions for a safer world.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1994
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medicine categories.