Carbohydrate Protein Interactions
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Carbohydrate Protein Interactions
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Author : D. Wade Abbott
language : en
Publisher: Springer Nature
Release Date : 2023-05-06
Carbohydrate Protein Interactions written by D. Wade Abbott and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-06 with Science categories.
This second edition provides new and updated tools for studying protein-carbohydrate interactions ranging from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes detailing methods for screening and quantifying CAZyme activity, investigating the interactions between proteins, carbohydrate ligands, methods for the visualization of carbohydrates, protein-carbohydrate complexes, structural and “omic” approaches for studying systems of CAZymes. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Carbohydrate- Protein Interactions: Methods and Protocols, Second Edition aims to be comprehensive guide for researchers in the field.
Carbohydrate Protein Interaction
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Author : Adrienne E. Clarke
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Carbohydrate Protein Interaction written by Adrienne E. Clarke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Carbohydrate as the primary product of photosynthesis has a vital role in the maintenance of life on this planet. Until relatively recently, interest in complex carbohydrates focussed on their structural role in the extracellular matrix/ cell wall of animal, plant, and microbial cells and on their role as energy sources (e.g., starch and glycogen) and struc tural components (e.g., cellulose) in natural products. There was, however, indirect evidence that carbohydrates could play an informational role; this evidence was from the find ing last century that plant lectins caused specific agglutina tion of certain animal cells and, more recently, that the agglutination was mediated by interactions between the plant lectin and cell surface carbohydrates. It is now clear that endogenous carbohydrate binding proteins are important in cell-cell recognition phenomena in animal systems. Recently, impressive evidence has been presented that complex oligosaccharides, derived from cell walls, are also important in plant recognition events, for example in signalling the defence mechanisms of a plant to respond to attack by insects and microbial pathogens.
Development Of Computational Methods To Characterize Carbohydrate Protein Interactions
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Author : Amika Sood
language : en
Publisher:
Release Date : 2016
Development Of Computational Methods To Characterize Carbohydrate Protein Interactions written by Amika Sood and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Specific carbohydrate-protein interactions are crucial in numerous physiological processes, disruption of which has been implicated in many different diseases like cancer. This provides researchers an opportunity to utilize carbohydrates as biomarkers and targets for therapeutics for such diseases. There has been a tremendous surge in the research being conducted towards the development of techniques to analyze carbohydrates and their specificity and affinity for different proteins. However, owing to their complex three-dimensional structure, stereochemistry, low binding affinities and broad specificity, carbohydrates have proven to be challenging to study. Therefore, new techniques and improvements in the existing methodologies are required. Here, we show that the incorporation of experimental data into molecular modeling can be used as a powerful combination to gain an understanding of the structural features of proteins and carbohydrates leading to the specificity in their interactions. Firstly, hydroxyl radical protein footprinting (HRPF) was used to establish a relationship between the oxidation of amino acids exposed on the surface of a protein and their solvent accessible surface area (SASA). Oxidation, as well as SASA, are both directly proportional to the exposure of an amino acid to the solvent. This relationship was used to estimate SASA of residues of a protein in solution, which was then successfully utilized as a score to quantify the quality of models generated through a molecular dynamics (MD) simulation and homology modeling. This relationship can also be used to study protein- carbohydrate interactions, which remains to be tested. Secondly, the functional groups of a monosaccharide essential for forming protein-carbohydrate interactions were identified by using co-crystal structures and per-atom binding energy analysis, which shows that not all chemically-equivalent functional groups are equally significant for binding. Lastly, the 3D structure of a group of monosaccharides was analyzed and it was observed that two monosaccharides can possess structural similarities depending on their alignment, which can be used to explain cross-reactivity between a protein and more than one carbohydrate.
Carbohydrate Protein Interactions
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Author : Aharon Katzir-Katchalsky. Center of the Weizmann Institute of Science
language : en
Publisher:
Release Date :
Carbohydrate Protein Interactions written by Aharon Katzir-Katchalsky. Center of the Weizmann Institute of Science and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Protein Carbohydrate Interactions
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Author : D. Wade Abbott
language : en
Publisher: Humana Press
Release Date : 2017-05-02
Protein Carbohydrate Interactions written by D. Wade Abbott and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-02 with Science categories.
This volume is a wide-ranging tool for studying protein-carbohydrate interactions that extend from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes: Part I describes methods for screening and quantifying CAZyme activity; Part II contains methods for investigating the interactions between proteins and carbohydrate ligands; Part III discusses methods for the visualization of carbohydrates and protein-carbohydrate complexes; and Part IV focuses on structural and “omic” approaches for studying systems of CAZymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein-Carbohydrate Interactions: Methods and Protocols is a valuable resource to the glycomics research community. In this continuously advancing field, the methods in this book highlight the biology of glycomics, thus driving biotechnological innovation and solutions for human health and sustainable resources within the emerging green community.
Carbohydrate Protein Interactions
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Author : Sai Kumar Ramadugu
language : en
Publisher:
Release Date : 2013
Carbohydrate Protein Interactions written by Sai Kumar Ramadugu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Molecular dynamics categories.
Ch Pi Interactions Play A Central Role In Protein Recognition Of Carbohydrates
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Author : Roger Christopher Diehl
language : en
Publisher:
Release Date : 2021
Ch Pi Interactions Play A Central Role In Protein Recognition Of Carbohydrates written by Roger Christopher Diehl and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
Carbohydrate-protein interactions play a central role in biology, but knowledge of the forces underlying them is limited. Carbohydrates are generally hydrophilic and therefore present unique challenges in their recognition. One underappreciated force involved in carbohydrate-protein interactions is the CH-[pi] interaction, an attractive interaction between the aliphatic protons of a carbohydrate and the [pi] system of an aromatic ring. In this thesis, I examine the fundamental nature, strength, and biological significance of this interaction, largely in the context of a family of carbohydrate-binding proteins known as galectins. In Chapter 1, I review previous knowledge of the forces underlying carbohydrate-binding proteins and the forces they utilize to bind their ligands. In particular, I focus on CH-[pi] interactions and galectins. In Chapter 2, I examine the forces that contribute to CH-[pi] interactions in the context of carbohydrates and aromatic compounds in aqueous solution. I find the CH-[pi] interaction to be electronic in nature, and demonstrate its selectivity between different carbohydrates. In Chapter 3, I determine the contribution of the CH-[pi] interaction to the ligand binding of galectin-3, a human carbohydrate-binding protein of medical significance. The data demonstrate that the CH-[pi] interaction accounts for a majority of the binding energy. In Chapter 4, I explore the biological implications of the CH-[pi] interaction in galectin-3. I demonstrate that the CH-[pi] interaction is critical for the biological activities of galectin-3. In Chapter 5, I propose several directions future researchers could take to extend this work. For three of four directions, I present the progress I have made during my studies. The work contained within this thesis demonstrates that CH-[pi] interactions play a central role in protein-carbohydrate interactions at both a molecular level and a biological level. Understanding the CH-[pi] interaction is key to explaining and predicting the activity of carbohydrate-binding proteins.
Carbohydrate Protein Interactions In The Extracellular Matrix
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Author : Biochemical Society
language : en
Publisher:
Release Date :
Carbohydrate Protein Interactions In The Extracellular Matrix written by Biochemical Society and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Database Development And Analysis Of Carbohydrate Protein Interactions
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Author : Sonu Kumar
language : en
Publisher:
Release Date : 2012
Database Development And Analysis Of Carbohydrate Protein Interactions written by Sonu Kumar and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Glycan Based Cellular Communication
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Author : Peng George Wang
language : en
Publisher:
Release Date : 2020
Glycan Based Cellular Communication written by Peng George Wang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Carbohydrates categories.