Protein Carbohydrate Interactions
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Carbohydrate Protein Interactions
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Author : D. Wade Abbott
language : en
Publisher: Springer Nature
Release Date : 2023-05-06
Carbohydrate Protein Interactions written by D. Wade Abbott and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-06 with Science categories.
This second edition provides new and updated tools for studying protein-carbohydrate interactions ranging from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes detailing methods for screening and quantifying CAZyme activity, investigating the interactions between proteins, carbohydrate ligands, methods for the visualization of carbohydrates, protein-carbohydrate complexes, structural and “omic” approaches for studying systems of CAZymes. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and methods, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Carbohydrate- Protein Interactions: Methods and Protocols, Second Edition aims to be comprehensive guide for researchers in the field.
Protein Carbohydrate Interactions
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Author : D. Wade Abbott
language : en
Publisher:
Release Date : 2017
Protein Carbohydrate Interactions written by D. Wade Abbott and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Carbohydrates categories.
"This volume is a wide-ranging tool for studying protein-carbohydrate interactions that extend from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes: Part I describes methods for screening and quantifying CAZyme activity; Part II contains methods for investigating the interactions between proteins and carbohydrate ligands; Part III discusses methods for the visualization of carbohydrates and protein-carbohydrate complexes; and Part IV focuses on structural and "omic" approaches for studying systems of CAZymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein-Carbohydrate Interactions: Methods and Protocols is a valuable resource to the glycomics research community. In this continuously advancing field, the methods in this book highlight the biology of glycomics, thus driving biotechnological innovation and solutions for human health and sustainable resources within the emerging green community. ."--Prové de l'editor.
Protein Carbohydrate Interactions In Infectious Diseases
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Author : Carole A Bewley
language : en
Publisher: Royal Society of Chemistry
Release Date : 2007-10-31
Protein Carbohydrate Interactions In Infectious Diseases written by Carole A Bewley and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-31 with Science categories.
Protein-carbohydrate interactions is an exciting area of research with huge potential for development and exploration. These interactions are both widespread and diverse in biological processes and many play a crucial role in cellular recognition, attachment and adhesion. This is particularly true for host-pathogen interactions that lead to infectious diseases; as the surfaces of cells and pathogens display complex carbohydrate structures and carbohydrate binding proteins on their surface. Protein-Carbohydrate Interactions in Infectious Disease is part of the Biomolecular Science Series and provides a comprehensive overview of the subject, with contributions from leading experts in the field. Beginning with a general introduction, subsequent sections include: Atomic basis of protein-carbohydrate interactions, Structures and roles of Pseudomonas areuginosa lectins, Protein-carbohydrate interactions in enterobacterial infections, Retrocyclins: miniature lectins with potent antiviral activity, C-type lectin receptors that regulate pathogen recognition through the recognition of carbohydrates, Synthetic carbohydrate-based anti-malarial vaccines and glycobiology. With full colour throughout and an extensive bibliography this book is ideal for researchers interested in the area.
Protein Carbohydrate Interactions
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Author : Davina Noelle Moothoo
language : en
Publisher:
Release Date : 1998
Protein Carbohydrate Interactions written by Davina Noelle Moothoo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Protein Carbohydrate Interactions
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Author : D. Wade Abbott
language : en
Publisher: Humana Press
Release Date : 2017-05-02
Protein Carbohydrate Interactions written by D. Wade Abbott and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-02 with Science categories.
This volume is a wide-ranging tool for studying protein-carbohydrate interactions that extend from traditional biochemical methods to state-of-the-art techniques. This book focuses on four different research themes: Part I describes methods for screening and quantifying CAZyme activity; Part II contains methods for investigating the interactions between proteins and carbohydrate ligands; Part III discusses methods for the visualization of carbohydrates and protein-carbohydrate complexes; and Part IV focuses on structural and “omic” approaches for studying systems of CAZymes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Protein-Carbohydrate Interactions: Methods and Protocols is a valuable resource to the glycomics research community. In this continuously advancing field, the methods in this book highlight the biology of glycomics, thus driving biotechnological innovation and solutions for human health and sustainable resources within the emerging green community.
Carbohydrate Protein Interaction
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Author : Adrienne E. Clarke
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Carbohydrate Protein Interaction written by Adrienne E. Clarke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
Carbohydrate as the primary product of photosynthesis has a vital role in the maintenance of life on this planet. Until relatively recently, interest in complex carbohydrates focussed on their structural role in the extracellular matrix/ cell wall of animal, plant, and microbial cells and on their role as energy sources (e.g., starch and glycogen) and struc tural components (e.g., cellulose) in natural products. There was, however, indirect evidence that carbohydrates could play an informational role; this evidence was from the find ing last century that plant lectins caused specific agglutina tion of certain animal cells and, more recently, that the agglutination was mediated by interactions between the plant lectin and cell surface carbohydrates. It is now clear that endogenous carbohydrate binding proteins are important in cell-cell recognition phenomena in animal systems. Recently, impressive evidence has been presented that complex oligosaccharides, derived from cell walls, are also important in plant recognition events, for example in signalling the defence mechanisms of a plant to respond to attack by insects and microbial pathogens.
Chemical And Biological Approaches For The Investigation Of Protein Carbohydrate Interactions
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Author : Joseph L. Lundquist
language : en
Publisher:
Release Date : 2002
Chemical And Biological Approaches For The Investigation Of Protein Carbohydrate Interactions written by Joseph L. Lundquist and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Carbohydrates categories.
Non Lectin Type Protein Carbohydrate Interactions
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Author : Veer Sandeep Bhatt
language : en
Publisher:
Release Date : 2011
Non Lectin Type Protein Carbohydrate Interactions written by Veer Sandeep Bhatt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Abstract: Protein-carbohydrate interactions are critical in a multitude of life processes such as bioenergetics, inflammation, cell-cell recognition, cell differentiation, embryonic development, signal transduction and host-pathogen interactions. However, the events leading to protein-carbohydrate recognition and the modulation of protein activity by glycosylation are poorly understood at molecular level. The primary objective in this work is to enrich our understanding of protein-carbohydrate interactions at a molecular level using three model systems. The first system is that of hemoglobin. The modulation of oxygen affinity by various interactions at the quaternary level is first presented in an investigation of the high oxygen affinity Greyhound hemoglobin. This is followed by a structural investigation of bovine hemoglobin carrying different lengths and types of oligosaccharides. These investigations indicate that glycosylation can increase the intrinsic oxygen affinity of hemoglobin by modifying its quaternary structure. The second system is that of a carbohydrate processing enzyme, a uridine 5'-diphospho N-acetylgalactosamine 4-epimerase. An elaborate investigation of structure and activity of this enzyme reveals several novel details of substrate recognition that may have been overlooked previously. Notably, this investigation highlights the complexities of protein-carbohydrate recognition and provides evidence that carbohydrates by themselves may induce global changes in multi-domain proteins. It further indicates that non-polar interactions are also critical in mediating protein-carbohydrate interactions and should be given due consideration in applications such as carbohydrate-based drug discovery. Thirdly, a complex system comprising of a multi-protein machinery that regulates the size of a hetero-polysaccharide called O-antigen, is presented. This system is an essential part of lipopolysaccharide biosynthesis in Gram-negative bacteria. This investigation strongly suggests that a protein called Wzz serves as a trap for nascent oligosaccharide chains while interacting with another protein called Wzy that is responsible for polymerization of these nascent oligosaccharide chains to form the mature O-antigen. Protein X-ray crystallography and routine experimental methods of modern molecular biology such as gene cloning, expression, protein purification and characterization have been used as primary techniques in this work. In addition, computational analysis, especially to perform protein-ligand docking is also used to investigate the third system.
Dissecting The Thermodynamics Of Protein Carbohydrate Interactions
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Author : Steve Chai-Fu Ding
language : en
Publisher:
Release Date : 2005
Dissecting The Thermodynamics Of Protein Carbohydrate Interactions written by Steve Chai-Fu Ding and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Carbohydrates categories.
A Structural Characterization Of Protein Carbohydrate Interactions
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Author : David Forrest Thieker
language : en
Publisher:
Release Date : 2017
A Structural Characterization Of Protein Carbohydrate Interactions written by David Forrest Thieker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Although carbohydrates are most commonly associated with metabolism, these molecules are involved in a variety of other critical processes that range from cellular trafficking to transcriptional regulation. Alterations in carbohydrate sequence are linked to a host of diseases ranging from cancer to dementia, yet progress in structural glycobiology has been slow compared to that of proteins and DNA. The following work pushes the boundary of our understanding of carbohydrate interactions at the atomic level. First, a 3D adaptation of the Symbol Nomenclature for Glycans (SNFG) was developed as a cartoon representation for carbohydrates to improve the communication of complex structural features to both glycobiologists and non-specialists. Second, the prediction of protein-carbohydrate complexes was improved by including a scoring term within docking programs that accounts for the linkage between glycan residues. Third, the crystal structure of a silayltransferase is presented with a docked model for the sugar donor. Fourth, a significant binding preference was identified between an enzyme within the heparan sulfate biosynthetic pathway and downstream products, with implications for protein localization in vivo. Lastly, a study of the intra-molecular interactions of a glycoprotein suggests a regulatory mechanism in which glycosylation affects intrinsic protein dynamics. Collectively, these efforts contribute to our understanding of the glycan structure-function relationship and facilitate future efforts in glycobiology.