Carbohydrate Recognition In Cellular Function
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Carbohydrate Recognition In Cellular Function
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Author : Gregory R. Bock
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-30
Carbohydrate Recognition In Cellular Function written by Gregory R. Bock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-30 with Science categories.
Contributors to this volume explore the role of carbohydrates in communication between cells of multicellular organisms. Topics covered include the thermodynamics and spatial restrictions of oligosaccharide-protein interactions, the role of carbohydrates in recognition and as components of cell adhesion molecules, and abnormal glycosylation in several disease states.
Carbohydrate Recognition
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Author : Binghe Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-06
Carbohydrate Recognition written by Binghe Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-06 with Medical categories.
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Mammalian Carbohydrate Recognition Systems
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Author : Paul R. Crocker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Mammalian Carbohydrate Recognition Systems written by Paul R. Crocker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins. This book covers the structures and postulated functions for the major classes of mammalian carbohydrate binding proteins. These include intracellular lectins involved in diverse functions such as protein synthesis quality control, targetting of lysosomal enzymes and in the secretory pathway. In addition, several chapters are devoted to other major families of lectins that are found at the cell surface or in extracellular fluids which are involved in various recognition functions such as cell-cell interactions in inflammation and recognition of pathogen carbohydrates in host defence.
Mammalian Carbohydrate Recognition Systems
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Author : Paul R Crocker
language : en
Publisher:
Release Date : 2000-11-27
Mammalian Carbohydrate Recognition Systems written by Paul R Crocker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-11-27 with categories.
The Role Of Glycans In Immune Cell Functions
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Author : Jasmeen S. Merzaban
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-26
The Role Of Glycans In Immune Cell Functions written by Jasmeen S. Merzaban and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-26 with categories.
Glycans represent a major constituency of post-translational modifications that occur on most, if not all, proteins. Whether on mammalian or invertebrate cell surfaces, they exist as sugar chain moieties designed from the exquisite and coordinated activity of cell-specific glycosylation. Some of the more common glycan structures are linked to cell surface polypeptides via an asparagine (N)-linked residue or a serine/threonine (O)-linked residue, along with a notable contingent found linked to ceramides in the lipid bilayer known as glycosphingolipids. These glycans can associate with complementary glycan-binding proteins (GBP) or lectins to mediate and translate this carbohydrate recognition to cell function. In immunity, there is increasing evidence that precise immune cell glycans are recognized by corresponding GBPs in a cell-intrinsic or -extrinsic manner. Unique carbohydrate recognition domains within GBPs are comprised of precisely spaced amino acid functional groups that allow for selective engagement of a particular glycan target. This structure-function relationship is present in immune signaling pathways, whereby glycans and GBPs on the surface of immune cells (and non-immune cells) help control processes such as immune cell activation, recognition of pathogens, suppression and tissue-specific migration. The diversity of glycan structures and glycosylation among individual immune cell subsets is controlled by the expression of genes involved in glycan biosynthesis including glycosyltransferases, glycosidases, glycan-precursor biosynthetic enzymes and nucleotide-sugar transporters. These genes represent more than 3% of the human genome, and cell-specific expression of these genes dictates a cell’s glycan repertoire, ultimately influencing its molecular interactions with GBPs. Altogether, these emerging lines of investigation highlight the regulatory capacity of glycans in immune health and disease, which in turn, pave the way for novel diagnostic, prognostic, and therapeutic strategies.
Carbohydrate Based Drug Discovery 2 Volume Set
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Author : Chi-Huey Wong
language : en
Publisher: John Wiley & Sons
Release Date : 2003-10-17
Carbohydrate Based Drug Discovery 2 Volume Set written by Chi-Huey Wong and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-10-17 with Science categories.
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
Essentials Of Glycobiology
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Author : Ajit Varki
language : en
Publisher: CSHL Press
Release Date : 1999
Essentials Of Glycobiology written by Ajit Varki and has been published by CSHL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Glycoscience
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Author : Bertram O. Fraser-Reid
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-04-14
Glycoscience written by Bertram O. Fraser-Reid and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-14 with Science categories.
As a reflection of the quantum leap that has been made in the study of glycostructures, the first edition of this book has been completely revised and updated. The editors give up-to-date information on glycostructures, their chemistry and chemical biology in the form of a completely comprehensive survey. Glycostructures play highly diverse and crucial roles in a myriad of organisms and important systems in biology, physiology, medicine, bioengineering and technology. Only in recent years have the tools been developed to partly understand the highly complex functions and the chemistry behind them. While many facts remain undiscovered, this MRW has been contributed to by a large number of the world’s leading researchers in the field.
Recognition Of Carbohydrates In Biological Systems Part A General Procedures
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Author : Y. C. Lee
language : en
Publisher: Elsevier
Release Date : 2003-09-15
Recognition Of Carbohydrates In Biological Systems Part A General Procedures written by Y. C. Lee and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-15 with Science categories.
Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covers the wide area of methodology of carbohydrate recognition. This volume, Recognition of Carbohydrates in Biological Systems, Part A: General Procedures, and its companion, Volume 363, present state-of-the-art methodologies, as well as the most recent biological observations in this area. Covers the isolation/synthesis of substances used in studying interactions involving carbohydrates Discussed the methodology for measuring such interactions Biological roles for such interactions are also covered
Recognition Of Carbohydrates In Biological Systems Part B Specific Applications
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Author :
language : en
Publisher: Elsevier
Release Date : 2003-11-06
Recognition Of Carbohydrates In Biological Systems Part B Specific Applications written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-11-06 with Science categories.
Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covers the wide area of methodology of carbohydrate recognition. This volume, Recognition of Carbohydrates in Biological Systems, Part B: Specific Applications, and its companion, Volume 362, present state-of-the-art methodologies, as well as the most recent biological observations in this area. Covers carbohydrate-binding proteins Discusses glycoproteins and glycolipids Polysaccharides, enzymes and cells are also covered