Cardiac Drug Development Guide
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Cardiac Drug Development Guide
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Author : Michael K. Pugsley
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-06
Cardiac Drug Development Guide written by Michael K. Pugsley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-06 with Medical categories.
Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today.
Cardiovascular Drug Development
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Author : John Somberg
language : en
Publisher: CRC Press
Release Date : 1998-11-04
Cardiovascular Drug Development written by John Somberg and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-11-04 with Medical categories.
These multidisciplinary presentations provide information essential to devising effective drug protocols in cardiovascular drug development, facilitating the approval process. Guides researchers and developers through the government drug approval process, facilitating development, minimizing costs, and harmonizing international standards employed in the creation of vital new cardiovascular therapies! Cardiovascular Drug Development explores the delicate balance of efficacy and safety that cardiovascular therapy must achieve to gain regulatory approval discusses the search for surrogates and the need in some areas for natural history endpoints reviews optimum strategies for protocol design in the development of drugs to treat hypertension, cardiac arrhythmias, heart failure, coronary artery disease, and hypercholesterolemia and other lipid disorders compares and contrasts the varying standards of evidence for drug approval in the United States, Europe, and Asia and more! Cardiovascular Drug Development will prove to be a valuable asset for cardiologists, pharmacologists and pharmacists, regulatory affairs specialists, and directors of research and development for pharmaceutical companies.
Cardiac Safety Of Noncardiac Drugs
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Author : Joel Morganroth
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-10-10
Cardiac Safety Of Noncardiac Drugs written by Joel Morganroth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-10 with Medical categories.
Cardiac Safety of Noncardiac Drugs: Practical Guidelines for Clinical Research and Drug Development is designed to present the current preclinical, clinical, and regulatory principles to assess the cardiac safety of new drugs based primarily on their effects on the ECG. Practical guidance to define cardiac safety at all stages of clinical research and drug development are featured and discussed by internationally recognized experts with academic, industrial, and regulatory experience.
Integrated Cardiac Safety
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Author : J. Rick Turner
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-26
Integrated Cardiac Safety written by J. Rick Turner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-26 with Medical categories.
The serious nature of cardiovascular adverse drug reactions occurring in patients makes assessment of a drug's cardiac safety profile a high priority during both development and post-approval monitoring. Integrated Cardiac Safety provides necessary guidance and methodology for professionals assessing cardiac safety of drugs throughout all stages of the drug's life, from discovery and development through postmarketing research. This self-contained, reader-friendly text is valuable to professionals in the pharmaceutical, biotechnology, and CRO industries, pharmacologists, toxicologists, government officials, and students.
Human Genetics And Big Data To Guide Cardiovascular Drug Development
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Author : Arjen J. Cupido
language : en
Publisher:
Release Date : 2023
Human Genetics And Big Data To Guide Cardiovascular Drug Development written by Arjen J. Cupido and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Cardiac Drug Safety
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Author : Matthew J. Killeen
language : en
Publisher: World Scientific
Release Date : 2012
Cardiac Drug Safety written by Matthew J. Killeen and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
Ensuring the safety of new medical products remains a major challenge for the pharmaceutical industry. Cardiac safety, particularly drug-induced heart rhythm abnormalities, remains an important cause of pipeline attrition and has resulted in countless major product recalls or label changes. The risk of encountering this major adverse event continues to shape the drug development and regulatory landscape. Extensive research over the past decade has shed light on the root causes of arrhythmias that are triggered by medications and has helped drive, and optimize, drug safety testing. However, current cardiac safety platforms have several limitations and there remains a pressing unmet need to improve the predictive power of today's drug safety tests. Fundamental to addressing the problem of drug-induced arrhythmias, and to reducing the impact of this safety signal on drug development, is a complete understanding of how these events may arise, what cardiac safety tests are currently used, and what opportunities there are to enhance patient safety and reduce the risk of detecting cardiac toxicity in later stages of product commercialization. By introducing the reader to these core concepts, this book delivers key insight into the increasingly important and dynamic field of cardiac safety.
The Esc Handbook On Cardiovascular Pharmacotherapy
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Author : Juan Carlos Kaski
language : en
Publisher: European Society of Cardiology
Release Date : 2019-05-23
The Esc Handbook On Cardiovascular Pharmacotherapy written by Juan Carlos Kaski and has been published by European Society of Cardiology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-23 with Medical categories.
The ESC Handbook on Cardiovascular Pharmacotherapy, based on the most recent guidelines in cardiovascular pharmacology, and containing a comprehensive A-Z formulary of common and less commonly used cardiac drugs and drug groups, provides practical and accessible guidance on all areas of drugprescribing.Previously published as Drugs in Cardiology, this new edition has been developed by the ESC Working Group on Cardiovascular Pharmacology. Pharmacology is an integral aspect in almost all disciplines within cardiology and all cardiologists use cardiovascular drugs.Completely updated and aligned with the ESC Clinical Practice Guidelines for prescribing, this handbook is essential reading for consultants, registrars in training, general practitioners, specialist cardiac nurses and cardiovascular pharmacologists.
Frontiers In Cardiovascular Drug Discovery
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Author : Atta-ur-Rahman
language : en
Publisher: Bentham Science Publishers
Release Date : 2016-11-01
Frontiers In Cardiovascular Drug Discovery written by Atta-ur-Rahman and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-01 with Medical categories.
Frontiers in Cardiovascular Drug Discovery is an eBook series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The eBook series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. The third volume of the series covers the following topics: - P2Y12 receptor agonists -Heart failure pharmacotherapy -Vasopressin and the cardiovascular system -Cerebral small vessel disease -Complement blocking therapeutic strategies -New antiplatelet and anticoagulating agents for gastrointestinal treatments
Cardiotoxicity Of Non Cardiovascular Drugs
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Author : Giorgio Minotti
language : en
Publisher: Wiley
Release Date : 2010-05-24
Cardiotoxicity Of Non Cardiovascular Drugs written by Giorgio Minotti and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-24 with Science categories.
Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.
Cardiac Drugs
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Author : Kanu Chatterjee
language : en
Publisher: JAYPEE BROTHERS PUBLISHERS
Release Date : 2013-12-15
Cardiac Drugs written by Kanu Chatterjee and has been published by JAYPEE BROTHERS PUBLISHERS this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-15 with Medical categories.
Doody Rating : 3 stars : Cardiac drugs resource endows with the latest advances in cardiovascular pharmacology. Written by experts in cardiology from world renowned institutes, equipped with global view, signifying the best possible combination of clinical and research expertise in cardiovascular pharmacology. This is a comprehensive drug resource which provides up-to-date information on one of the most rapidly changing areas of medicine. Easy to follow, providing practical advice on how to manage cardiac diseases with a focus on hands-on therapeutic guidance for the clinicians. Text talks about all of the drug-groups useful in various indications like drugs for acute coronary syndromes, dyslipidemia, hypertension, pulmonary hypertension, angina, etc. along with data from clinical trials. This book is exhaustive coverage of newly evolving co-morbid conditions with chapters on metabolic syndrome and pregnancy. Future directions: Pharmacogenomics elaborates on gene interactions with cardiovascular drugs. The unique feature of this book is the detailed discussion on the guidelines of the American College of Cardiology/American Heart Association for the use of pharmacologic agents in various clinical conditions. It is enhanced with four colour illustrations and images, illustrating the key pharmacological and physiological actions. It is useful for cardiologist, pharmacologist, physicians, clinicians and specialist.
