Cardiotoxicity Of Non Cardiovascular Drugs

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Cardiotoxicity Of Non Cardiovascular Drugs

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Author : Giorgio Minotti
language : en
Publisher: John Wiley & Sons
Release Date : 2010-03-25

Cardiotoxicity Of Non Cardiovascular Drugs written by Giorgio Minotti and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-25 with Science categories.

Some drugs which are not aimed at treating heart disease have nevertheless been found to have profound effects on heart muscle. Cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals.In recent years a number of non-cardiac blockbuster drugs such as terfenadine have been withdrawn from major markets because of cardiotoxicity concerns, while other drugs have either been withdrawn prior to marketing or required labelling changes that significantly restricted their use. In Cardiotoxicity of Non-Cardiovascular Drugs international experts describe the molecular mechanisms and clinical read-outs of cardiac events induced by a broad variety of noncardiovascular drugs. Particular emphasis is paid to the preclinical screening of drug cardiotoxicity. Topics include: metabolic targets of cardiotoxicity regulatory aspects translating molecular mechanisms into clinical trials structure-activity relationships in arrhythmias by antihistamines and psychoactive drugs cardiovascular toxicity of antitumor drugs cardiovascular toxicities of non-steroidal anti-inflammatory drugs cardiovascular toxicities of antiretroviral therapies Cardiotoxicity of Non-Cardiovascular Drugs is an essential guide to this important area of drug development. It will find a place on the bookshelves of researchers, regulators and students in medicinal chemistry, drug development, pharmacology, pharmacy and cardiovascular disease.

Cardiotoxicity

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Author : Wenyong Tan
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-11-14

Cardiotoxicity written by Wenyong Tan and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-14 with Medical categories.

Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.

Cardiotoxicity Of Oncologic Treatments

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Author : Manuela Fiuza
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-28

Cardiotoxicity Of Oncologic Treatments written by Manuela Fiuza and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-28 with Medical categories.

The possibility of getting a cardiovascular disease or cancer increases with advancing age. At the same time, relevant improvements in cancer therapy have resulted in the improvement of quality of life and the increasement of the survival rate of such patients. As a result we have larger number of patients that experience the cardiac side effects of chemotherapy. The extent of cardiotoxicity is variable, depending on the type of drug used, combination with other drugs, prior mediastinal radiotherapy and the presence of cardiovascular risk factors or history of heart disease. Early detection of the patients proneness for developing cardiotoxicity is the key issue to decrease morbidity and mortality. It also facilitates more tailored therapeutic interventions. Therefore, the collaboration and interaction of cardiology and oncology may contribute to reducing the cardiovascular adverse effects and improving the results in the treatment of patients with cancer.

Holland Frei Cancer Medicine

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Author : Robert C. Bast, Jr.
language : en
Publisher: John Wiley & Sons
Release Date : 2017-03-10

Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-10 with Medical categories.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Cancer And The Heart

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Author : Michael S. Ewer
language : en
Publisher: PMPH-USA
Release Date : 2013

Cancer And The Heart written by Michael S. Ewer and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Drugs categories.

The book begins with the basic science behind the medical applications of the knowledge: cardiovascular biology, pathways, and their relationship to cancer treatment and principles of chemotherapy and immunotherapy. The second section consists of an overview and classification of anti-cancer drugs and a look at their cardiotoxicity. The third section looks at cardiac imaging in the cancer patient, including cardiac ultrasound, Doppler imaging, nuclear imaging, magnetic resonance imaging, and computed tomography in the cancer patient. In section four, management of cardiac disease in the cancer patient is discussed, including cardiac rhythm disturbances and heart failure. Cardiac emergencies and interventions are described as is preoperative assessment of the cancer patient for non- cardiovascular surgery. The final section includes a range of topics such as the pericardium, cardiovascular effects of endocrine treatments, primary cardiac tumors and malignancies of the myocardium and pericardium. Cardiac monitoring during clinical trials and pulmonary concerns are also addressed, as are psychosocial, social, economic, and legal issues of the cancer patient with heart disease.

Cardiovascular Safety In Drug Development And Therapeutic Use

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Author : J. Rick Turner
language : en
Publisher: Springer
Release Date : 2016-07-28

Cardiovascular Safety In Drug Development And Therapeutic Use written by J. Rick Turner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-28 with Medical categories.

At a time when the field of cardiac safety is going through important changes, this unique book provides the rationale for, and cutting-edge explanations of, new regulatory landscapes that will likely govern cardiac safety assessments globally for the foreseeable future. Exposure-response modeling is already being accepted by regulatory agencies in lieu of the traditional Thorough QT/QTc Study, and the Comprehensive in vitro Proarrhythmia Assay initiative is well under way. Developments in the field of cardiovascular safety are also described and discussed in the book. These include the search for more efficient ways to exonerate new drugs for type 2 diabetes from an unacceptable cardiovascular liability, how best to address off-target blood pressure increases induced by noncardiovascular drugs, and the continued evolution of the discipline of Cardio-oncology. “a resource that will likely serve as a standard for years to come” - Dr Jonathan Seltzer Therapeutic Innovation & Regulatory Science, 2017;51(2):180 “I have no hesitation in recommending this book as a valuable reference source” - Dr Rashmi Shah Journal for Clinical Studies, 2017;9(1):62-63

Heart And Toxins

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Author : Dr. Meenakshisundaram Sundaram Ramachandran
language : en
Publisher: Elsevier
Release Date : 2014-08-12

Heart And Toxins written by Dr. Meenakshisundaram Sundaram Ramachandran and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-12 with Science categories.

The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity. Structured to bring together exploration into the epidemiology, molecular mechanism, pathogenesis, environmental factors and management in cardiovascular toxins” Included various topics on cardiovascular toxins such as plant, chemical, animal, nanomaterial and marine biology induced cardiac damage – which are new ideas discussed in detail Comprehensive chapters on the cardiovascular toxicity from drugs, radiotherapy and radiological imaging Enables you to manage multiple clinical cases of cardiovascular toxicity Outlined conclusions at the end of each chapter providing “key learning points” to help you organize the chapter’s details without losing insight

Cardiac Drugs

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Author : Kanu Chatterjee
language : en
Publisher: JAYPEE BROTHERS PUBLISHERS
Release Date : 2013-12-15

Cardiac Drugs written by Kanu Chatterjee and has been published by JAYPEE BROTHERS PUBLISHERS this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-15 with Medical categories.

Doody Rating : 3 stars : Cardiac drugs resource endows with the latest advances in cardiovascular pharmacology. Written by experts in cardiology from world renowned institutes, equipped with global view, signifying the best possible combination of clinical and research expertise in cardiovascular pharmacology. This is a comprehensive drug resource which provides up-to-date information on one of the most rapidly changing areas of medicine. Easy to follow, providing practical advice on how to manage cardiac diseases with a focus on hands-on therapeutic guidance for the clinicians. Text talks about all of the drug-groups useful in various indications like drugs for acute coronary syndromes, dyslipidemia, hypertension, pulmonary hypertension, angina, etc. along with data from clinical trials. This book is exhaustive coverage of newly evolving co-morbid conditions with chapters on metabolic syndrome and pregnancy. Future directions: Pharmacogenomics elaborates on gene interactions with cardiovascular drugs. The unique feature of this book is the detailed discussion on the guidelines of the American College of Cardiology/American Heart Association for the use of pharmacologic agents in various clinical conditions. It is enhanced with four colour illustrations and images, illustrating the key pharmacological and physiological actions. It is useful for cardiologist, pharmacologist, physicians, clinicians and specialist.

The Esc Handbook On Cardiovascular Pharmacotherapy

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Author : Juan Carlos Kaski
language : en
Publisher: European Society of Cardiology
Release Date : 2019-05-23

The Esc Handbook On Cardiovascular Pharmacotherapy written by Juan Carlos Kaski and has been published by European Society of Cardiology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-23 with Medical categories.

The ESC Handbook on Cardiovascular Pharmacotherapy, based on the most recent guidelines in cardiovascular pharmacology, and containing a comprehensive A-Z formulary of common and less commonly used cardiac drugs and drug groups, provides practical and accessible guidance on all areas of drugprescribing.Previously published as Drugs in Cardiology, this new edition has been developed by the ESC Working Group on Cardiovascular Pharmacology. Pharmacology is an integral aspect in almost all disciplines within cardiology and all cardiologists use cardiovascular drugs.Completely updated and aligned with the ESC Clinical Practice Guidelines for prescribing, this handbook is essential reading for consultants, registrars in training, general practitioners, specialist cardiac nurses and cardiovascular pharmacologists.

The Esc Textbook Of Preventive Cardiology

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Author : Stephan Gielen
language : en
Publisher: European Society of Cardiology
Release Date : 2015

The Esc Textbook Of Preventive Cardiology written by Stephan Gielen and has been published by European Society of Cardiology this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Medical categories.

"EACPR, European Association for Cardiovascular Prevention and Rehabilitation -- European Society of Cardiology."