Cardiovascular Specific Gene Expression
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Cardiovascular Specific Gene Expression
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Author : P.A.F.M. Doevendans
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Cardiovascular Specific Gene Expression written by P.A.F.M. Doevendans and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
Improving our insights into the genetic predisposition to cardiovascular disease is one of the most important challenges in our field in the next millennium, not only to unravel the cause of disease but also to improve the selection of patients for particular treatments. Nowadays, for example, subjects with a cholesterol above a particular plasma level are exposed to a cholesterol lowering regime based upon the beneficial outcome of epidemiological studies which include subjects not prone to the disease, despite a plasma cholesterol above the accepted level. Identification of the patients who are genetically predisposed to the consequences of this disorder will reduce the number of subjects unnecessarily treated and, hence, the costs of health care. Because in most cardiovascular diseases the genetic component is a consequence of more than one gene defect, only limited progress has as yet been made in identifying subjects genetically at risk. For example, in hypertension only in less than 10% of the patients the genetic defect has been identified. It has been known for quite some time that in heart and blood vessels fetal genes are as high blood pressure and upregulated or induced when they are exposed to such disorders ischemia. Little is known about the function of these genes in the cardiac and vascular adaptation to these disorders; only guesses can be made.
Cardiac Gene Expression
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Author : Jun Zhang
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Cardiac Gene Expression written by Jun Zhang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
This book presents both cutting-edge and established methods for studying cardiac gene expression. The protocols provide a template for solid research, and cover the process through screening, analysis, characterization, and functional confirmation of novel genes or known genes with a new function. The concluding section of the book highlights methods that facilitate overexpression or cardiac-specific targeted gene deletion.
Studies On The Transcriptional Regulation Of The Cardiac Muscle Specific Gene Expression
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Author : Yimin Zou
language : en
Publisher:
Release Date : 1995
Studies On The Transcriptional Regulation Of The Cardiac Muscle Specific Gene Expression written by Yimin Zou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Cardiac Specific Gene Expression Of The Regulatory Myosin Light Chains
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Author : Pieter A. F. M. Doevendans
language : en
Publisher:
Release Date : 1997
Cardiac Specific Gene Expression Of The Regulatory Myosin Light Chains written by Pieter A. F. M. Doevendans and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.
Cardiovascular Genomics New Pathophysiological Concepts
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Author : P.A.F.M. Doevendans
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cardiovascular Genomics New Pathophysiological Concepts written by P.A.F.M. Doevendans and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Four years ago-in December 1997-the first European Science Foundation Workshop on Cardiovascular Specific Gene Expression was held in Maastricht. It was hardly possible to imagine the progress in the field in those four years. In 1997, gene expression was still an art focused on individual genes; in 200 I, many labs have access to micro-array facilities to determine the expression of thousands of genes simultaneously. In 1997, gene expression was an area of fundamental research in basis molecular biology laboratories; in 200 I, clinical cardiovascular research has incorporated gene expression approaches. In 1997, the interpretation of a gene expression experiment was usually straightforward; in 200 I, advanced bioinformatics tools are needed to approach the extreme complexities of genetic control of cell and tissue function. The second symposium in this series is focused on Cardiovascular Genomics. New Pathophysiological Concepts. The organizing committee chose to invite a group of renown scientists and young investigators around four topics of eminent importance in cardiovascular research. These topics reflect the major present-day clinical cardiovascular problems: atherosclerosis, hypertension, arrhythmias and heart failure. In addition to these four disease-driven topics, the workshop has sessions on gene expression methodologies and cellular transplant approaches to cardiovascular disease.
Cardiac Gene Therapy
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Author : Kiyotake Ishikawa
language : en
Publisher: Springer Nature
Release Date : 2022-08-30
Cardiac Gene Therapy written by Kiyotake Ishikawa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-30 with Science categories.
This second edition volume expands on the previous edition with updated techniques and discussions on topics such as gene suppression, editing, and reprogramming; cardiac gene therapy vectors and promoters; cardiac gene delivery methods; pulmonary hypertension; and patient screening and measuring the efficacy of cardiac gene therapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Cardiac Gene Therapy: Methods and Protocols, Second Edition is a valuable tool for researchers in cardiology who are conducting gene therapy research. This book will lead to further advancements and successful clinical translations in the field. Chapter “Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Epigenetics In Cardiac Disease
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Author : Johannes Backs
language : en
Publisher: Springer
Release Date : 2016-11-21
Epigenetics In Cardiac Disease written by Johannes Backs and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-21 with Medical categories.
This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
Molecular Genetics Gene Therapy Of Cardiovascular Diseases
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Author : S. C. Mockrin
language : en
Publisher: CRC Press
Release Date : 1996-01-02
Molecular Genetics Gene Therapy Of Cardiovascular Diseases written by S. C. Mockrin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-02 with Medical categories.
Provides detailed discussions of the most recent developments in gene mapping and manipulation to improve the diagnosis, detection, prevention, and treatment of various cardiovascular diseases--including hypertension, arrhythmias, inherited cariomyopathies, hyperlipidemia, aortic aneurysms, Marfan syndrome, and myocardial infarction. Written by nea
Novel Roles For Jun Kinase In Cardiac Specific Gene Expression
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Author : Robert A. McKay
language : en
Publisher:
Release Date : 1999
Novel Roles For Jun Kinase In Cardiac Specific Gene Expression written by Robert A. McKay and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Cellular signal transduction categories.
Gene Transfer In The Cardiovascular System
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Author : Keith L. March
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gene Transfer In The Cardiovascular System written by Keith L. March and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The goal of gene transfer is protein expression. a process brought about by the insertion of a gene coding for a foreign protein into target cells resulting in the synthesis of the foreign protein For gene therapy, a tmnsferred therapeutic gene must be expressed at a level beneficial for the patient. This chapter provides an introductory overview of the rapidly evolving field of non-viral approaches for gene delivery to rnarnrnalian cells. Although currently there are fewer ongoing clinical trials using non-viral approaches than those using viral based systems, the number of non-viral trials is increasing. The long range goal of some research groups is the development of a genetically engineered artificial virus targeted to specific cells in the human body. An arurual conference, organized by Cambridge Healthtech Institute entitled "Artificial Self-Assembling Systems for Gene Transfer", brings together researchers interested in this field [1]. Assembly of an artificial virus is very complex; other research groups aim to develop simpler delivery systems consisting of a plasmid combined with delivery agents. Viral-based systems are very successful for gene delivery, but despite their successes, viral-based systems have some geneml limitations and system-specific limitations. When employing a viml-based system, the following limitations should be considered: • size limitation of the inserted gene due to packaging constraints (e. g. adenovirus, retrovirus) . • potential tumorigenesis (e. g. retrovirus) • potential for insertional mutagenesis (greater than plasmid based systems) • potential imrnunogenicity (e. g.