Care Use And Welfare Of Marmosets As Animal Models For Gene Editing Based Biomedical Research
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Care Use And Welfare Of Marmosets As Animal Models For Gene Editing Based Biomedical Research
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-08-26
Care Use And Welfare Of Marmosets As Animal Models For Gene Editing Based Biomedical Research written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-26 with Science categories.
The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop.
Care Use And Welfare Of Marmosets As Animal Models For Gene Editing Based Biomedical Research
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Author : Engineering National Academies of Sciences (and Medicine)
language : en
Publisher:
Release Date : 2019
Care Use And Welfare Of Marmosets As Animal Models For Gene Editing Based Biomedical Research written by Engineering National Academies of Sciences (and Medicine) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Gene editing categories.
"The marmoset, a type of small monkey native to South America, is a research model of increasing importance for biomedical research in the United States and globally. Marmosets offer a range of advantages as animal models in neuroscience, aging, infectious diseases, and other fields of study. They may be particularly useful for the development of new disease models using genetic engineering and assisted reproductive technologies. However, concerns have been voiced with respect to the development of new marmoset-based models of disease, ethical considerations for their use, the supply of marmosets available for research, and gaps in guidance for their care and management. To explore and address these concerns, the Roundtable on Science and Welfare in Laboratory Animal Use hosted a public workshop on October 22-23, 2018, in Washington, DC. The workshop focused on the availability of marmosets in the United States and abroad; animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets; and standards of housing and care, dietary needs, and feeding requirements for marmosets in captivity. This publication summarizes the presentations and discussions from the workshop"--Publisher's description
Genome Editing In Neurosciences
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Author : Rudolf Jaenisch
language : en
Publisher:
Release Date : 2020-10-08
Genome Editing In Neurosciences written by Rudolf Jaenisch and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
Innovations in molecular biology are allowing neuroscientists to study the brain with unprecedented resolution, from the level of single molecules to integrated gene circuits. Chief among these innovations is the CRISPR-Cas genome editing technology, which has the precision and scalability to tackle the complexity of the brain. This Colloque Médecine et Recherche has brought together experts from around the world that are applying genome editing to address important challenges in neuroscience, including basic biology in model organisms that has the power to reveal systems-level insight into how the nervous system develops and functions as well as research focused on understanding and treating human neurological disorders. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Management Of Animal Care And Use Programs In Research Education And Testing
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Author : Robert H. Weichbrod
language : en
Publisher: CRC Press
Release Date : 2017-09-07
Management Of Animal Care And Use Programs In Research Education And Testing written by Robert H. Weichbrod and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-07 with Medical categories.
AAP Prose Award Finalist 2018/19 Management of Animal Care and Use Programs in Research, Education, and Testing, Second Edition is the extensively expanded revision of the popular Management of Laboratory Animal Care and Use Programs book published earlier this century. Following in the footsteps of the first edition, this revision serves as a first line management resource, providing for strong advocacy for advancing quality animal welfare and science worldwide, and continues as a valuable seminal reference for those engaged in all types of programs involving animal care and use. The new edition has more than doubled the number of chapters in the original volume to present a more comprehensive overview of the current breadth and depth of the field with applicability to an international audience. Readers are provided with the latest information and resource and reference material from authors who are noted experts in their field. The book: - Emphasizes the importance of developing a collaborative culture of care within an animal care and use program and provides information about how behavioral management through animal training can play an integral role in a veterinary health program - Provides a new section on Environment and Housing, containing chapters that focus on management considerations of housing and enrichment delineated by species - Expands coverage of regulatory oversight and compliance, assessment, and assurance issues and processes, including a greater discussion of globalization and harmonizing cultural and regulatory issues - Includes more in-depth treatment throughout the book of critical topics in program management, physical plant, animal health, and husbandry. Biomedical research using animals requires administrators and managers who are knowledgeable and highly skilled. They must adapt to the complexity of rapidly-changing technologies, balance research goals with a thorough understanding of regulatory requirements and guidelines, and know how to work with a multi-generational, multi-cultural workforce. This book is the ideal resource for these professionals. It also serves as an indispensable resource text for certification exams and credentialing boards for a multitude of professional societies Co-publishers on the second edition are: ACLAM (American College of Laboratory Animal Medicine); ECLAM (European College of Laboratory Animal Medicine); IACLAM (International Colleges of Laboratory Animal Medicine); JCLAM (Japanese College of Laboratory Animal Medicine); KCLAM (Korean College of Laboratory Animal Medicine); CALAS (Canadian Association of Laboratory Animal Medicine); LAMA (Laboratory Animal Management Association); and IAT (Institute of Animal Technology).
Animal Experimentation Working Towards A Paradigm Change
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Author : Kathrin Herrmann
language : en
Publisher: BRILL
Release Date : 2019-04-30
Animal Experimentation Working Towards A Paradigm Change written by Kathrin Herrmann and has been published by BRILL this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-30 with Philosophy categories.
Animal experimentation has been one of the most controversial areas of animal use, mainly due to the intentional harms inflicted upon animals for the sake of hoped-for benefits in humans. Despite this rationale for continued animal experimentation, shortcomings of this practice have become increasingly more apparent and well-documented. However, these limitations are not yet widely known or appreciated, and there is a danger that they may simply be ignored. The 51 experts who have contributed to Animal Experimentation: Working Towards a Paradigm Change critically review current animal use in science, present new and innovative non-animal approaches to address urgent scientific questions, and offer a roadmap towards an animal-free world of science.
Alternatives To Animal Use In Research Testing And Education
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Author :
language : en
Publisher:
Release Date : 1986
Alternatives To Animal Use In Research Testing And Education written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986 with Alternative toxicity testing categories.
The Common Marmoset In Captivity And Biomedical Research
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Author : Robert P. Marini
language : en
Publisher: Academic Press
Release Date : 2018-11-19
The Common Marmoset In Captivity And Biomedical Research written by Robert P. Marini and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-19 with Science categories.
The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the AmericanCollege of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset(Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such asmacaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. Themarmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primatemodel to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series
Occupational Health And Safety In The Care And Use Of Research Animals
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Author : Committee on Occupational Safety and Health in Research Animal Facilities
language : en
Publisher: National Academies Press
Release Date : 1997-06-23
Occupational Health And Safety In The Care And Use Of Research Animals written by Committee on Occupational Safety and Health in Research Animal Facilities and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-06-23 with Business & Economics categories.
Much has been written about the care of research animals. Yet little guidance has appeared on protecting the health and safety of the people who care for or use these animals. This book, an implementation handbook and companion to Guide For the Care and Use of Laboratory Animals, identifies principles for building a program and discusses the accountability of institutional leaders, managers, and employees for a program's success. It provides a detailed description of risks-- physical and chemical hazards, allergens and zoonoses, and hazards from experiments--which will serve as a continuing reference for the laboratory. The book offers specific recommendations for controlling risk through administrative procedures, facility design, engineering controls, and periodic evaluations. The volume focuses on the worker, with detailed discussions of work practices, the use of personal protective gear, and the development of an emergency response plan. This handbook will be invaluable to administrators, researchers, and employees in any animal research facility. It will also be of interest to personnel in zoos, animal shelters, and veterinary facilities.
The Oxford Handbook Of Practical Ethics
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Author : Hugh LaFollette
language : en
Publisher: Oxford Handbooks Online
Release Date : 2005-09-15
The Oxford Handbook Of Practical Ethics written by Hugh LaFollette and has been published by Oxford Handbooks Online this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-15 with Law categories.
This is a guide to contemporary thought on ethical issues in all areas of human activity - personal, medical, sexual, social, political, judicial, and international, from the natural world to the world of business.
Guide To The Care And Use Of Experimental Animals
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Author :
language : en
Publisher:
Release Date : 1980
Guide To The Care And Use Of Experimental Animals written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Animal experimentation categories.