Genome Editing In Neurosciences
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Genome Editing In Neurosciences
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Author : Rudolf Jaenisch
language : en
Publisher: Springer
Release Date : 2017-09-14
Genome Editing In Neurosciences written by Rudolf Jaenisch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-14 with Medical categories.
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Genome Editing In Neurosciences
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Author : Rudolf Jaenisch
language : en
Publisher: Springer
Release Date : 2018-08-11
Genome Editing In Neurosciences written by Rudolf Jaenisch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-11 with Medical categories.
This book is open access under a CC BY 4.0 license. CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease. This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Crispr Cas9 Based Genome Editing For Treating Genetic Disorders And Diseases
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Author : Luis María Vaschetto
language : en
Publisher: CRC Press
Release Date : 2022-01-31
Crispr Cas9 Based Genome Editing For Treating Genetic Disorders And Diseases written by Luis María Vaschetto and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-31 with Mathematics categories.
The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.
Brain Development
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Author : Simon G. Sprecher
language : en
Publisher: Humana
Release Date : 2020-09-26
Brain Development written by Simon G. Sprecher and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-26 with Science categories.
This book provides a thorough introduction to widely used techniques for the study of the intersection between developmental biology and neuroscience, an exceptional area to address and investigate impacting biological questions. The fully updated volume examines cutting-edge techniques on a representative range of animals, including widely used genetic model systems, such as the fruit fly, zebra fish, chicken, and mouse, as well as non-canonical experimental systems opened up through the advent of genome editing. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Brain Development: Methods and Protocols, Second Edition is an ideal guide for researchers interested in utilizing recent technical advances in molecular genetics for the study of the brain.
Gene Therapy In Neurological Disorders
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Author : Mingjie Li
language : en
Publisher: Academic Press
Release Date : 2018-05-25
Gene Therapy In Neurological Disorders written by Mingjie Li and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-25 with Medical categories.
Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases
Genome Editing For Neurodegenerative Diseases
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Author : Sandeep Kumar Singh
language : en
Publisher: Academic Press
Release Date : 2024-09-01
Genome Editing For Neurodegenerative Diseases written by Sandeep Kumar Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-01 with Medical categories.
Genome Editing for Neurodegenerative Diseases: From Concept to Clinical Trials examines recent advances in neurodegenerative disease research and clinical challenges in practical applications. With an emphasis on genome editing tools such as ZFNs, TALENSs and CRISPR-Cas, this book sheds light on the possibilities to counteract genetic and neurodegenerative diseases. It will be of interest to researchers in neuroscience and biopharmaceuticals, as well as clinicians specializing in neurodegenerative diseases.
Transgenic Neuroscience Research
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2019-04-03
Transgenic Neuroscience Research written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-03 with Medical categories.
To examine the promise, concerns, and challenges related to neuroscience research using genetically modified nonhuman primates, the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 4, 2018, bringing together an international group of experts and stakeholders representing academia, industry, laboratory animal management, disease-focused foundations, and federal agencies. The workshop was designed to explore the current state and future promise of research using genetically modified nonhuman primate models of disease to understand the complex functions of the brain that control behavior, movement, and cognition in both health and disease states. This publication summarizes the presentations and discussions from the workshop.
Reprogramming The Genome Crispr Cas Based Human Disease Therapy
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Author : Vijai Singh
language : en
Publisher: Elsevier
Release Date : 2021-06-15
Reprogramming The Genome Crispr Cas Based Human Disease Therapy written by Vijai Singh and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-15 with Science categories.
Reprogramming the Genome: CRISPR-Cas-based Human Disease Therapy, presents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 is a key technology for targeted genome editing and regulation in a number of organisms including mammalian cells. It is a rapid, simple, and cost-effective solution. CRISPR-Cas system has recently gained much scientific and public attention. This volume covers CRISPR-Cas9 based mammalian genome editing, creating disease models, cancer therapy, neurological, heredity, blood disorders, defective gene correction, stem cells therapy, epigenetic modifications, patents, ethics, biosafety and regulatory issues challenges and opportunities. This book is a key source of information on mammalian genome editing available in a single volume. This book will be useful for beginners in mammalian genome editing and also students, researchers, scientists, policymakers, clinicians and stakeholders interested in genome editing in several areas. Offers basic understanding and a clear picture of mammalian genome editing through CRISPR-Cas systems Discusses how to create mammalian disease models, stem cell modification, epigenetic modifications, correction of defective gene in blood disorders, heredity, neurological disorders and many more Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology, translational sciences, neurobiology, neurology, cancer, stem cells, and many more
Neurotechnology
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Author : James Giordano
language : en
Publisher: CRC Press
Release Date : 2012-04-26
Neurotechnology written by James Giordano and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-26 with Science categories.
New technologies that allow us to investigate mechanisms and functions of the brain have shown considerable promise in treating brain disease and injury. These emerging technologies also provide a means to assess and manipulate human consciousness, cognitions, emotions, and behaviors, bringing with them the potential to transform society. Neurotechnology: Premises, Potential, and Problems explores the technical, moral, legal, and sociopolitical issues that arise in and from today’s applications of neuroscience and technology and discusses their implications for the future. Some of the issues raised in this thought-provoking volume include: Neurotechnology in education: an enablement, a treatment, or an enhancement? The potential and limitations of neuroimaging technology in determining patient prognoses Tissue implantation technology as a way of engendering personalized medicine Neuroprostheses: restoration of functions of the disabled vs. enhancement to transhuman capabilities Deep brain stimulation and its use in restoring, preserving, or changing patients’ personal identity The benefit and risk of cognitive performance tools Cyborg technology and its potential to change our vision of humanity Methodologies for reducing the risk of neurotechnology’s impact on ethical, legal, and social issues With contributions from an international group of experts working on the cutting edge of neurotechnology, this volume lays the groundwork to appreciate the ethical, legal, and social aspects of the science in ways that keep pace with this rapidly progressing field.
Psychotherapy In An Age Of Neuroscience
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Author : Joel Paris
language : en
Publisher: Oxford University Press
Release Date : 2017
Psychotherapy In An Age Of Neuroscience written by Joel Paris and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Psychology categories.
Psychiatry, once proud of its biopsychosocial model, has now adopted a neuroscience-based approach that strongly favors psychopharmacological treatments and downplays the role of psychotherapies (or social interventions). This kind of practice can be sufficient for the psychoses, but it is neither evidence-based nor beneficial for patients with common mental disorders such as depression, anxiety, substance use, and personality disorders. Current practice derives from a theoretical model in which psychiatry is viewed primarily as an application of neuroscience, with little reference to the vast literature on psychology, social sciences, and psychotherapy. This work reviews research bearing on these issues, and it shows why existing data support a different set of conclusions from those held by many experts and most practitioners