Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease
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Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease
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Author : Rodrigo Del Rio
language : en
Publisher: Frontiers Media SA
Release Date : 2016-12-12
Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease written by Rodrigo Del Rio and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Physiology categories.
The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to restore normal CB chemoreflex function remains unsolved. Recent studies showing the effect of CB denervation in pathophysiology have unveiled a key role of these arterial chemoreceptors in the development of autonomic imbalance and respiratory disturbances, and suggest that targeting the CB could represent a novel strategy to improve disease outcome. Unfortunately, classical pharmacotherapy intended to normalize CB function may be hard to establish since several cellular pathways are involved in the CB dysfunction. Augmented levels of angiotensin II, endothelin-1, cytokines and free radicals along with decreases in nitric oxide had all been related to the CB dysfunction. Moreover, changes in expression of angiotensin receptors, nitric oxide synthases and cytokines that take place within the CB tissue in pathological states also contribute to the enhanced CB chemoreflex drive. It has been shown in heart failure, hypertension and obstructive sleep apnea that the CB becomes tonically hyper-reactive. During the progression of the disease this CB chemosensory facilitation process induces central nervous system plasticity. The altered autonomic-respiratory control leads to increased cardiorespiratory distress and the deterioration of the condition. The focus of this e-book will be to cover the role of the CB in pathophysiology and to provide new evidence of the pathways involved in the maladaptive potentiation of the CB chemoreflex function. In memory of Professor Mashiko Shirahata and Professor Constancio Gonzalez.
Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease
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Author :
language : en
Publisher:
Release Date : 2016
Carotid Body A New Target For Rescuing Neural Control Of Cardiorespiratory Balance In Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
The carotid body (CB) is in charge of adjusting ventilatory and cardiovascular function during changes in arterial blood gases. Regardless this essential function, the CB has been implicated in the sensing of other physiological signals such as changes in blood flow and glucose levels. More important, malfunction of the CB chemoreceptors has been associated with the progression and deterioration of several disease states such as hypertension, heart failure, renal failure, insulin resistance, diabetes and sleep apnea. Although the mechanisms involved in the alterations of the CB function in pathophysiology are currently under intense research, the development of therapeutic approaches to restore normal CB chemoreflex function remains unsolved. Recent studies showing the effect of CB denervation in pathophysiology have unveiled a key role of these arterial chemoreceptors in the development of autonomic imbalance and respiratory disturbances, and suggest that targeting the CB could represent a novel strategy to improve disease outcome. Unfortunately, classical pharmacotherapy intended to normalize CB function may be hard to establish since several cellular pathways are involved in the CB dysfunction. Augmented levels of angiotensin II, endothelin-1, cytokines and free radicals along with decreases in nitric oxide had all been related to the CB dysfunction. Moreover, changes in expression of angiotensin receptors, nitric oxide synthases and cytokines that take place within the CB tissue in pathological states also contribute to the enhanced CB chemoreflex drive. It has been shown in heart failure, hypertension and obstructive sleep apnea that the CB becomes tonically hyper-reactive. During the progression of the disease this CB chemosensory facilitation process induces central nervous system plasticity. The altered autonomic-respiratory control leads to increased cardiorespiratory distress and the deterioration of the condition. The focus of this e-book will be to cover the role of the CB in pathophysiology and to provide new evidence of the pathways involved in the maladaptive potentiation of the CB chemoreflex function. In memory of Professor Mashiko Shirahata and Professor Constancio Gonzalez.
Diagnostic Histopathology Of Tumors
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Author : Christopher D. M. Fletcher
language : en
Publisher: Elsevier Health Sciences
Release Date : 2019-12-10
Diagnostic Histopathology Of Tumors written by Christopher D. M. Fletcher and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-10 with Medical categories.
Known for its clear writing style, easy-to-navigate format, and authoritative coverage of tumor pathology, Dr. Christopher Fletcher’s Diagnostic Histopathology of Tumors, 5th Edition, remains your go-to source for accurate, efficient evaluation and interpretation of histopathology specimens. This highly regarded reference provides superbly illustrated information on pathogenesis, diagnostic criteria, molecular/cytogenetic findings, and prognosis on the neoplastic diseases most likely to be encountered by general surgical pathologists, and helps you stay current with the latest diagnostic tumor markers to assist in daily sign-out. Discusses the latest developments in immunohistochemistry, molecular genetics, targeted therapy/personalized medicine, and prognostic/predictive markers to assist in the diagnosis of the complete range of neoplastic entities. Includes coverage of newly described variants and new histologic entities. Covers all modern diagnostic techniques while retaining a strong emphasis on morphologic diagnosis, which remains the cornerstone of diagnosis for most lesions. Features thousands of high-quality photographs, photomicrographs, and artwork throughout. Incorporates the latest TNM and WHO classification and staging systems. Contains diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. Shares the knowledge and expertise of internationally renowned experts in tumor pathology, including Dr. Christopher Fletcher, as well as numerous global authorities in the field.
Autonomic Failure
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Author : Roger Bannister
language : en
Publisher: Oxford University Press, USA
Release Date : 1983
Autonomic Failure written by Roger Bannister and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Language Arts & Disciplines categories.
Life is a journey and we all have to go thru this progress. When I make wrong choices it was for a reason, it was for a purpose. I had to learn from it.I can not be ashamed of No one.I can not think that I am better then No One Else.I can not think less of No one Else.I can not talk about No One.Because My Father was not ashamed of Me.Because My Father did not think less of Me.Because My Father did not talk about my dirt or my sins to Anyone.Because My Father did not think that he was Better then me.HE ONLY LOVE ME
How Tobacco Smoke Causes Disease
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Author :
language : en
Publisher:
Release Date : 2010
How Tobacco Smoke Causes Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Government publications categories.
This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
The Arterial Chemoreceptors
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Author : Yoshiaki Hayashida
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-04-24
The Arterial Chemoreceptors written by Yoshiaki Hayashida and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-04-24 with Medical categories.
This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.
Regulation Of Coronary Blood Flow
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Author : Michitoshi Inoue
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-09
Regulation Of Coronary Blood Flow written by Michitoshi Inoue and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-09 with Medical categories.
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
The Carotid Body Chemoreceptors
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Author : Constancio Gonzalez
language : en
Publisher:
Release Date : 1997
The Carotid Body Chemoreceptors written by Constancio Gonzalez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Basic Physiology For Anaesthetists
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Author : David Chambers
language : en
Publisher: Cambridge University Press
Release Date : 2019-07-25
Basic Physiology For Anaesthetists written by David Chambers and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-25 with Medical categories.
Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.
Perioperative Hemodynamic Monitoring And Goal Directed Therapy
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Author : Maxime Cannesson
language : en
Publisher: Cambridge University Press
Release Date : 2014-09-04
Perioperative Hemodynamic Monitoring And Goal Directed Therapy written by Maxime Cannesson and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-04 with Medical categories.
Provides a comprehensive understanding of perioperative hemodynamic monitoring and goal directed therapy, emphasizing practical guidance for implementation at the bedside.