Causal Analysis In Biomedicine And Epidemiology
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Causal Analysis In Biomedicine And Epidemiology
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Author : Mikel Aickin
language : en
Publisher: CRC Press
Release Date : 2001-11-09
Causal Analysis In Biomedicine And Epidemiology written by Mikel Aickin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-09 with Mathematics categories.
"Provides current models, tools, and examples for the formulation and evaluation of scientific hypotheses in causal terms. Introduces a new method of model parametritization. Illustrates structural equations and graphical elements for complex causal systems."
Causal Inference And Scientific Paradigms In Epidemiology
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Author : Steven S. Coughlin
language : en
Publisher: Bentham Science Publishers
Release Date : 2010
Causal Inference And Scientific Paradigms In Epidemiology written by Steven S. Coughlin and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
This anthology of articles on causal inference and scientific paradigms in epidemiology covers several important topics including the search for causal explanations, the strengths and limitations of causal criteria, quantitative approaches for assessing causal relationships that are relevant to epidemiology and emerging paradigms in epidemiologic research. In order to provide historical context, an overview of philosophical and historical developments relevant to causal inference in epidemiology and public health is also provided. Several theoretical and applied aspects of causal inference are dealt with. The aim of this Ebook is not only to summarize important developments in causal inference in epidemiology but also to identify possible ways to enhance the search for causal explanations for diseases and injuries. Examples are provided from such fields as chronic disease epidemiology, Veterans health, and environmental epidemiology. A particular goal of the Ebook is to provide ideas for strengthening causal inference in epidemiology in the context of refined research paradigms. These topics are important because the results of epidemiologic studies contribute to generalizable knowledge by clarifying the causes of diseases, by combining epidemiologic data with information from other disciplines (for example, psychology and industrial hygiene), by evaluating the consistency of epidemiologic data with etiological hypotheses about causation, and by providing the basis for evaluating procedures for health promotion and prevention and public health practices.
Causal Analysis In Biomedicine And Epidemiology
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Author : Mikel Aickin
language : en
Publisher: CRC Press
Release Date : 2001-11-09
Causal Analysis In Biomedicine And Epidemiology written by Mikel Aickin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-09 with Mathematics categories.
"Provides current models, tools, and examples for the formulation and evaluation of scientific hypotheses in causal terms. Introduces a new method of model parametritization. Illustrates structural equations and graphical elements for complex causal systems."
Methods In Comparative Effectiveness Research
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Author : Constantine Gatsonis
language : en
Publisher: CRC Press
Release Date : 2017-02-24
Methods In Comparative Effectiveness Research written by Constantine Gatsonis and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-24 with Mathematics categories.
Comparative effectiveness research (CER) is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care (IOM 2009). CER is conducted to develop evidence that will aid patients, clinicians, purchasers, and health policy makers in making informed decisions at both the individual and population levels. CER encompasses a very broad range of types of studies—experimental, observational, prospective, retrospective, and research synthesis. This volume covers the main areas of quantitative methodology for the design and analysis of CER studies. The volume has four major sections—causal inference; clinical trials; research synthesis; and specialized topics. The audience includes CER methodologists, quantitative-trained researchers interested in CER, and graduate students in statistics, epidemiology, and health services and outcomes research. The book assumes a masters-level course in regression analysis and familiarity with clinical research.
Quantitative Evaluation Of Safety In Drug Development
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Author : Qi Jiang
language : en
Publisher: CRC Press
Release Date : 2014-12-08
Quantitative Evaluation Of Safety In Drug Development written by Qi Jiang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-08 with Mathematics categories.
State-of-the-Art Methods for Drug Safety Assessment Responding to the increased scrutiny of drug safety in recent years, Quantitative Evaluation of Safety in Drug Development: Design, Analysis and Reporting explains design, monitoring, analysis, and reporting issues for both clinical trials and observational studies in biopharmaceutical product development. It presents the latest statistical methods for drug safety assessment. The book’s three sections focus on study design, safety monitoring, and data evaluation/analysis. The book addresses key challenges across regulatory agencies, industry, and academia. It discusses quantitative approaches to safety evaluation and risk management in drug development, covering Bayesian methods, effective safety graphics, and risk-benefit evaluation. Written by a team of experienced leaders, this book brings the most advanced knowledge and statistical methods of drug safety to the statistical, clinical, and safety community. It shares best practices and stimulates further research and methodology development in the drug safety area.
Statistical Methods For Healthcare Performance Monitoring
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Author : Alex Bottle
language : en
Publisher: CRC Press
Release Date : 2016-08-05
Statistical Methods For Healthcare Performance Monitoring written by Alex Bottle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-05 with Mathematics categories.
Healthcare is important to everyone, yet large variations in its quality have been well documented both between and within many countries. With demand and expenditure rising, it’s more crucial than ever to know how well the healthcare system and all its components – from staff member to regional network – are performing. This requires data, which inevitably differ in form and quality. It also requires statistical methods, the output of which needs to be presented so that it can be understood by whoever needs it to make decisions. Statistical Methods for Healthcare Performance Monitoring covers measuring quality, types of data, risk adjustment, defining good and bad performance, statistical monitoring, presenting the results to different audiences and evaluating the monitoring system itself. Using examples from around the world, it brings all the issues and perspectives together in a largely non-technical way for clinicians, managers and methodologists. Statistical Methods for Healthcare Performance Monitoring is aimed at statisticians and researchers who need to know how to measure and compare performance, health service regulators, health service managers with responsibilities for monitoring performance, and quality improvement scientists, including those involved in clinical audits.
Bayesian Designs For Phase I Ii Clinical Trials
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Author : Ying Yuan
language : en
Publisher: CRC Press
Release Date : 2017-12-19
Bayesian Designs For Phase I Ii Clinical Trials written by Ying Yuan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-19 with Mathematics categories.
Reliably optimizing a new treatment in humans is a critical first step in clinical evaluation since choosing a suboptimal dose or schedule may lead to failure in later trials. At the same time, if promising preclinical results do not translate into a real treatment advance, it is important to determine this quickly and terminate the clinical evaluation process to avoid wasting resources. Bayesian Designs for Phase I–II Clinical Trials describes how phase I–II designs can serve as a bridge or protective barrier between preclinical studies and large confirmatory clinical trials. It illustrates many of the severe drawbacks with conventional methods used for early-phase clinical trials and presents numerous Bayesian designs for human clinical trials of new experimental treatment regimes. Written by research leaders from the University of Texas MD Anderson Cancer Center, this book shows how Bayesian designs for early-phase clinical trials can explore, refine, and optimize new experimental treatments. It emphasizes the importance of basing decisions on both efficacy and toxicity.
Translational Medicine
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Author : Dennis Cosmatos
language : en
Publisher: CRC Press
Release Date : 2008-12-17
Translational Medicine written by Dennis Cosmatos and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-17 with Mathematics categories.
Examines Critical Decisions for Transitioning Lab Science to a Clinical SettingThe development of therapeutic pharmaceutical compounds is becoming more expensive, and the success rates for getting such treatments approved for marketing and to the patients is decreasing. As a result, translational medicine (TM) is becoming increasingly important in
Analyzing Longitudinal Clinical Trial Data
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Author : Craig Mallinckrodt
language : en
Publisher: CRC Press
Release Date : 2016-12-12
Analyzing Longitudinal Clinical Trial Data written by Craig Mallinckrodt and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-12 with Mathematics categories.
Analyzing Longitudinal Clinical Trial Data: A Practical Guide provides practical and easy to implement approaches for bringing the latest theory on analysis of longitudinal clinical trial data into routine practice.The book, with its example-oriented approach that includes numerous SAS and R code fragments, is an essential resource for statisticians and graduate students specializing in medical research. The authors provide clear descriptions of the relevant statistical theory and illustrate practical considerations for modeling longitudinal data. Topics covered include choice of endpoint and statistical test; modeling means and the correlations between repeated measurements; accounting for covariates; modeling categorical data; model verification; methods for incomplete (missing) data that includes the latest developments in sensitivity analyses, along with approaches for and issues in choosing estimands; and means for preventing missing data. Each chapter stands alone in its coverage of a topic. The concluding chapters provide detailed advice on how to integrate these independent topics into an over-arching study development process and statistical analysis plan.
Biosimilar Clinical Development Scientific Considerations And New Methodologies
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Author : Kerry B. Barker
language : en
Publisher: CRC Press
Release Date : 2016-11-25
Biosimilar Clinical Development Scientific Considerations And New Methodologies written by Kerry B. Barker and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-25 with Mathematics categories.
Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in clinical development, this book discusses various potential drug development strategies, the design and analysis of pharmacokinetics (PK) studies, and the design and analysis of efficacy studies.