Cell Biology Of The Ubiquitin Proteasome System
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Cell Biology Of The Ubiquitin Proteasome System
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Author : R. John Mayer
language : en
Publisher: John Wiley & Sons
Release Date : 2008-06-25
Cell Biology Of The Ubiquitin Proteasome System written by R. John Mayer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-25 with Science categories.
The third of four volumes discusses the role of ubiquitin-mediated protein breakdown in cellular regulation and physiology. Required reading for molecular biologists, cell biologists and physiologists with an interest in the topic.
Protein Degradation
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Author : R. John Mayer
language : en
Publisher: Wiley-VCH
Release Date : 2006-10-27
Protein Degradation written by R. John Mayer and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-10-27 with Science categories.
Annotation. The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway. Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation. Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
Ubiquitin Proteasome System
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Author : Matthew Summers
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-06-19
Ubiquitin Proteasome System written by Matthew Summers and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with Science categories.
The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.
Ubiquitin
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Author :
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-12-09
Ubiquitin written by and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Science categories.
The ubiquitin-proteasome pathway consists of ubiquitin, substrate proteins, E1 enzymes, E2 enzymes, E3 enzymes, and proteasome, which acts in a series of enzymatic reaction chains to ubiquitinate substrate proteins such as surplus and misfolded proteins for degradation by the proteasome to maintain the balance between protein synthesis and degradation in a cell and tissue. Moreover, deubiquitinating enzymes can remove the attached ubiquitin chain, which results in a reverse ubiquitination-deubiquitination process involved in multiple biological processes in a cell and tissue. The changes of components in the ubiquitin-proteasome pathway are associated with multiple pathophysiological processes, such as cancers and neurodegenerative diseases. This book presents the new advances in concepts, analytical methodology, and application of ubiquitin-proteasome pathway for clarification of molecular mechanisms and discovery of new therapeutic targets and drugs in different diseases.
Ubiquitin And The Biology Of The Cell
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Author : Jan-Michael Peters
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Ubiquitin And The Biology Of The Cell written by Jan-Michael Peters and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
Protein Degradation
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Author : R. John Mayer
language : en
Publisher: Wiley-VCH
Release Date : 2005-04-15
Protein Degradation written by R. John Mayer and has been published by Wiley-VCH this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-04-15 with Science categories.
The first volume in a new series dedicated to protein degradation, this book lays the foundations of targeted protein breakdown via the ubiquitin pathway. The outstanding importance of the ubiquitin pathway has been recognized with the 2004 Nobel Prize in Chemistry for Aaaron Chiechanover, Avram Hershko, and Irwin Rose. Aaron Ciechanover is one of the editors of this series, and Avram Hershko has contributed to the opening chapter of the present volume. Drawing on the the expertise of two Nobel prize winners, this handy reference compiles information on the initial steps of the ubiquitin pathway. Starting out with a broad view of protein degradation and its functions in cellular regulation, it then goes on to examine the molecular mechanisms of ubiquitin conjugation and recycling in detail. All currently known classes of ubiquitin protein ligases are treated here, including latest structural data on these enzymes. Further volumes in the series cover the function of the proteasome, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states. Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
The Ubiquitin Proteasome System And Disease
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Author : R. John Mayer
language : en
Publisher: John Wiley & Sons
Release Date : 2008-06-25
The Ubiquitin Proteasome System And Disease written by R. John Mayer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-25 with Science categories.
This final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease. The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research. From the contents: * Ubiquitin and cancer * Ubiquitin and liver cancer * Muscle atrophy * Aggresomes and human disease * Parkin and neurodegeneration * Chronic neurodegenerative diseases * Parkinson's disease * Ubiquitin and viruses * Druggability of the ubiquitin-proteasome system Required reading for molecular and cell biologists, as well as physiologists with an interest in the topic.
Focus On The Ubiquitin Proteasome System
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Author :
language : en
Publisher:
Release Date : 2005
Focus On The Ubiquitin Proteasome System written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Proteolytic enzymes categories.
Ubiquitin Proteasome System
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Author : Aldrin V. Gomes
language : en
Publisher:
Release Date : 2018
Ubiquitin Proteasome System written by Aldrin V. Gomes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Science categories.
Over the last decade, major advancements in our understanding of the ubiquitin-proteasome system (UPS) have occurred. This book focuses on recent trends in the UPS. The UPS is possibly the most complex of all intracellular pathways - as close to 7% of all genes in the human genome make up part of the UPS. This complex system serves as an essential role in intracellular protein degradation, and because of its critical function, improper functioning of the UPS is associated with nearly all know diseases, including cancer, cardiovascular disease, and neurological diseases. The proteolytic component of the UPS is the proteasome, a multicatalytic complex found in the nucleus and cytoplasm. Another form of the proteasome, the immunoproteasome, is less abundant than the constitutive proteasome, but is important in immune response and degradation of oxidized proteins, and recent research suggests that it may be important in longevity. The articles in this book discuss recent findings which indicate that mutations in proteins involved with the UPS are associated with genetic diseases such as familial dilated cardiomyopathy, Nakajo syndrome, and spinal muscular atrophy (X-linked). Some chapters also discuss recent results which suggest that the UPS is heavily regulated by post-translational modifications such as phosphorylation, acetylation, and methylation. The UPS is also heavily regulated by ubiquitination itself. This book contains a research article using PubMed bibliometric data to present current research trends in the UPS. Articles are written so that no one tissue is emphasized to allow readers from any discipline to benefit from this information.
Ubiquitin Proteasome Proteolytic System The From Classical Biochemistry To Human Diseases
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Author : Aaron J Ciechanover
language : en
Publisher: World Scientific
Release Date : 2002-11-12
Ubiquitin Proteasome Proteolytic System The From Classical Biochemistry To Human Diseases written by Aaron J Ciechanover and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-12 with Science categories.
Ubiquitin-proteasome-dependent proteolysis is central to an incredible multitude of processes in all eukaryotes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, endocytosis, stress responses, antigen presentation and other aspects of the immune response, the functions of the nervous system including circadian rhythms, axon guidance and acquisition of memory.This book tells the story of the ubiquitin system as we currently know it: from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes.