Cell Commitment And Differentiation
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Cell Commitment And Differentiation
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Author : Norman Maclean
language : en
Publisher: Cambridge University Press
Release Date : 1987-08-13
Cell Commitment And Differentiation written by Norman Maclean and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987-08-13 with Science categories.
First published in 1987, this book is about how cells differentiate; that is it describes the way in which cells in animal and plant bodies take on their specialised fates. It has long been recognised that since all such cells retain copies of all genes, the genetic explanation for tissue differences lies in the controlled expression of restricted sets of genes. But how is the choice made and how are such restricted groups of genes activated and regulated? This book discusses these questions and describes both determination and differentiation. The mechanisms that underlie the processes are described for the embryo and in the adult. Determination may occur in adult life during regeneration, wound healing, cancer formation and in the immune and blood systems, and the possible genetic basis for the events is explored. The influence of the cell environment, the cell surface and the pericellular-extracellular matrix as mediators of external signals is discussed.
Molecular Mechanisms Of Cell Differentiation In Gonad Development
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Author : Rafal P. Piprek
language : en
Publisher: Springer
Release Date : 2016-06-14
Molecular Mechanisms Of Cell Differentiation In Gonad Development written by Rafal P. Piprek and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-14 with Science categories.
This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.
Mechanisms Of Differentiation
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Author : Paul B. Fisher
language : en
Publisher: CRC Press
Release Date : 1990-08-27
Mechanisms Of Differentiation written by Paul B. Fisher and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-08-27 with Medical categories.
Significant recent advances in cell culture technology now permit a detailed biochemical and molecular analysis of differentiation in both normal and tumor cells. These studies are important in attempting to understand the complex factors involved in normal growth and development, as well as the abnormalities associated with carcinogenesis. Mechanisms of Differentiation, Volumes I and II, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype. Mechanisms of Differentiation is valuable to researchers involved in differentiation and development, carcinogenesis, cell biology, chemotherapy, and immunology.
Stem Cells And Cns Development
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Author : Mahendra S. Rao
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-02-20
Stem Cells And Cns Development written by Mahendra S. Rao and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-02-20 with Science categories.
Stem Cells and CNS Development critically reviews recent findings on stem cells, their involvement in neurogenesis and gliogenesis, and the therapeutic implications of these findings. It defines by consensus the classes of stem cells in the nervous system, compares their similarities and differences, discusses the gains made in identifying human homologs of neural stem cells, and describes how these cells are beginning to be used for therapeutic purposes. Comprehensive and cutting-edge, this book provides all developmental scientists and neurobiologists not only an authoritative account of the current results in neural stem cell research, but also an incisive review of the rapidly emerging therapeutic uses of stem cells.
Cellular And Biochemical Science
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Author : G. Tripathi
language : en
Publisher: I. K. International Pvt Ltd
Release Date : 2010-03
Cellular And Biochemical Science written by G. Tripathi and has been published by I. K. International Pvt Ltd this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03 with Medical categories.
The fundamental aim underlying Cellular and Biochemical Sciences is to emphasize diversified topics of current interest to postgraduate students pursuing different courses in the area of biological sciences including Zoology, Botany, Biochemistry and Biotechnology. The text is also relevant to the students of Life Sciences, Biosciences, Cell Biology, Bioengineering and Pharmacology. A total of 58 topics have been incorporated in the book and some of the topics are rarely found in other books of Biology. New information has been introduced which updates existing knowledge and enables the book to justify its claim as the most comprehensive text in the sphere of cellular and biochemical sciences at the postgraduate and competitive examination levels. Each and every chapter has been designed in lucid and readable manner. There are references, suggested readings, long questions and objective questions at the end of chapters for revision of topics.
The Mechanobiology Of Obesity And Related Diseases
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Author : Amit Gefen
language : en
Publisher: Springer
Release Date : 2014-10-18
The Mechanobiology Of Obesity And Related Diseases written by Amit Gefen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-18 with Technology & Engineering categories.
This volume describes the state-of-knowledge in the study of the relationships between mechanical loading states in tissues and common pathophysiologies related to increase in mass of adipose tissues and/or hyperglycemia which eventually lead to obesity, diabetes, insulin resistance, hyperlipidemia, metabolic inflammations, certain types of cancer and other related diseases. There appears to be an interaction between the loading states in tissues and cells and these chronic conditions, as well as with factors such as age, gender and genetics of the individual. Bioengineering has made key contributions to this research field in providing technologies for cell biomechanics experimentation, microscopy and image processing, tissue engineering and multi-scale, multi-physics computational modeling. Topics at the frontier of this field of study include: the continuous monitoring of cell growth, proliferation and differentiation in response to mechanical factors such as stiffness of the extracellular matrix (ECM) and mechanical loads transferred through the ECM; mechanically-activated signaling pathways and molecular mechanisms; effects of different loading regimes and mechanical environments on differentiation fates of mesenchymal stem cells (MSCs) into myogenic and osteogenic versus adipogenic lineages; the interactions between nutrition and mechanotransduction; cell morphology, focal adhesion patterns and cytoskeletal remodeling changes in adipogenesis; activation of receptors related to diabetes by mechanical forces; brown and white adipose plasticity and its regulation by mechanical factors.
Proteoglycans In Stem Cells
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Author : Martin Götte
language : en
Publisher: Springer Nature
Release Date : 2021-06-07
Proteoglycans In Stem Cells written by Martin Götte and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-07 with Science categories.
This book provides a state-of-the-art compendium on the role of proteoglycans and glycosaminoglycans during development and in cancer. It also suggests directions for novel therapeutic and biotechnological applications in stem cell biology. Proteoglycans and glycosaminoglycans, as part of the extracellular matrix, are multifunctional modulators of growth factor, cytokine, integrin and morphogen signaling, which determine both self-renewal, senescence and/or differentiation of stem cells during development. Since proteoglycans modulate cell adhesion and migration they are important organizers of the extracellular matrix within the proper stem cell niche. A malfunctioning of proteoglycans and glycosaminoglycans contributes to the cancer stem cell phenotype, which is linked to therapeutic resistance and recurrence in malignant disease. This book is essential reading for anyone interested in the extracellular matrix and its role in development. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
Developmental Neurobiology
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Author : Greg Lemke
language : en
Publisher: Academic Press
Release Date : 2010-05-22
Developmental Neurobiology written by Greg Lemke and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-22 with Science categories.
Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbook reference exists on the market that provides researchers with more in-depth, high-level information on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole. This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject. - The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook information - The 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the Encyclopedia of Neuroscience by one of the great developmental neuroscientists, Greg Lemke - The best researchers in the field provide their conclusions in the context of the latest experimental results
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Bone Marrow Adipose Tissue Formation Function And Impact On Health And Disease
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Author : William P. Cawthorn
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-15
Bone Marrow Adipose Tissue Formation Function And Impact On Health And Disease written by William P. Cawthorn and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-15 with categories.
Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout.