Cell Division Machinery And Disease
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Cell Division Machinery And Disease
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Author : Monica Gotta
language : en
Publisher: Springer
Release Date : 2017-06-09
Cell Division Machinery And Disease written by Monica Gotta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-09 with Science categories.
This book critically evaluates the causal link between cell division machinery and disease. Further, it identifies key open questions in the field and the means for exploring them. Throughout the various chapters, internationally known contributors present the evidence for and against a causal link between key elements of the cell division machinery and diseases such as cancer, neuropathologies, aging, and infertility. A more clinically oriented chapter further discusses the current and future applications of anti-mitotic drugs in these diseases. Cell Division Machinery and Disease is essential reading for graduate or advanced graduate students, researchers or scientists working on cell division as well as clinicians interested in the molecular mechanisms of the discussed diseases.
Cell Cycle Control
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Author : Michele Pagano
language : en
Publisher: Springer
Release Date : 2013-10-03
Cell Cycle Control written by Michele Pagano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-03 with Science categories.
Addressing the regulation of the eukaryotic cell cycle, this book brings together experts to cover all aspects of the field, clearly and unambiguously, delineating what is commonly accepted in the field from the problems that remain unsolved. It will thus appeal to a large audience: basic and clinical scientists involved in the study of cell growth, differentiation, senescence, apoptosis, and cancer, as well as graduates and postgraduates.
Cell Cycle Control
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Author : Tim Humphrey
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Cell Cycle Control written by Tim Humphrey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
The fundamental question of how cells grow and divide has perplexed biologists since the development of the cell theory in the mid-19th century, when it was recognized by Virchow and others that “all cells come from cells.” In recent years, considerable effort has been applied to the identification of the basic molecules and mechanisms that regulate the cell cycle in a number of different organisms. Such studies have led to the elucidation of the central paradigms that underpin eukaryotic cell cycle control, for which Lee Hartwell, Tim Hunt, and Paul Nurse were jointly awarded the Nobel Prize for Medicine and Physiology in 2001 in recognition of their seminal contributions to this field. The importance of understanding the fundamental mechanisms that modulate cell division has been reiterated by relatively recent discoveries of links between cell cycle control and DNA repair, growth, cellular metabolism, development, and cell death. This new phase of integrated cell cycle research provides further challenges and opportunities to the biological and medical worlds in applying these basic concepts to understanding the etiology of cancer and other proliferative diseases.
Checkpoint Controls And Cancer
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Author : Axel H. Schönthal
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Checkpoint Controls And Cancer written by Axel H. Schönthal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Medical categories.
Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Cell Cycle Control And Dysregulation Protocols
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Author : Antonio Giordano
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Cell Cycle Control And Dysregulation Protocols written by Antonio Giordano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Medical categories.
Cell Cycle Control and Dysregulation Protocols focuses on emerging methodologies for studying the cell cycle, kinases, and kinase inhibitors. It addresses the issue of gene expression in vivo and in vitro, the analysis of cyclin-dependent kinase inhibitors, protein degradation mediated by the proteosome, the analysis of the transformed cell phenotype, and innovative techniques to detect apoptosis. Because there are already many manuals and protocols available, along with commercial kits and reagents, a variety of the more common techniques have not been included in our book. The protocols described, based on rather sophisticated techniques for in vivo and in vitro studies, consist of molecular biology, biochemistry, and various types of immunoassays. Indeed, the authors have successfully accomplished an arduous task by presenting several topics in the simplest possible manner. We are confident that Cell Cycle Control and Dysregulation Protocols will facilitate and optimize the work of practical scientists involved in researching the cell cycle. We greatly acknowledge the extraordinary contribution of the authors in writing this book.
Checkpoint Controls And Cancer
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Author : Axel H. Schönthal
language : en
Publisher: Humana Press
Release Date : 2004-06-04
Checkpoint Controls And Cancer written by Axel H. Schönthal and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-04 with Medical categories.
Intracellular checkpoint controls constitute a network of signal transd- tion pathways that protect cells from external stresses and internal errors. Ext- nal stresses can be generated by the continuous assault of DNA-damaging agents, such as environmental mutagens, ultraviolet (UV) light, ionizing radiation, or the reactive oxygen species that can arise during normal cellular metabolism. In response to any of these assaults on the integrity of the genome, the activation of the network of checkpoint control pathways can lead to diverse cellular responses, such as cell cycle arrest, DNA repair, or elimination of the cell by cell death (apoptosis) if the damage cannot be repaired. Moreover, internal errors can occur during the highly orchestrated replication of the cellular genome and its distribution into daughter cells. Here, the temporal order of these cell cycle events must be strictly enforced—for example, to ensure that DNA replication is c- plete and occurs only once before cell division, or to monitor mitotic spindle assembly, and to prevent exit from mitosis until chromosome segregation has been completed. Thus, well functioning checkpoint mechanisms are central to the maintenance of genomic integrity and the basic viability of cells and, the- fore, are essential for proper development and survival. The importance of proper functioning of checkpoints becomes plainly obvious under conditions in which this control network malfunctions and fails. Depending on the severity and timing, failure of this machinery can lead to embryonic lethality, genetic diseases, and cancer.
Cytotoxicity
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Author : Erman Salih Istifli
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-10-02
Cytotoxicity written by Erman Salih Istifli and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-02 with Medical categories.
Compensating for cytotoxicity in the multicellular organism by a certain level of cellular proliferation is the primary aim of homeostasis. In addition, the loss of cellular proliferation control (tumorigenesis) is at least as important as cytotoxicity, however, it is a contrasting trauma. With the disruption of the delicate balance between cytotoxicity and proliferation, confrontation with cancer can inevitably occur. This book presents important information pertaining to the molecular control of the mechanisms of cytotoxicity and cellular proliferation as they relate to cancer. It is designed for students and researchers studying cytotoxicity and its control.
Pancreatic Cancer
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Author : John P. Neoptolemos
language : en
Publisher:
Release Date : 2006
Pancreatic Cancer written by John P. Neoptolemos and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Annual Plant Reviews Cell Cycle Control And Plant Development
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Author : Dirk Inzé
language : en
Publisher: Wiley-Blackwell
Release Date : 2007-06-25
Annual Plant Reviews Cell Cycle Control And Plant Development written by Dirk Inzé and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-06-25 with Science categories.
The cell cycle in plants consists of an ordered set of events, including DNA replication and mitosis, that culminates in cell division. As cell division is a fundamental part of a plant's existence and the basis for tissue repair, development and growth, a full understanding of all aspects of this process is of pivotal importance. Cell Cycle Control and Plant Development commences with an introductory chapter and is broadly divided into two parts. Part 1 details the basic cell machinery, with chapters covering cyclin-dependent kinases (CDKs), cyclins, CDK inhibitors, proteolysis, CDK phosphorylation, and E2F/DP transcription factors. Part 2, which describes the cell cycle and plant development, covers cell cycle activation, cell cycle control during leaf development, endoreduplication, the cell cycle and trichome, fruit and endosperm development, the hormonal control of cell division and environmental stress, and cell cycle exit. The editor of this important book, Professor Dirk Inzé, well known and respected internationally, has brought together an impressive team of contributing authors, providing an excellent new volume in Blackwell Publishing's Annual Plant Reviews Series. The book is an essential purchase for research teams working in the areas of plant sciences and molecular, cell and developmental biology. All libraries in universities and research establishments where biological sciences are studied and taught should have copies of this essential and timely volume.