Cell Injury
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Cell Injury
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Author : Raphael Carl Lee
language : en
Publisher:
Release Date : 2005
Cell Injury written by Raphael Carl Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
When cells are damaged, as often occurs during trauma and metabolic stress, a highly evolved cell healing process follows that was designed to enhance cell survival or remove irreparably injured cells. Following injury, cells attempt to seal breaks in their membranes, chaperone removal or refolding of altered proteins, repair damaged DNA, or if necessary commit to programmed cell death. When cell injury is too extensive to permit reparative responses, acute cellular necrosis or apoptosis can result. Understanding injury at the subcellular organelle and molecular levels is essential for development of new therapeutic strategies and for optimal management of injured victims. In this volume, various modes of injury that can occur are described, as well as the basic molecular healing responses and pathways of metabolic survival or death.
Cell Injury And Protection In The Gastrointestinal Tract
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Author : Gyula Mózsik
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell Injury And Protection In The Gastrointestinal Tract written by Gyula Mózsik and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The scientific main programmes of these series of symposia changed from time to time following the international scientific trends. The main programmes of the First Symposium were: 1. Gastric and intestinal cytoprotection; 2. Hepatoprotection; 3. Pancreatic protection. For the second one: 1. Gastrointestinal mucosal 'cytoprotection'; 2. Liver 'cytoprotection'; 3. Pancreatic 'cytoprotection'; 4. Free radicals and scavangers; 5. Computer approach to cytoprotec tion. For the third one: 1. Basic, central, peripheral and cellular mechanisms of gastrointestinaol cytoprotection; 2. Esophagal protection; 3. Gastric protection; 4. Small intestinal injury and protection; 5. Large bowel injury and protection; 6. Liver injury and protection; 7. Pancreas injury and protection. The main scientific programmes of the Fourth International Symposium on 'Cell Injury and Protection in the Gastrointestinal Tract' are: 1. General mechanisms of gastrointestinal injury and protection; 2. Cell injury and protection in the stomach; 3. Cell injury and protection in the small intestine and in the large bowel; 4. Cell injury and protection in the liver and pancreas; 5. Cell injury and protection of the premalignant status and malignant diseases in the gastrointestinal tract. The presented papers are published in this book. The abstracts of this meeting were published in Digestive Diseases and Sciences, and we record appreciation of the Editor ofthatjoumal for their publication. Some of the papers published here have appeared in Inflammopharmacology 1996;4:331-398.
Mechanisms Of Cell Injury And Cell Death
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Author : B. A. Fowler
language : en
Publisher: Routledge
Release Date : 1989-12
Mechanisms Of Cell Injury And Cell Death written by B. A. Fowler and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-12 with categories.
Cell Injury
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Author : Dante G. Scarpelli
language : en
Publisher:
Release Date : 1971
Cell Injury written by Dante G. Scarpelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Cells categories.
Cell Biology Of Trauma
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Author : John J. Lemasters
language : en
Publisher: CRC Press
Release Date : 2020-08-16
Cell Biology Of Trauma written by John J. Lemasters and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-16 with Science categories.
This unique book presents an approach to viewing trauma. It examines the cellular consequences of trauma at a molecular level and provides new insights into the treatment of traumatic injury, based on cellular responses. The current of trauma research is reviewed, previously unpublished information on the topic is presented, and research directions are included.
Oxygen Nitrogen Radicals Cell Injury And Disease
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Author : Val Vallyathan
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Oxygen Nitrogen Radicals Cell Injury And Disease written by Val Vallyathan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.
Cell Injury
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Author : Edward Bittar
language : en
Publisher: Elsevier Science
Release Date : 1998-08-25
Cell Injury written by Edward Bittar and has been published by Elsevier Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-25 with Science categories.
At no time since the introduction of cell pathology by Virchov more than a century ago has the outlook for pathology as an integrated discipline been brighter. It is surely clear that the revolution of molecular biology and biotechnology has wrought profound changes in the various basic medical sciences including pathology. But to say this is hardly enough, particularly since the burgeoning field of molecular pathology has been challenged and altered by a powerful concept, namely, programmed cell death. Called apoptosis, which in Greek means falling off, it is intimately connected with cell removal and regeneration; that is, with tissue homeostasis. Nowhere is this more dramatically illustrated as a physiological process than in the gut, endometrium, and embryo. Similarly, little doubt is left that clusters of apoptotic-induced genes are involved in the control of carcinogenesis. The evidence for this is already compelling; it is plain, for instance, that p53 triggers apoptosis whenever DNA repair is incomplete. The question now is, how quickly can the Genome project shed some light on the genetics underlying apoptosis? It is tolerably clear that there is no such thing as a general model of cell injury, but there are models, as it should be. One thing is already certain: cell stress during septicemia is the quintessential model. Death here requires the failure of at least three organs! We are told that oxidative stress plays a major role in the pathogenesis of the syndrome. This is not surprising. The whole subject of reactive oxygen species (ROS) is thus given much weight. By far, the most important mechanisms underlying membrane lesions, due to ROS, are those involving inactivation of several key enzymes among a host of enzymes, lipid peroxidation, and iron speeding up bydroxyl radical production. The stark fact is that evolutionary pressure has produced a fiasco by not endowing the cell with enough antioxidant power or reducing the ROS pool. In organs with high O2 consumption, mitochondrial leakage of O2 (the superoxide anion) could well be considerable. Thus our main point here is that caloric restriction gives us a way of tackling the problem for the time being. One has only to remember that it improves survival. Whether there has been a "breakthrough" is not yet quite certain, but oxidative stress combined with long-term overactivation of glutamate receptors may enable us to understand several neurodegenerative disorders including Parkinson's disease. This broad topic is touched upon in detail in the Neurobiology module (Volume 14). There is a vast literature relating to injury of heart muscle. Two chapters address this topic. Looking back, are we to conclude that a membrane lesion, which is essentially functional, does not exist? Consider, as an example, the NMR experiments in which a raised Pco2, leads very rapidly to a fall in heart muscle pH. We also venture whether it begs several fundamental questions relating to events that precede the onset of necrobiosis. A telling argument is that an early event could be as simple as the root of the problem in ischemia is not as simple as that of a leaky membrane. But the initiating event would seem to be a redox imbalance vix., changes in cytosolic and mitochondrial NAD+/NADH. We urge the student to go back to Volume 4 (Part II) and read, once more, the chapter on Cellular ATP by Harris. In Part IV, the chapter on the Human Heat Shock Response by Jurivich merits a second reading. Though the present volume is a veritable source of many unanswered questions, it has the distinct simplicity of telling us that molecular pathology, like molecular biology, represents a way of thinking.
Free Radical Mechanisms Of Tissue Injury
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Author : Mary Treinen Moslen
language : en
Publisher: CRC Press
Release Date : 1992-02-21
Free Radical Mechanisms Of Tissue Injury written by Mary Treinen Moslen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-02-21 with Science categories.
This timely volume describes the contributions of free radicals and reactive oxygen species to disease processes in a variety of tissues. Topics include the roles of lipid peroxide-modified lipoproteins in atherosclerosis, peroxidation products in retinopathy, reactive oxygen species and neutrophils in mycardial ischemia-reflow injury, iron and reactive oxygen species in hemoglobin-mediated CNS damage and in asbestos-mediated lung injury. Critical reviews examine the evidence for radical species in ethanol-induced liver injury and in muscular dystrophy. The wealth of new information presented makes this book valuable for teaching and an important reference volume for researchers exploring problems in human disease.
Cell Injury And Cell Death
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Author : Byron Pennington Croker
language : en
Publisher:
Release Date : 1971
Cell Injury And Cell Death written by Byron Pennington Croker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1971 with Cell physiology categories.
Cell Death
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Author : Wolfgang J. Mergner
language : en
Publisher: Field & Wood Medical Publishers
Release Date : 1990
Cell Death written by Wolfgang J. Mergner and has been published by Field & Wood Medical Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medical categories.
The question is why cells die, and this treatment owes as much to medicine and pathology as to cell biology. Human disease (myocardial infarct, ischemic renal necrosis, the shock liver, cyanide poisoning, immune injury, poisoning by heavy metals, etc.) is the reference of the discussion of cell injury and cell death, which is integrated into the larger medical project of expanding means of patient care and the cure of disease. Annotation copyrighted by Book News, Inc., Portland, OR