Cell Surface Receptors A Short Course On Theory And Methods
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Cell Surface Receptors
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Author : Lee E. Limbird
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Cell Surface Receptors written by Lee E. Limbird and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
The purpose of this book is to serve as a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying prin ciples is intended to remove the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, it is hoped that the basic concepts can be emphasized. This book is meant to be a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed. I feit compelled to write this book for several reasons. The primary philosophical reason was to provide, in one volume, an overall perspective on the study ofcell surface receptors that describes their characterization from pharmacological studies in a whole organ or tissue bath (chapter 2) to studies of radioligand binding in isolated membrane and detergent-solubilized pre parations (chapters 3-5) and, back again, to studies in intact cells or tissues using morphological and biochemical techniques (chapter 6). It is my opinion that the ultimate understanding of the molecular basis for hormone or drug receptor interactions, and the physiological consequences of these inter actions, will require an assessment of cell surface receptor function at all of these experimental levels. In many cases an investigator may not choose to of investigation considered here.
Cell Surface Receptors A Short Course On Theory And Methods
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Author : Lee E. Limbird
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell Surface Receptors A Short Course On Theory And Methods written by Lee E. Limbird and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying principles removes the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, the basic concepts become emphasized. This volume is a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed.
Cell Surface Receptors
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Author : Lee E. Limbird
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-06-02
Cell Surface Receptors written by Lee E. Limbird and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-02 with Medical categories.
Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.
Cell Surface Receptors
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Author : Lee E. Limbird
language : en
Publisher: Springer
Release Date : 2004-11-12
Cell Surface Receptors written by Lee E. Limbird and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-12 with Medical categories.
Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.
Comprehensive Toxicology
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Author :
language : en
Publisher: Elsevier
Release Date : 2010-06-01
Comprehensive Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-01 with Science categories.
An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
Receptors Models For Binding Trafficking And Signaling
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Author : Douglas A. Lauffenburger
language : en
Publisher: Oxford University Press
Release Date : 1996-05-02
Receptors Models For Binding Trafficking And Signaling written by Douglas A. Lauffenburger and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-02 with Medical categories.
This book offers a bridge at the interface between engineering and cell biology, demonstrating how a mathematical modelling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor ligand interactions. Model frameworks are described over the entire spectrum of receptor processes, from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioural functions they govern, including proliferation, adhesion, and migration.
Handbook Of Methods In Gastrointestinal Pharmacology
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Author : Timothy S. Gaginella
language : en
Publisher: CRC Press
Release Date : 1995-10-20
Handbook Of Methods In Gastrointestinal Pharmacology written by Timothy S. Gaginella and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-20 with Medical categories.
Gastroenterology has advanced through the development and application of increasingly sophisticated methods to measure changes in gastrointestinal function. Handbook of Methods in Gastrointestinal Pharmacology brings together details on commonly employed approaches in investigative gastroenterology. The book provides comprehensive coverage of methods and techniques used to investigate the mechanism of action of drugs on the GI tract. An integral part of each chapter is the discussion of development of techniques based upon physiologic mechanisms and principles in pharmacology. In vivo and in situ techniques involving whole animals, isolated tissue methodology, the use of single cell systems, and molecular biology approaches are covered. Illustrations provide a clear understanding of methodologies discussed. Emphasis is placed on advantages and disadvantages of each technique in answering specific research questions. Chapters are written by experts experienced in the techniques they discuss; many pioneered one or more widely used methods. The wide variety of topics included make the Handbook of Methods in Gastrointestinal Pharmacology useful to established investigators, research fellows, and graduate students. Additionally, reviewers of grants and manuscripts can use it to clarify questions that arise regarding appropriate use of a technique in a particular setting.
Receptor Biology
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Author : Michael S. Roberts
language : en
Publisher: John Wiley & Sons
Release Date : 2016-05-02
Receptor Biology written by Michael S. Roberts and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-02 with Science categories.
Dieses verständlich geschriebene Lehrbuch ist nicht nur hoch informativ, sondern macht die komplexe Thematik der Signalwege von Rezeptoren leichter greifbar. Es eignet sich perfekt für Kurse zu diesem Fachgebiet in den Studiengängen Biologie, Medizin oder Pharmakologie.
Therapeutic Monoclonal Antibodies
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Author : Zhiqiang An
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20
Therapeutic Monoclonal Antibodies written by Zhiqiang An and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Science categories.
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Textbook Of Receptor Pharmacology
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Author : John C. Foreman
language : en
Publisher: CRC Press
Release Date : 2010-09-10
Textbook Of Receptor Pharmacology written by John C. Foreman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-10 with Medical categories.
For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from a renowned course on receptor pharmacology, this text presents in-depth coverage of this rapidly expanding research area. The book combines current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms. It focuses on molecular investigation of receptor structure, quantitative functional studies of agonists and antagonists, ligand binding, and signal transduction at the cell membrane. This edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions.