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Cellular And Molecular Aspects Of Inflammation


Cellular And Molecular Aspects Of Inflammation
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Cellular And Molecular Aspects Of Inflammation


Cellular And Molecular Aspects Of Inflammation
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Author : George Poste
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Cellular And Molecular Aspects Of Inflammation written by George Poste and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.


The characterization of the cellular and molecular mechanisms that mediate inflammation provides a foundation that supports future studies that will de fine mechanisms more intimately. It encourages substantial optimism about the opportunities to understand the inflammatory process and to use that information to develop novel therapeutic approaches. Recent progress has defined the cells that mediate the inflammatory response, many of the inter cellular transmitters, the receptors, signal transduction processes and regula tory mechanisms. Thus, we now have the opportunity to understand inflammation in pharmacologic terms and to attack the key molecular targets to develop new therapeutics. Among the cells involved in the inflammatory response are the lympho cytes, neutrophils and endothelial cells. Maintenance of homeostasis, re sponse to proinflammatory stimuli and pathophysiologic responses are products of complex interactions between these and other elements of the immune systems. Each of these cells displays a variety of receptors to define the stimuli to which they respond. The receptors displayed that the signal transduction processes and cellular responses are regulated genetically and epigenetic ally . The critical role of membranes and particularly the phospho lipid components of the membranes is emphasized by recent studies.



Molecular And Cellular Basis Of Inflammation


Molecular And Cellular Basis Of Inflammation
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Author : Charles N. Serhan
language : en
Publisher: Springer Science & Business Media
Release Date : 1998-12-09

Molecular And Cellular Basis Of Inflammation written by Charles N. Serhan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-12-09 with Medical categories.


The study of inflammation has captured the interest of scholars since the earliest recorded history. Symbols identifying the cardinal signs of inflammation were uncovered in both Sanskrit and hieroglyphics (1). Since complete apprecia tion of the inflammatory process is underscored by the need for knowledge at both the cellular and molecular levels, academic inquiry in the area of inflammation has led, in many respects, the foray of current biomedical research. Molecular and Cellular Basis of Inflammation represents research from the cutting edge in the broad view of inflammation. The chapters are written by experts with a multidisciplinary approach to the study of inflammatory and cellular processes, and thus include contributions form the fields of molecular biology, biochemistry, pharmacology, immunology, and pathobiology. Molecular and Cellular Basis of Inflammation was first conceived during a mini symposium sponsored by the American Society for Investigative Pathology held at FASEB in 1995 entitled "The Role of Reactive Lipids, Oxygen and Nitro gen Metabolites in Inflammation," at which several of the contributing authors delivered lectures. This present, much-extended volume includes leading-front descriptions of both protein and lipid mediators. The chapter devoted to the comple ment cascade by Ward and colleagues, as well as Chapters 3-7 and 13, provide up to-date descriptions of the biosynthesis, molecular biology, chemistry, and actions of both protein and lipid mediators.



Inflammation 4 Volume Set


Inflammation 4 Volume Set
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Author : Jean-Marc Cavaillon
language : en
Publisher: John Wiley & Sons
Release Date : 2018-02-20

Inflammation 4 Volume Set written by Jean-Marc Cavaillon and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-20 with Medical categories.


The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.



Molecular Aspects Of Inflammation


Molecular Aspects Of Inflammation
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Author : Helmut Sies
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Molecular Aspects Of Inflammation written by Helmut Sies and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.


Understanding the molecular basis of complex biological processes has been amajor goal of biological chemistry from early on. Inflammation is such one entitiy, and recent years have seen exciting progress in the understanding of molecuar interactions; there has been a long way from dolor, rubor, calor and tumor as a fundamental description of the phenomenon tocurrent knowlegde on e.g. the control of the respiratory burst of the granulocyte, the atomic details of protease regulation, or the interaction of cytokines. The book is organized in the order of increasing complexity, starting out with the key phenomena of the inflammatory response and its modulation by cytokines to intravascular events and shock and sepsis; thus, the current attemptsto apply basic knowledge on mediators of inflam- mation to the clinical situation were also considered.



Inflammation Fundamental Mechanisms


Inflammation Fundamental Mechanisms
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Author : Ley Klaus
language : en
Publisher: World Scientific
Release Date : 2018-03-13

Inflammation Fundamental Mechanisms written by Ley Klaus and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-13 with Medical categories.


Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation. Contents: TNF Superfamily in Inflammation (Marisol Veny, Richard Virgen-Slane and Carl F Ware) Complement as a Mediator of Inflammation (B Paul Morgan) Lipids and Inflammation (Valerie B O'Donnell, Robert C Murphy and Garret A FitzGerald) Reactive Oxygen Species (Ulla G Knaus) Leukocyte Adhesion (Klaus Ley and Zhichao Fan) Neutrophil Extracellular Traps (Tobias A Fuchs, Abdul Hakkim and Constantin F Urban) Sepsis (Jamison J Grailer, Matthew J Delano and Peter A Ward) Granulomatous Inflammation (Marc Hilhorst, Gene Hunder, Jörg Goronzy and Cornelia Weyand) Readership: Graduate students, medical doctors/ practitioners, researchers, pathologists and nutritionists in medicine and healthcare. Keywords: Cytokines;IL-1;TNF;Lipid Mediators;Bradykinin and Neuropeptides;Leukocyte Adhesion;Angiogenesis;Degranulation;Antimicrobial Peptides;Neutrophil Extracellular Traps (NETs);Pharmacologic Modulation of Inflammation;Sepsis;Complement;Oxygen Radicals;Reperfusion Injury;Resolution of Inflammation;Atherosclerosis;Granulomatous Inflammation;Inflammatory Bowel DiseaseReview: Key Features: Up-to-date resource Comprehensive review of the various facets of inflammation



Cellular And Molecular Mechanisms Of Inflammation


Cellular And Molecular Mechanisms Of Inflammation
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Author : Charles G. Cochrane
language : en
Publisher: Academic Press
Release Date : 2013-10-22

Cellular And Molecular Mechanisms Of Inflammation written by Charles G. Cochrane and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.


Cellular and Molecular Mechanisms of Inflammation: Signal Transduction in Inflammatory Cells, Part A is a collection of papers that discusses the mechanisms of the transduction of signals linking stimulated receptors and cellular function. This book describes the pathways of signal transduction involved in stimulating functions of inflammatory cells connected with host defense and development of inflammatory injury. One paper notes the potential of using fluorescence methodology in analyzing ligand-receptor interactions in living systems during the natural abundance of cell surface receptors. Another paper discusses the structure and function of GTP-binding proteins in neutrophil signal transduction, particularly the role of oligomeric G proteins in signal transduction. One concern in signal transduction research is the physiological significance of the presence of multiple forms of proteins that can have identical functions. One paper reviews phosphatidylcholine breakdown and hormone action in the rat liver, focusing on G proteins and on inositol phospholipid breakdown. This book also discusses calcium translocation in signal transduction, as well as, a novel signal transduction pathway involving phosphatidylinositol 3-kinase. This book can prove beneficial for biochemists, micro-biologists, cellular researchers, and academicians involved in the study of cellular biology, physiology or oncology.



Cellular And Molecular Mechanisms Of Inflammation


Cellular And Molecular Mechanisms Of Inflammation
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Author : Charles G. Cochrane
language : en
Publisher:
Release Date : 1990

Cellular And Molecular Mechanisms Of Inflammation written by Charles G. Cochrane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with categories.




Cellular And Molecular Mechanisms Of Inflammation


Cellular And Molecular Mechanisms Of Inflammation
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Author : Charles G. Cochrane
language : en
Publisher: Academic Press
Release Date : 2013-10-22

Cellular And Molecular Mechanisms Of Inflammation written by Charles G. Cochrane and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Health & Fitness categories.


Receptors of Inflammatory Cells: Structure-Function Relationships is the first in a new serial on Cellular and Molecular Mechanisms of Inflammation. The purpose of this serial is to bring together the latest knowledge in various areas of research in this actively developing field around a topical focus. These volumes are not intended to present comprehensive reviews. Rather, each contribution is meant to be a status report from laboratories actively working in an area. This volume presents an analysis of the structure-function relationships of receptors. It is clear that the structure of receptors provides the initial guidance for numerous functions of each cell in the organism. Through an analysis of the submolecular features of the receptors that are responsible for the initiation of activity of diverse biochemical pathways within the cells, a molecular understanding of the all important initial, guiding events of cell functions will emerge. In the broad sense of cells involved in inflammation, this includes mitogenesis, gene transcription, generation of lipid metabolites and oxidants, clearance of molecules from the surrounding medium, and release of granular constituents from cytoplasmic vesicles into the external medium, among others. The contents of this first volume will serve as a foundation for the subject of the second volume, which is signal transduction. Four additional volumes are in preparation, including Endothelial Leukocyte-Adhesion Molecules, Leukocyte Adhesive Mechanisms in Inflammation and Immunity, a second volume on Signal Transduction, and Stimulation of Inflammatory Cells.



Cellular Molecular Mechanisms Of Inflammation


Cellular Molecular Mechanisms Of Inflammation
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Author : Charles G. Cochrane
language : en
Publisher:
Release Date : 1999

Cellular Molecular Mechanisms Of Inflammation written by Charles G. Cochrane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.




Biochemistry Of Inflammation


Biochemistry Of Inflammation
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Author : J. Whicher
language : en
Publisher: Springer Science & Business Media
Release Date : 1992-02-29

Biochemistry Of Inflammation written by J. Whicher and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-02-29 with Medical categories.


Our understanding of inflammation has increased rapidly in recent years, due in large part to the impact of molecular biology and gene identification and cloning. This book brings together ideas from a number of different biochemical disciplines which are frequently not integrated. The first chapter gives a visual overview of the subject; the remaining chapters are organized into three themes: the affector molecules, the regulatory components and the processes of inflammation itself. This book is essential reading for the busy physician or pathologist who wants to be up-to-date with the latest developments in immunology as they affect the diagnosis and treatment of many conditions.