Cellular In Vitro Testing

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Cellular In Vitro Testing

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Author : John Haycock
language : en
Publisher: CRC Press
Release Date : 2014-08-27

Cellular In Vitro Testing written by John Haycock and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-27 with Medical categories.

Growing cells in 2D under static conditions has long been the gold standard of cell culture, despite this method not being representative of the complex in vivo environment. The use of animal models also has clear ethical and scientific limitations, and increasingly the 3Rs (replacement, refinement, reduction) in relation to animal models are being

In Vitro Methods In Pharmaceutical Research

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Author : Jose V. Castell
language : en
Publisher: Elsevier
Release Date : 1996-10-04

In Vitro Methods In Pharmaceutical Research written by Jose V. Castell and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-10-04 with Medical categories.

In Vitro Methods in Pharmaceutical Research provides a comprehensive guide to laboratory techniques for evaluating in vitro organ toxicity using cellular models. Step-by-step practical tips on how to perform and interpret assays for drug metabolism and toxicity assessment are provided, along with a comparison of different techniques available. It is a welcome addition to the literature at a time when interest is growing in cellular in vitro models for toxicology and pharmacology studies. - Meets the continuing demand for information in this field - Compares In Vitro techniques with other methods - Describes cell-culture methods used to investigate toxicity in cells derived from different organs - Includes contributions by leading experts in the field

Dietary Supplements

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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2005-01-03

Dietary Supplements written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-03 with Medical categories.

The growing consumer interest in health and fitness has expanded the market for a wide range of products, from yoga mats to the multiple dietary supplements now on the market. Supplements are popular, but are they safe? Many dietary supplements are probably safe when used as recommended. However, since 1994 when Congress decided that they should be regulated as if they were foods, they are assumed to be safe unless the Food and Drug Administration can demonstrate that they pose a significant risk to the consumer. But there are many types of products that qualify as dietary supplements, and the distinctions can become muddled and vague. Manufacturers are not legally required to provide specific information about safety before marketing their products. And the sales of supplements have been steadily increasingâ€"all together, the various types now bring in almost $16 billion per year. Given these confounding factors, what kind of information can the Food and Drug Administration use to effectively regulate dietary supplements? This book provides a framework for evaluating dietary supplement safety and protecting the health of consumers.

Cellular Response To Biomaterials

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Author : Lucy Di Silvio
language : en
Publisher: Elsevier
Release Date : 2008-12-22

Cellular Response To Biomaterials written by Lucy Di Silvio and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-22 with Technology & Engineering categories.

The response of cells to biomaterials is critical in medical devices. Traditionally inert biomaterials were used to minimise the reaction in cells in contact with the material. However, it has been realised that specific cell responses may be beneficial in such areas as encouraging adhesion, healing or cell multiplication. Cellular response to biomaterials discusses the response of cells to a wide range of biomaterials targeted at specific medical applications.Part one discusses cell responses to a variety of polymers and ceramics with chapters on such topics as degradable polymers and biocompatibility. Part two covers cell responses and regenerative medicine with coverage of themes such as vascular grafts, nerve repair and Bioglass®. Part three examines the effect of surfaces and proteins on cell response. Specific chapters review nano-engineered surfaces, the influence of plasma proteins on bone cell adhesion and surface modification of titanium implants.With its distinguished editor and team of international contributors, Cellular response to biomaterials is an essential read for those researching or studying medical devices in industry and academia. - Examines the response of cells to a wide range of biomaterials targeted at specific medical applications - Discusses cell responses and regenerative medicine with specific chapters on vascular grafts and nerve repair - Assesses the effect of surfaces and proteins on cell response including the influence of plasma proteins on cell adhesion and surface modification of titanium implants

Cell Culture Models Of Biological Barriers

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Author : Claus-Michael Lehr
language : en
Publisher: CRC Press
Release Date : 2002-08-08

Cell Culture Models Of Biological Barriers written by Claus-Michael Lehr and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-08-08 with Medical categories.

Over the past ten years several sophisticated in vitro test systems based on epithelial cell cultures have been introduced in the field of drug delivery. These models have been found to be very useful in characterizing the permeability of drugs across epithelial tissues, and in studying formulations or carrier systems for improved drug delivery and

Drug Testing In Vitro

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Author : Uwe Marx
language : en
Publisher: John Wiley & Sons
Release Date : 2007-02-27

Drug Testing In Vitro written by Uwe Marx and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-27 with Science categories.

Here, expert scientists from industry and academia share their knowledge on the assembly of functional human tissues in vitro and how to design drug screenings predictive of human exposure. In so doing, they combine the latest technological developments with strategic outlooks, such as novel cell and tissue systems for drug screening and testing, as well as emerging in vitro culture technologies. Equally importantly, the book does not shy away from regulatory acceptance and ethical issues.

Cell Culture Test Methods

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Author :
language : en
Publisher: ASTM International
Release Date :

Cell Culture Test Methods written by and has been published by ASTM International this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Veterinary Toxicology

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Author : Ramesh C Gupta
language : en
Publisher: Elsevier
Release Date : 2011-04-28

Veterinary Toxicology written by Ramesh C Gupta and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-28 with Medical categories.

Veterinary Toxicology, 2nd edition is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This reference book is thoroughly updated with new chapters and the latest coverage of topics that are essential to research veterinary toxicologists, students, professors, clinicians and environmentalists. Key areas include melamine and cyanuric acid, toxicogenomics, veterinary medical geology, toxic gases, toxicity and safety evaluation of new veterinary pharmaceuticals and much more. The 2nd edition of this popular book represents the collective wisdom of leading contributors worldwide and continues to fill an undeniable need in the literature relating to veterinary toxicology. - New chapters covering important and timely topics such as melamine and cyanuric acid, toxicogenomics, toxic gases and veterinary medical geology - Expanded look at international topics, such as epidemiology of animal poisonings, regulatory guidelines and poisonous plants in Europe - Heavily contributed book with chapters written by qualified and well-experienced authorities across all areas of veterinary toxicology - Problem solving strategies are offered for treatment as well as in-depth knowledge of the basic mechanisms of veterinary toxicology

Cell Culture Test Methods

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Author : S. A. Brown
language : en
Publisher: ASTM International
Release Date : 1983

Cell Culture Test Methods written by S. A. Brown and has been published by ASTM International this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Science categories.

Drug Absorption Studies

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Author : Carsten Ehrhardt
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-22

Drug Absorption Studies written by Carsten Ehrhardt and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-22 with Medical categories.

This is a well thought-out, highly practical text covering contemporary ‘in vitro’ techniques for drug absorption studies. Starting at the molecular level of investigation, it continues with cell monolayer models (both primary and cell lines) and culminates with in situ techniques as a final testing format. In addition, chapters on high-throughput assays, in vitro-in vivo correlation, bioinformatics and regulatory issues are covered, giving a comprehensive overview of available models and techniques. Moreover, an appendix consisting of a number of practical protocols is available online, updated as needed, and should prove very helpful to apply the techniques directly to the benchside.