Cellular Transplantation
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Cellular Transplantation
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Author : Craig Halberstadt
language : en
Publisher: Elsevier
Release Date : 2011-10-10
Cellular Transplantation written by Craig Halberstadt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.
There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. Provides detailed description of clinical trials in cell transplantation Review of current therapeutic approaches Coverage of the broad range of diseases addressed by cell therapeutics Discussion of stem cell biology and its role in transplantation
Handbook Of Stem Cell Transplantation And Cellular Therapy Management
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Author : Edwin P. Alyea, III, MD
language : en
Publisher: Springer Publishing Company
Release Date : 2020-09-29
Handbook Of Stem Cell Transplantation And Cellular Therapy Management written by Edwin P. Alyea, III, MD and has been published by Springer Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-29 with Medical categories.
Handbook of Stem Cell Transplantation and Cellular Therapy Management provides an evidence-based practical guide for clinicians and practitioners who treat cancer patients with these challenging and innovative techniques. The handbook begins with chapters on autologous transplantation for myeloma and lymphoma and allogenic transplantation for leukemia, lymphoma, and myelodysplastic syndrome. Further chapters cover the standards of care for managing adverse events related to acute graft-versus-host disease, chronic graft-versus-host disease, infections of bacterial, fungal, and viral nature, lymphoproliferative disease, pulmonary complications, renal complications, and more clinical issues. Concluding chapters address new CAR T-cell therapies, including their mechanisms of action, indications, and unique associated toxicities, in addition to a chapter dedicated to biostatistics and clinical trials. Throughout the book, extensive tables, flow diagrams, and other figures highlight, simplify, and illustrate key concepts. Written by experienced clinicians at the world-renowned Dana Farber Cancer Center and Harvard Medical School in Boston as well as leading experts at other institutions, this stem cell transplantation handbook combines the clinical knowledge, expertise and practical application of these potential life-saving cell therapies in one quick, point-of-care reference. With real-world clinical vignettes interwoven among the chapters, this handbook is an essential resource for anyone managing patients being treated with stem cell transplantation or cellular therapies. Key Features: Provides latest insights and recommendations for managing challenging treatment complications and adverse events Consolidates key information such as diagnosis criteria, disease staging, common complications, and more using detailed tables and diagrams Shares real-world clinical vignette examples, which provide insight into clinical assessment, treatment, and management Emphasizes patient management and best practices Discusses short- and long-term risks for stem cell transplantation and cellular therapy
Hematopoietic Stem Cell Transplantation And Cellular Therapies For Autoimmune Diseases
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Author : Richard K. Burt
language : en
Publisher: CRC Press
Release Date : 2021-11-17
Hematopoietic Stem Cell Transplantation And Cellular Therapies For Autoimmune Diseases written by Richard K. Burt and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-17 with Medical categories.
This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight
Quality Management And Accreditation In Hematopoietic Stem Cell Transplantation And Cellular Therapy
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Author : Mahmoud Aljurf
language : en
Publisher: Springer Nature
Release Date : 2021-02-19
Quality Management And Accreditation In Hematopoietic Stem Cell Transplantation And Cellular Therapy written by Mahmoud Aljurf and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-19 with Medical categories.
This open access book provides a concise yet comprehensive overview on how to build a quality management program for hematopoietic stem cell transplantation (HSCT) and cellular therapy. The text reviews all the essential steps and elements necessary for establishing a quality management program and achieving accreditation in HSCT and cellular therapy. Specific areas of focus include document development and implementation, audits and validation, performance measurement, writing a quality management plan, the accreditation process, data management, and maintaining a quality management program. Written by experts in the field, Quality Management and Accreditation in Hematopoietic Stem Cell Transplantation and Cellular Therapy: A Practical Guide is a valuable resource for physicians, healthcare professionals, and laboratory staff involved in the creation and maintenance of a state-of-the-art HSCT and cellular therapy program.
Cellular Therapies Past Present And Future
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Author : Anne Dickinson
language : en
Publisher: Frontiers Media SA
Release Date : 2018-10-18
Cellular Therapies Past Present And Future written by Anne Dickinson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-18 with Science categories.
Haematopoietic stem cell transplantation was initiated in the early 1970’s by pioneers studying radiation-induced bone marrow damage and blood transfusion. Since that time there have been over one million transplants and over 34 million donors registered with the world marrow donor association. This special edition of Frontiers in Immunology highlights the research achievements which led to the curative therapy of haematopoietic stem cell transplantation (HSCT) but also reviews the ongoing complications such as graft versus host disease (GvHD) and infection caused by the procedure. Early animal and human studies are reviewed as well as those which led to the development of changes in transplant protocols such as peripheral blood stem cell and cord blood transplants and the harnessing of graft versus leukaemia (GvL) effects by donor lymphocyte infusions. The eBook covers immunogenetics, the role of biomarkers, and future developments of the therapy which will aim to further improve the outcome for HSCT patients. The eBook is divided into 8 chapters dealing with animal studies; a history of early human studies; the pathophysiology of HSCT; graft versus host disease; graft versus leukaemia effects; immune reconstitution; non-HLA immunogenetics and future developments, including use of mesenchymal stem cells, virus specific T cells and chimeric antigen receptor (CAR) therapy.
Best Practices In Processing And Storage For Hematopoietic Cell Transplantation
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Author : Joseph Schwartz
language : en
Publisher: Springer
Release Date : 2017-12-05
Best Practices In Processing And Storage For Hematopoietic Cell Transplantation written by Joseph Schwartz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-05 with Medical categories.
This concise book examines clinically relevant issues relating to the ways in which bone marrow, cord blood and apheresis products, are processed and stored for the purpose of Hematopoietic Cell Transplantation and Cell Therapy. The twin aims are to offer up-to-date content covering a wide spectrum of topics and controversies and to provide practitioners in the field of transplant and cell therapy with practical, immediately applicable information from the internationally experts in the field. Each chapter focuses on a particular subject, and numerous working tables, algorithms, and figures are included. Whenever appropriate, the reader’s attention is drawn to the availability of potentially high-impact clinical trials and expert practices. The authors are all experts who have been carefully selected for their knowledge of the topics that they address. The book will appeal to clinical and laboratory personnels, residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant products and patients. Its format ensures that it will also serve as a robust, engaging tool to aid vital activities in every hematology and oncology trainee’s daily work.
Stem Cell Transplantation And Tissue Engineering
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Author : A. Haverich
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Stem Cell Transplantation And Tissue Engineering written by A. Haverich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
As dogmas in stem cell research are losing their impact and recent findings regarding the use and cultivation of stem cells and tissue transplantation have opened up new therapeutic avenues, this Ernst Schering Research Foundation Workshop was initiated to highlight current and future approaches in this field. The only stem cells that have been used clinically for a long time is the hematopoietic stem cell as a source for bone marrow transplantation. Recent findings now indicate that hematopoietic stem cells, under certain conditions, are able to differentiate into endothelial, neural or muscle cells, providing exciting new therapeutic possibilities. They represent a future source for tissue engineering replacing defective cells or tissues and allowing diseased organs to regain their functions. Both reconstitution techniques are paving the way for the development of new therapeutic strategies, giving hope of being able to cure and not only treat patients.
Living Donor Transplantation
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Author : Henkie P. Tan
language : en
Publisher: CRC Press
Release Date : 2007-04-27
Living Donor Transplantation written by Henkie P. Tan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-27 with Medical categories.
Edited by leaders at one of the acclaimed transplant institutions in the United States, this reference covers all aspects of living donor solid organ and cellular transplantation in current clinical practice, including the kidney, liver, pancreas, lung, small bowel, islet, and hematopoietic stem cell transplantation. Detailed, engaging, and organ-
The Bmt Data Book
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Author : Reinhold Munker
language : en
Publisher: Cambridge University Press
Release Date : 2013-02-21
The Bmt Data Book written by Reinhold Munker and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-21 with Medical categories.
This is an essential guide to the data, basic science, outcome studies and decision-making processes involved in blood and marrow stem cell transplantation. Organized according to disease types and procedures, it contains more than 100 tables, figures and algorithms that reflect up-to-date research and give guidance on the choices between different types of chemotherapy, autologous vs. allogeneic transplantation, peripheral blood vs. bone marrow stem cells, and standard vs. experimental treatments. This new edition summarizes the research of the last four years and gives mature data for all established indications, such as acute myeloid leukemia, myelodysplastic syndrome and Hodgkin and non-Hodgkin lymphomas. New chapters discuss global trends in stem cell transplantation, cellular therapies including donor lymphocytes, and pediatric neurologic and metabolic disorders. With an expanded complications section, links to electronic databases and discussion of new drugs and alternative stem cell sources, this text belongs in every transplant unit.
Manual Of Hematopoietic Cell Transplantation And Cellular Therapies E Book
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Author : Qaiser Bashir
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-12-23
Manual Of Hematopoietic Cell Transplantation And Cellular Therapies E Book written by Qaiser Bashir and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-23 with Medical categories.
Led by authors from MD Anderson’s Stem Cell Transplantation and Cellular Therapy Department, the world’s largest and highly respected program at the forefront of rapidly advancing treatments in the field, Manual of Hematopoietic Cell Transplantation and Cellular Therapies is a comprehensive, focused reference covering the latest clinical developments and applications of stem cell transplant and cellular therapies for hematologic malignancies and solid tumors. This cutting-edge title, with a majority contribution from the MD Anderson Cancer Center and leading faculty from other academic institutions, covers breakthrough cell-based therapies for various diseases including lymphoma, multiple myeloma, leukemia, and select solid tumor and autoimmune diseases. This unique, definitive resource is essential for hematologists, fellows in hematology and immunotherapy, mid-level providers, pharmacists, and oncologists who refer patients for cell-based therapies. Addresses hematologic conditions including leukemia, lymphoma, and myeloma. Offers guidance on hematopoietic cell transplantation for solid tumors. Covers basic science principles, clinical aspects, pharmacology, radiation therapy, and disease-specific guidelines, including prevention and management of complications. Discusses key topics such as hematopoietic cell collection, bone marrow harvesting, umbilical cord blood transplantation, CAR T-cell therapy, and patient/donor selection and preparation of HCT. Features extensive summary boxes, bulleted content, and algorithms throughout for quick and easy reference. Offers team-based, clinically-focused coverage from world-renowned leaders in the field.