Cerebral Amyloid Angiopathy In Alzheimer S Disease And Related Disorders
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Cerebral Amyloid Angiopathy In Alzheimer S Disease And Related Disorders
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Author : M.M. Verbeek
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Cerebral Amyloid Angiopathy In Alzheimer S Disease And Related Disorders written by M.M. Verbeek and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).
Cerebrovascular Pathology In Alzheimer S Disease
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Author : Jack C. De La Torre
language : en
Publisher:
Release Date : 1997
Cerebrovascular Pathology In Alzheimer S Disease written by Jack C. De La Torre and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Family & Relationships categories.
Do changes in the cerebrovascular system precede or follow clinical onset of Alzheimer's Disease? In this book a distinguished group of contributors addressES this question and explores the extent to which the pathological changes found in the brains of persons with Alzheimer's disease are related to cerebral blood flow, perfusion, and blood-brain barrier dysfunction. Other topics include the role of stroke, heart disease, diabetes, menopause, and blood pressure on the evolution of Alzheimer's disease; genetic factors affecting the cerebrovasculature; brain metabolic and chronic cerebral hypoperfusion; and the influence of the cerebromicrovasculature on neuronal function--all issues of critical importance in orienting research lines that may provide new answers to the Alzheimer puzzle.
Neurodegeneration
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Author : Dennis Dickson
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-09
Neurodegeneration written by Dennis Dickson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-09 with Medical categories.
Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, α-synuclein and TDP-43) and in the extracellular compartments (e.g. β-amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay-out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up-to-date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.
Oxford Textbook Of Cognitive Neurology And Dementia
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Author : Masud Husain
language : en
Publisher: Oxford University Press
Release Date : 2018-10-29
Oxford Textbook Of Cognitive Neurology And Dementia written by Masud Husain and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-29 with Clinical neuropsychology categories.
This volume covers the dramatic developments that have occurred in basic neuroscience and clinical research in cognitive neurology and dementia. It is based on the clinical approach to the patient, and provides essential knowledge that is fundamental to clinical practice.
Cerebral Microbleeds
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Author : David J. Werring
language : en
Publisher: Cambridge University Press
Release Date : 2011-05-26
Cerebral Microbleeds written by David J. Werring and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-05-26 with Medical categories.
Stroke is a leading cause of death and disability throughout the world. About one in three symptomatic strokes are due to disease of small perforating arteries; however, most effective interventions are targeted at disease of large arteries. The underlying mechanisms and treatment of small vessel disease remain poorly understood. Microbleeds have emerged as a critical imaging marker of small vessel disease, being found in all types of stroke. With increasing evidence that microbleeds are caused by hypertensive arteriopathy and cerebral amyloid angiopathy, they are likely to play a strong future role in increasing our understanding of the causes of small vessel disease and the potential link between cerebrovascular disease and neurodegeneration. Cerebral Microbleeds summarizes our current knowledge, bringing together expert research from global authorities in the field. This authoritative and systematic text will be of interest to all clinical researchers and physicians in the fields of stroke and cognitive impairment.
Amyloid Beta Clearance In Alzheimer S Disease
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Author : Robert Marr
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-24
Amyloid Beta Clearance In Alzheimer S Disease written by Robert Marr and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-24 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
Vascular Factors In Alzheimer S Disease
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Author : Raj N. Kalaria
language : en
Publisher:
Release Date : 2000
Vascular Factors In Alzheimer S Disease written by Raj N. Kalaria and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Alzheimer's disease categories.
Vascular factors - including cerebral abnormalities, cardiovascular pathophysiology, and genetic influences - are rapidly gaining importance in the cause and progression of Alzheimer's disease, cerebral amyloid angiopathy, and other vascular dementias. This text, taken from a conference, addresses several important epidemiologic, pathologic, and clinical issues in establishing the role of vascular pathogensis of these debilitating disorders, including a review of collinergic and other molecular mechanisms, white matter lesioins, the roles of apolipoprotein E, and genetics. The presenters also offer new approaches to diagnostic, preventive and treatment strategies for the caregivers of a patient populations that is increasing with an aging population.
Cerebral Small Vessel Disease And Cerebral Amyloid Angiopathy
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Author : Raffaella Valenti
language : en
Publisher: Firenze University Press
Release Date : 2018
Cerebral Small Vessel Disease And Cerebral Amyloid Angiopathy written by Raffaella Valenti and has been published by Firenze University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Type 2 Diabetes And Dementia
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Author : Velandai Srikanth
language : en
Publisher: Academic Press
Release Date : 2018-02-09
Type 2 Diabetes And Dementia written by Velandai Srikanth and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-09 with Medical categories.
Type 2 Diabetes and Dementia details the relationship between diabetes, dementia and the future of medicine and therapeutics. Chapters range from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment and prevention strategies, and the application of therapeutics. The book reflects the translational aspects of the current science in the field, with an emphasis on the display of neuroimaging and neuropathology. It contains contributions from world experts, and is ideal for clinicians and researchers in the fields of neurology, neuroscience, geriatric medicine and endocrinology. Presents a comprehensive overview that details the relationship between diabetes, dementia and the future of medicine and therapeutics Written for researchers and clinicians in neurology, neuroscience, geriatric medicine and endocrinology Includes topics ranging from epidemiology, clinical features, neuroimaging biomarkers, neuropathology, macrostructural and molecular mechanisms, risk assessment, prevention strategies and therapeutic applications
Uncommon Causes Of Stroke
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Author : Julien Bogousslavsky
language : en
Publisher: Cambridge University Press
Release Date : 2001-05-24
Uncommon Causes Of Stroke written by Julien Bogousslavsky and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-05-24 with Medical categories.
An essential resource for diagnosis and treatment of stroke patients outside the usual clinical categories.
