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Cerebrospinal Fluid Biomarkers

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Cerebrospinal Fluid Biomarkers

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Author : Charlotte E. Teunissen
language : en
Publisher: Humana
Release Date : 2021-06-06

Cerebrospinal Fluid Biomarkers written by Charlotte E. Teunissen and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-06 with Medical categories.

This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.

Cerebrospinal Fluid In Neurologic Disorders

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Author :
language : en
Publisher: Elsevier
Release Date : 2017-11-17

Cerebrospinal Fluid In Neurologic Disorders written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-17 with Medical categories.

Cerebrospinal Fluid in Neurologic Disorders, Volume 146 provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker. The second part addresses the main purpose of the volume, describing CSF from a research perspective in context with the most important diagnostic entities in neurology. The book's authors provide insight into the current understanding of CSF changes in these various conditions and what it tells us about the nature of neurological diseases. Furthermore, methodological aspects are discussed, as are shortcomings that need to be addressed. Finally, the book provides an outlook for potential directions that can be explored to improve the various aspects of CSF research with the ultimate goal of being incorporated in clinical practice. Provides a brief overview on the current use of CSF in clinical routine, the physiology of CSF, and its usefulness and potential as a biomarker Addresses relevant research in context with the most important diagnostic entities in neurology Edited by leading authors in CSF research from around the globe, presenting the broadest, most expert coverage available

Biomarkers In Alzheimer S Disease

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Author : Tapan Khan
language : en
Publisher: Academic Press
Release Date : 2016-08-02

Biomarkers In Alzheimer S Disease written by Tapan Khan and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-02 with Science categories.

Biomarkers in Alzheimer’s Disease provides a comprehensive overview of all modalities of Alzheimer’s disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer’s disease and technological advancement of biomarkers techniques. The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer’s disease, and for differential diagnosis of Alzheimer’s disease with other non-Alzheimer’s dementia. Presents a comprehensive overview detailing all modalities of Alzheimer’s disease biomarkers Written for neuroscience researchers and clinicians studying or treating patients with Alzheimer’s Disease Integrates, in each chapter, the molecular/cellular abnormality due to Alzheimer’s disease and the technological advancement of biomarkers techniques

Cerebrospinal Fluid Biomarkers In Alzheimer S Disease

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Author : Ross William Paterson
language : en
Publisher:
Release Date : 2016

Cerebrospinal Fluid Biomarkers In Alzheimer S Disease written by Ross William Paterson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.

Cerebrospinal Fluid In Clinical Neurology

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Author : Florian Deisenhammer
language : en
Publisher: Springer
Release Date : 2015-02-05

Cerebrospinal Fluid In Clinical Neurology written by Florian Deisenhammer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-05 with Medical categories.

The cerebrospinal fluid (CSF) is an invaluable diagnostic tool in clinical neurology, not only in the evaluation of inflammatory, degenerative, and malignant diseases of the nervous system, but also in the diagnosis of all forms of cerebral and subarachnoidal bleedings. The CSF can be easily obtained by lumbar puncture and a set of basic analyses can be conducted using relatively simple laboratory methods. By combining different CSF parameters, a wide range of diagnostic entities can be identified. However, properly interpreting the test results requires a high level of expertise and cannot be achieved by just reporting on individual analytic values. This book covers essential aspects of cerebrospinal fluid analysis and its use in the diagnosis of common neurological diseases. The first part addresses preclinical aspects such as the history of CSF, as well as the anatomical, physiological, and biological background of this valuable fluid. In addition, CSF collection, its preanalytical and methodological implications, and the increasing number of disease-specific markers in CSF are discussed in detail. Lastly, CSF analyses are put into context with clinical syndromes, demonstrating their diagnostic value in neurological clinical practice. Cerebrospinal Fluid in Clinical Neurology helps readers understand the preanalytical and analytical aspects of CSF diagnostics and offers a valuable reference guide for interpreting CSF results during the clinical work-up for neurological patients.

Cerebrospinal Fluid

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Author : Lawrence E. Keen
language : en
Publisher: Nova Science Publishers
Release Date : 2014

Cerebrospinal Fluid written by Lawrence E. Keen and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Biochemical markers categories.

The cerebrospinal fluid (CSF) is a dynamic, metabolically active fluid that occupies the subarachnoid space and the ventricular system around the brain, and has many important functions. CSF is a promising body fluid for the search of biomarkers associated with neurological disease, because the CSF has more physical contact with brain than any other fluids, biochemical changes related to many pathology may be reflected in the CSF. Although CSF is obtained by lumbar puncture, invasive and potentially painful for the patient, it is probably the most informative fluid in biomarkers discovery for neurological disease prognosis. This book discusses CSF biomarkers; novel developed biomarkers in neurological diseases; CSF biochemical markers of cerebral metabolism in dogs; and guidance for the selection and interpretation of laboratory tests.

Cerebrospinal Fluid Biomarkers For The Study Of The Pathophysiological Pathways In Alzheimer S Disease

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Author : Daniel A. Alcolea Rodríguez
language : en
Publisher:
Release Date : 2015

Cerebrospinal Fluid Biomarkers For The Study Of The Pathophysiological Pathways In Alzheimer S Disease written by Daniel A. Alcolea Rodríguez and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.

Esta tesis profundiza en el conocimiento de las enfermedades neurodegenerativas y, concretamente, en la enfermedad de Alzheimer tanto en sus fases sintomáticas como en la etapa preclínica (antes de que se manifiesten los síntomas). Esto es posible a través del estudio de biomarcadores en líquido cefalorraquídeo, que reflejan in vivo los cambios que tienen lugar en el cerebro desde fases muy iniciales de la enfermedad y que son el hilo argumental de esta tesis doctoral. A modo de introducción, el capítulo 1 define el marco y el contexto general de esta tesis resumiendo el conocimiento acerca de la enfermedad de Alzheimer y los biomarcadores. En el capítulo 2 estudiamos la viabilidad de la punción lumbar, la incidencia de complicaciones relacionadas con esta técnica y los factores que se asocian con ellas con el fin de determinar el impacto de este procedimiento para el estudio de biomarcadores de líquido cefalorraquídeo en las enfermedades neurodegenerativas. En el capítulo 3, se analizan las diferencias patofisiológicas entre la enfermedad de Alzheimer esporádica y familiar. El estudio de biomarcadores en líquido cefalorraquídeo nos permite identificar in vivo algunas características que complementan la información sobre el procesamiento de la proteína precursora de amiloide obtenida en el estudio neuropatológico. En el capítulo 4 profundizamos en las diferencias en biomarcadores en líquido cefalorraquídeo entre distintas enfermedades neurodegenerativas que cursan con demencia en sus fases sintomáticas, y estudiamos la relación entre biomarcadores involucrados en distintos procesos fisiopatológicos. La extensión de este estudio a las fases preclínicas conforman el capítulo 5. Para ello, analizamos el mismo conjunto de biomarcadores en una extensa cohorte de participantes sin déficits cognitivos. El capítulo 6 analiza la relación entre uno estos biomarcadores, YKL-40, y el grosor cortical medido por resonancia magnética en las fases predemencia de la enfermedad de Alzheimer. Finalente, en el capítulo 7 se pone en perspectiva todo lo expuesto para argumentar las conclusiones finales y formular las futuras líneas de investigación derivadas de estos proyectos. En resumen, en esta tesis doctoral utilizamos los biomarcadores en líquido cefalorraquídeo para estudiar la enfermedad de Alzheimer des de un punto de vista traslacional en todas sus fases (clínica y preclínica), y para establecer relaciones entre diferentes procesos fisiopatológicos. Este tipo de abordaje es esencial para obtener herramientas de diagnóstico más precisas, profundizar en el conocimiento de los procesos que tienen lugar en fases iniciales de la enfermedad y, potencialmente, identificar nuevas dianas terapéuticas.