Challenges And Channels
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Targeting Ion Channels For Drug Discovery Emerging Challenges For High Throughput Screening Technologies
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Author : Ciria Hernandez
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-07
Targeting Ion Channels For Drug Discovery Emerging Challenges For High Throughput Screening Technologies written by Ciria Hernandez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-07 with Science categories.
Ligand and voltage-gated ion channels are highly regulated protein molecules that cross the cell membrane allowing ion flow from one side of the membrane to the other. They are ubiquitously expressed in human tissues and consist of one of the largest and best understood functional groups of proteins, with more than 400 members spanning nearly 1% of the human genome. They are involved in a variety of fundamental physiological processes, and their malfunction causes numerous diseases. In terms of the challenges faced in the effort to discover specific drugs in ancient and emerging diseases, ion channels are the third-largest class of target proteins after G-protein-coupled receptors (GPCRs) and kinases. 15% of small molecule drug targets have been reported to be voltage- or ligand-gated ion channels, resulting in approximately 150 new drug candidates in preclinical and clinical studies. Of the ion channel targeting drugs found on the market, these were identified more than a decade ago, and many of the current studies are at various stages of scientific approval. Overcoming these challenges has led the field of ion channel drug discovery to transform over the past 15 years through major advancements in genetic target detection, validation, structure-based drug design, and drug modeling of cell-based diseases.
The Channel Conundrum
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Author : Dr. Govind Rao
language : en
Publisher: Notion Press
Release Date : 2024-07-27
The Channel Conundrum written by Dr. Govind Rao and has been published by Notion Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-27 with Business & Economics categories.
In today's fiercely competitive landscape, mastering channel management is crucial for organizational growth. "The Channel Conundrum" emerges as an indispensable guide, delving into the complexities of effective channel management. This comprehensive volume seamlessly blends theoretical insights with real-world case studies and actionable strategies, equipping readers with the tools to navigate the intricate web of distribution channels. The book commences by introducing fundamental concepts and the significance of channel management. It explores key components of channel strategy development, including market segmentation, partner selection, and performance measurement. Subsequent chapters delve into the art of developing robust channel partner programs, offering insights into aligning programs with business objectives, creating structured partner tiers, and fostering collaborative relationships. A key strength of "The Channel Conundrum" lies in its pragmatic approach to navigating channel conflicts. It provides a comprehensive framework for understanding conflict root causes and proven resolution strategies. The book explores managing power dynamics, aligning incentives, and fostering trust among channel partners. In an era of rapid technological change, the book takes a forward-looking approach, exploring digital technologies' transformative impact on channel management. It equips readers with the knowledge to leverage distribution channels as strategic assets for growth and competitive advantage, making it an invaluable resource for practitioners, executives, and scholars alike.
Getting Multi Channel Distribution Right
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Author : Kusum L. Ailawadi
language : en
Publisher: John Wiley & Sons
Release Date : 2020-04-14
Getting Multi Channel Distribution Right written by Kusum L. Ailawadi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-14 with Business & Economics categories.
Getting Multi-Channel Distribution Right provides a comprehensive treatment of modern distribution strategy that is analytically solid, clearly written, and relevant for managers as well as MBA and executive MBA students, and the professors who train them. It covers concepts, metrics, tools, and strategic frameworks for managing distribution in physical and digital channels. Focusing on the challenges of managing multiple channels of distribution in an evolving marketplace—rather than the process of designing a distribution channel from scratch—it leans more heavily on metrics and tools and incorporates perspectives from academic research, as well as in-depth case studies from marketing and general management practice. Introduces an organizing framework of pull and push marketing for how suppliers work together with their channel partners. Integrates across physical and digital, independent and company-owned, routes to market. Maps the functions of traditional and newer intermediaries in the channel ecosystem and identifies the root causes of conflict between them. Provides tools and frameworks for how much distribution coverage is required and where. Shows how product line, pricing, trade promotions, and other channel incentives can help to coordinate multiple channels and manage conflict. Illustrates how push and pull metrics can be combined into valuable dashboards for identifying positive feedback opportunities and sustaining the channel partnership. With the help of Getting Multi-Channel Distribution Right you’ll discover how to successfully develop, execute, and adapt distribution strategy to the evolving marketplace.
Handbook Of Research On Distribution Channels
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Author : Charles A. Ingene
language : en
Publisher: Edward Elgar Publishing
Release Date : 2019
Handbook Of Research On Distribution Channels written by Charles A. Ingene and has been published by Edward Elgar Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Business & Economics categories.
Distribution channels are the most complex element of the marketing mix to fully grasp and to profitably manage. In this Handbook the authors present cutting-edge research on channel management and design from analytical, conceptual, and empirical perspectives. The breadth of this Handbook makes it appropriate for use in a doctoral course on distribution channels, or as a knowledge-broadening resource for faculty and researchers who wish to understand types of channels research that are outside the scope of their own approach to distribution.
Handbook Of Research On Interdisciplinary Perspectives On The Threats And Impacts Of Pandemics
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Author : Omeraki Çekirdekci, Şahver
language : en
Publisher: IGI Global
Release Date : 2021-11-26
Handbook Of Research On Interdisciplinary Perspectives On The Threats And Impacts Of Pandemics written by Omeraki Çekirdekci, Şahver and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-26 with Social Science categories.
The COVID-19 pandemic shook the world to its core. After a brief pause, organizations of all kinds had to adapt to the new circumstances given to them with very little time. The presence of the pandemic caused multiple threats that caused several disruptions to the norms, beliefs, and practices in various domains of everyday life. Both from macro and micro perspectives, individuals, households, markets, institutions, and governments developed strategies to respond to the new environment—responses that hope to eliminate or at least decrease the threats of the COVID-19 pandemic. The Handbook of Research on Interdisciplinary Perspectives on the Threats and Impacts of Pandemics explores the COVID-19 pandemic from an interdisciplinary perspective and determines how future pandemics may impact society. Beginning as a health threat, the pandemic has led the way to economic, social, psychological, political, and informational crises necessitating the examination of the phenomenon from different academic disciplines. Covering topics such as distance education, human security, and predictions, this handbook of research is an essential resource for scholars, managers, media representatives, governors, health officials, government officials, policymakers, students, professors, researchers, and academicians.
Trp Channels As Therapeutic Targets
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Author : Arpad Szallasi
language : en
Publisher: Elsevier
Release Date : 2024-08-22
Trp Channels As Therapeutic Targets written by Arpad Szallasi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-22 with Medical categories.
TRP Channels as Therapeutic Targets, Second Edition is a comprehensive reference on the roles of TRP Channels in health and disease states. The Editor lined up a team of worldwide experts in academia and corporate R&D to provide diverse views into these promising drug development targets. Following the research development happened in the past ten years, since the first edition published, the revision includes seven new chapters. All remaining chapters are completely updated. New topics included in the book are TRP channels biology, the crystalline structure of TRP channels, targeting TRP channels for pain relief, the relationship with migraine, emerging pain targets, a comprehensive view of the role of TRP channels in respiratory diseases and COVID complications, anxiety relief, renal disease, arthritis, and therapeutic opportunities for thermal regulation. TRP Channels as Therapeutic Targets, Second Edition is a reference for broad segments of the scientific and medical community. Researchers working on TRP channel drug discovery will benefit from the overview of applications to conditions in specific organ systems. Clinicians interested in new drugs in the pipeline, will find in this book their biologic principles of action. - Presents the perspectives of several life science research specialties on the topic - Provides a comprehensive picture of the TRP field, from TRP channel dysfunction through TRP drug discovery and development to clinical trials and everyday medical practice - Represents an updated and complete reference
Knowledge Preservation And Curation
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Author : Margie Foster
language : en
Publisher: Emerald Group Publishing
Release Date : 2023-12-01
Knowledge Preservation And Curation written by Margie Foster and has been published by Emerald Group Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-01 with Business & Economics categories.
In order to achieve its full value, knowledge must flow and be continuously used. Knowledge use, reuse, and repurposing has been a challenge discussed in knowledge sciences literature for over three decades. The authors investigate and offer solutions to two key challenges - how to preserve and curate knowledge.
Customer Relationship Management
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Author : V. Kumar
language : en
Publisher: Springer
Release Date : 2018-05-15
Customer Relationship Management written by V. Kumar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-15 with Business & Economics categories.
This book presents an extensive discussion of the strategic and tactical aspects of customer relationship management as we know it today. It helps readers obtain a comprehensive grasp of CRM strategy, concepts and tools and provides all the necessary steps in managing profitable customer relationships. Throughout, the book stresses a clear understanding of economic customer value as the guiding concept for marketing decisions. Exhaustive case studies, mini cases and real-world illustrations under the title “CRM at Work” all ensure that the material is both highly accessible and applicable, and help to address key managerial issues, stimulate thinking, and encourage problem solving. The book is a comprehensive and up-to-date learning companion for advanced undergraduate students, master's degree students, and executives who want a detailed and conceptually sound insight into the field of CRM. The new edition provides an updated perspective on the latest research results and incorporates the impact of the digital transformation on the CRM domain.
The Multichannel Challenge
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Author : Hugh Wilson
language : en
Publisher: Routledge
Release Date : 2008
The Multichannel Challenge written by Hugh Wilson and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Business & Economics categories.
While innovation in products and services continues apace, today's competitive strategy is equally based on innovation in the route to market. Tesco.com, Direct Line, First Direct and easyJet are just a few examples of innovative channel strategies as a key component of the value proposition. We find ourselves in a multi-channel world. This book is drawn from the experience of major companies such as IBM, First Direct, Taylor Woodrow and BT. Lessons are explained clearly: be Multi not multiple; channels as weapons; think combinations; design from the top, but think people and measure it. The key concepts are backed by carefully tested practical advice from making organisational change to understanding channel metrics. Based on work from Cranfield's world leading Customer Management Forum, this is the essential practical guide for senior management in key areas like marketing, sales, customer services and strategy.
How To Build A Profitable Youtube Channel
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Author : Kalpit Chaddha
language : en
Publisher: Kalpit Chaddha
Release Date : 2023-03-10
How To Build A Profitable Youtube Channel written by Kalpit Chaddha and has been published by Kalpit Chaddha this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-10 with Computers categories.
Are you looking to turn your passion for creating content into a successful and profitable career on YouTube? Look no further than 'How to Build a Profitable YouTube Channel.' In this comprehensive guide, author and successful YouTuber shares their proven strategies for growing your audience, maximizing your revenue streams, and creating a sustainable business around your channel. From crafting engaging content and optimizing your videos for search, to building a strong brand and working with sponsors, this book covers all the essential steps to creating a successful YouTube channel. With practical tips and real-world examples, 'How to Build a Profitable YouTube Channel' is the ultimate guide for anyone looking to turn their YouTube dreams into a reality. Whether you're a beginner just starting out or a seasoned creator looking to take your channel to the next level, this book is the blueprint for success on the world's largest video-sharing platform.