Challenges Associated With Identifying Preclinical Animal Models For The Development Of Immune Based Therapies

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Challenges Associated With Identifying Preclinical Animal Models For The Development Of Immune Based Therapies

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Author : Rajan P. Adhikari
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-24

Challenges Associated With Identifying Preclinical Animal Models For The Development Of Immune Based Therapies written by Rajan P. Adhikari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-24 with Medical categories.

There hasn’t been a better time to be a drug developer for immune-based therapies than the past couple of decades. We have seen an explosion in immune-based therapies for cancer, autoimmune and infectious diseases, metabolic diseases and diseases and disorders of the nervous system. The modalities of these immune-based therapies span small molecules, biologics, and gene and cell therapeutic approaches. Significant advances have been made in optimizing drug design for its specificity for the target, characterizing the mode of action in in vitro assays, and ensuring safety and manufacturability. However, an area of challenge that remains is identifying animal models for evaluating efficacy and pharmacokinetics/pharmacodynamics relationship that are predictive of drug effects in humans. Discussion on this topic is warranted as examples of failures of translation from animal models to humans provide us an opportunity to learn more about human biology.

Policy Issues In The Clinical Development And Use Of Immunotherapy For Cancer Treatment

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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2016-12-10

Policy Issues In The Clinical Development And Use Of Immunotherapy For Cancer Treatment written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-10 with Medical categories.

Immunotherapy is a form of cancer therapy that harnesses the body's immune system to destroy cancer cells. In recent years, immunotherapies have been developed for several cancers, including advanced melanoma, lung cancer, and kidney cancer. In some patients with metastatic cancers who have not responded well to other treatments, immunotherapy treatment has resulted in complete and durable responses. Given these promising findings, it is hoped that continued immunotherapy research and development will produce better cancer treatments that improve patient outcomes. With this promise, however, there is also recognition that the clinical and biological landscape for immunotherapies is novel and not yet well understood. For example, adverse events with immunotherapy treatment are quite different from those experienced with other types of cancer therapy. Similarly, immunotherapy dosing, therapeutic responses, and response time lines are also markedly different from other cancer therapies. To examine these challenges and explore strategies to overcome them, the National Academies of Sciences, Engineering, and Medicine held a workshop in February and March of 2016. This report summarizes the presentations and discussions from the workshop.

Patient Derived Tumor Xenograft Models

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Author : Rajesh Uthamanthil
language : en
Publisher: Academic Press
Release Date : 2016-10-13

Patient Derived Tumor Xenograft Models written by Rajesh Uthamanthil and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-13 with Medical categories.

Patient Derived Tumor Xenograft Models: Promise, Potential and Practice offers guidance on how to conduct PDX modeling and trials, including how to know when these models are appropriate for use, and how the data should be interpreted through the selection of immunodeficient strains. In addition, proper methodologies suitable for growing different type of tumors, acquisition of pathology, genomic and other data about the tumor, potential pitfalls, and confounding background pathologies that occur in these models are also included, as is a discussion of the facilities and infrastructure required to operate a PDX laboratory. - Offers guidance on data interpretation and regulatory aspects - Provides useful techniques and strategies for working with PDX models - Includes practical tools and potential pitfalls for best practices - Compiles all knowledge of PDX models research in one resource - Presents the results of first ever global survey on standards of PDX development and usage in academia and industry

Animal Models In Cancer Drug Discovery

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Author : Asfar Azmi
language : en
Publisher: Academic Press
Release Date : 2019-04-16

Animal Models In Cancer Drug Discovery written by Asfar Azmi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-16 with Science categories.

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. - Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover - Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas - Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 2006

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Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
language : en
Publisher:
Release Date : 2005

Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 2006 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with United States categories.

Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas

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Author : Giuseppe Orlando
language : en
Publisher: Academic Press
Release Date : 2019-11-10

Transplantation Bioengineering And Regeneration Of The Endocrine Pancreas written by Giuseppe Orlando and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-10 with Science categories.

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 2, sets a new standard in transplant and regenerative medicine. The book details the state-of-the-art in modern islet auto-transplantation, also discussing current progress in regenerative medicine research in diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, hence this volume catalogs technologies being developed and methods being implemented. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology and developmental biology are all addressed and applied directly to diabetes medicine. - Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation - Addresses imaging, treatment, scaffold technology, the use of stem cells to generate insulin, 3D printing, and more - Offers an update on the progress of regenerative medicine research aimed at beta cell replacement for the treatment of diabetes

Novel Concepts In Using Broadly Neutralizing Antibodies For Hiv 1 Treatment And Prevention

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Author : Philipp Schommers
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-09

Novel Concepts In Using Broadly Neutralizing Antibodies For Hiv 1 Treatment And Prevention written by Philipp Schommers and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-09 with Medical categories.

Current Research On Pre Clinical Aspects Of Cancer Therapy

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Author : Current Cancer Research Project Analysis Center (U.S.)
language : en
Publisher:
Release Date : 1975

Current Research On Pre Clinical Aspects Of Cancer Therapy written by Current Cancer Research Project Analysis Center (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Cancer categories.

1038 references to research projects being conducted in the United States and elsewhere. Entries arranged under 5 topics, e.g., Preclinical studies of anticancer drugs, Preclinical radiation therapy, and Preclinical immunotherapy. Entriesinclude title, researcher, address, contract number, summary, and supporting agency. Indexes by subjects, investigators, contractors, supporting agencies, and contractor numbers.

Protac Mediated Protein Degradation A Paradigm Shift In Cancer Therapeutics

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Author : Mukesh Nandave
language : en
Publisher: Springer Nature
Release Date : 2024-08-31

Protac Mediated Protein Degradation A Paradigm Shift In Cancer Therapeutics written by Mukesh Nandave and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-31 with Science categories.

This book is a comprehensive coverage of the ubiquitin-proteasome system and its involvement in cancer progression, and the application of PROTACs in different types of cancer treatment. The book discusses a unique perspective and comprehensive knowledge of the potential of PROTACs to transform cancer therapies. It provides an overview of the history, mechanisms, chemistry, design considerations, and different technologies involved in PROTACs. Additionally, it explains the ubiquitin-proteasome system, its impact on various diseases, and the principles and mechanisms of UPS. The book also describes the chemistry and design aspects of PROTACs and their role in various types of cancers. Finally, it covers the pharmaceutics aspect of formulation design, global requirements, and toxicological aspects of PROTACs. This book is targeted at cancer researchers, medical oncologists, bioinformatics, computational biologists, pharmacologists, medicinal chemists, formulation scientists, regulatory authorities, and policy makers.

Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 1996

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Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
language : en
Publisher:
Release Date : 1995

Departments Of Labor Health And Human Services Education And Related Agencies Appropriations For 1996 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with United States categories.