Characterization Of Elastic Fiber Assembly

DOWNLOAD

Download Characterization Of Elastic Fiber Assembly PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Characterization Of Elastic Fiber Assembly book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Characterization Of Elastic Fiber Assembly

DOWNLOAD
Author : Beth Ann Kozel
language : en
Publisher:
Release Date : 2004

Characterization Of Elastic Fiber Assembly written by Beth Ann Kozel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.

Analysis Of Elastic Fiber Assembly And Ultrastructure With Respect To Dosage Levels Of Fibulin 4

DOWNLOAD
Author : Léa-Jeanne Ringuette
language : en
Publisher:
Release Date : 2015

Analysis Of Elastic Fiber Assembly And Ultrastructure With Respect To Dosage Levels Of Fibulin 4 written by Léa-Jeanne Ringuette and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.

"Fibulin-4 belongs to the fibulin family of extracellular matrix proteins, consisting of seven known members and characterized by tandem repeats of calcium-binding epidermal growth factor (cbEGF)-like motifs and a C-terminal fibulin module. Fibulin-4 knockout (-/-) mice die perinatally due to aortic rupture. Electron microscopic investigation of the aortic wall shows severe disruption of the formation of the elastic laminae and little association of the elastic fibers with the vascular smooth muscle cell surface. In humans, genetic mutations in the fibulin-4 gene have been identified in two cutis laxa (loose skin) patients, both of which exhibited aortic aneurysms. In this study, the effect of the dosage of fibulin-4 was investigated with available mouse models. Using fibulin-4 heterozygous (+/-) and knockout (-/-) mice, as well as, fibulin-4 knockdown (+/R and R/R) mice, with reduced levels of fibulin-4, electron microscopic analyses of the aortic wall were conducted. Our results indicate that reduced levels of fibulin-4 lead to elastic fiber and collagen fibril abnormalities. Although a significant amount of elastin is produced in mice with low levels of fibulin-4, the elastic laminae that are formed show a lace-like appearance. Both +/R and R/R mice also show large, irregular collagen fibrils in the aorta, suggesting that fibulin-4 plays an important role in the regulation of collagen fibril diameter. This is a novel finding. In addition, a stoichiometric relationship between fibulin-4 and fibulin-5 was investigated using two available mouse models, Fbln4SMKO: Fbln5+/- and Fbln4SMKO: Fbln5-/-; electron microscopy of the aortic wall was conducted. These mice harbor a reduction in fibulin-4 that is specific to the blood vessels. It was demonstrated that the absence of fibulin-5 in the Fbln4SMKO: Fbln5-/- mice, the lace-like appearance of the elastic laminae was improved. Taken together, these results indicate that a stoichiometric relationship between fibulin-4 and fibulin-5 exist during elastic fiber assembly. " --

Fibrous Assemblies From Synthesis And Nanostructure Characterization To Materials Development And Application

DOWNLOAD
Author : Cinzia Giannini
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-01

Fibrous Assemblies From Synthesis And Nanostructure Characterization To Materials Development And Application written by Cinzia Giannini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-01 with Science categories.

Mechanics Of Flexible Fibre Assemblies

DOWNLOAD
Author : J. W. S. Hearle
language : en
Publisher: Springer
Release Date : 1980-07-31

Mechanics Of Flexible Fibre Assemblies written by J. W. S. Hearle and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980-07-31 with Technology & Engineering categories.

Continued and systematic analysis of the mechanics of flexible fibre assemblies dates from about 1945, although the growth of research into textiles after 1920 had included studies of fabric structure and the measurement of mechanical properties. The subject is thus a young one, although this NATO Advanced Study Institute is a sign of developing maturity. However there is an earlier tradition. Relevant, even if somewhat loosely connected, quotations can be found in the works of the engineers of the ancient civilisations, recurring during the llenaissance with Leonardo da Vinci and Galileo. But the glorious libk is with Euler and the Bernoulli family, with their theories of the mechanics of flexible slender rods. While mathematicians have admired the beauty of this work, the invention of elliptic integrals, and the grace of the different classes of planar elastica, it is in the technology of textile materials, composed of flexible fibres and yarns, that the subject has found its more direct application. All this, and much more such as Max Born's doctoral thesis, was brought to our attention in a delightful discourse by Milos Konopasek, who is not only fascinated by the mathematics of Euler and the modern movement of the solutions of bending curves from two dimensions into three by the use of the computer, but also feels a personal link through having lived and studied within sight of the scene of Euler's triumphs in St. Petersburg.

Self Assembly And Fibre Formation Of Elastin Llke Polypeptides

DOWNLOAD
Author : Judith Cirulis
language : en
Publisher:
Release Date :

Self Assembly And Fibre Formation Of Elastin Llke Polypeptides written by Judith Cirulis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Self Assembly And Fibre Formation Of Elastin Like Polypeptides

DOWNLOAD
Author : Judith Tamara Cirulis
language : en
Publisher:
Release Date : 2009

Self Assembly And Fibre Formation Of Elastin Like Polypeptides written by Judith Tamara Cirulis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.

Elastin is a polymeric protein of the extracellular matrix that imparts the characteristics of extensibility and elastic recoil to tissues. Recombinant polypeptides based on the domain structures and sequences of human elastin self-assemble into organized fibrous structures, with physical properties similar to those of native polymeric elastin. Elastin self-assembly is initiated by a temperature-induced phase separation, called coacervation. Previous to this work, coacervation temperature had been the only parameter available to measure propensity for self-assembly. A variety of techniques were developed using spectrophotometry, microscopy, and rheometry to differentiate the stages of self-assembly, thereby enabling independent observation and quantitation of each stage, and allowing investigations into properties of polypeptides and solution conditions affecting these stages.Self-assembly in the presence of non-elastin, matrix-associated proteins showed that these proteins maintained the coacervate as small droplets, which sometimes flocculated into fibre-like structures. Rheometry demonstrated a second temperature-induced transition above the coacervation temperature, which resulted in gelation and viscoelastic characteristics similar to microgels.Kinetic analysis of self-assembly yielded two additional parameters: coacervation velocity and maturation velocity. Examining the effects of agitation, salt concentration, temperature, polypeptide concentration, size of a polypeptide, hydrophobic domain sequence, and cross-linking domain structure on the kinetics demonstrated that coacervation and maturation are independent stages of self-assembly involving distinct mechanisms. Microscopic observations showed that protein-rich droplets of coacervate grew by coalescence to a stable droplet size, which correlated to differences in maturation velocities between polypeptides. Coacervate droplet growth appeared limited by the formation of organized polypeptide at the surface of the droplets, decreasing surface fluidity. Many of the general principles of the physical chemistry of colloids and emulsions appeared to apply to the formation, growth and stabilization of coacervates of the elastin-like polypeptides.Together, these observations have resulted in a greater level of understanding of the entire self-assembly process, and provided a comprehensive model of elastin-like polypeptide self-assembly that relates to in vivo assembly of elastic fibres.

Extracellular Matrix Assembly And Structure

DOWNLOAD
Author : Peter D. Yurchenco
language : en
Publisher: Academic Press
Release Date : 2013-10-22

Extracellular Matrix Assembly And Structure written by Peter D. Yurchenco and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Science categories.

The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling

Cell Biology Of Extracellular Matrix

DOWNLOAD
Author : E.D. Hay
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11

Cell Biology Of Extracellular Matrix written by E.D. Hay and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.

In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Elastic Fiber Matrices

DOWNLOAD
Author : Anand Ramamurthi
language : en
Publisher: CRC Press
Release Date : 2018-09-03

Elastic Fiber Matrices written by Anand Ramamurthi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Medical categories.

Elastic Fiber Matrices: Biomimetic Approaches to Regeneration and Repair provides a comprehensive resource on the intrinsic and pathological aberrations of the complex process of elastic matrix assembly and/or variations thereof in different elastic tissue types, and on strategies to regenerate or restore lost elastin matrix, either in vitro or in vivo, including biomimetic elastin-like-peptides, gene therapy, drug delivery, tissue engineering (biomolecules, scaffolds, and mechanical stimuli), pharmacological approaches, elastin stabilization and preservation, stem cell therapy, allografts/xenografts, and synthetic/biological elastomers. Comprised of individual chapters contributed by leading researchers and scientists in the field, the text details current approaches for elastin matrix regeneration and repair, identifying their various advantages and limitations while offering valuable insight into emerging trends. Thus, this book is a must-have guide for academicians and industry professionals working in the areas of connective tissue biology, tissue engineering, dermal and cardiovascular biomaterials, and drug delivery.

Handbook Of Fibrous Materials 2 Volumes

DOWNLOAD
Author : Jinlian Hu
language : en
Publisher: John Wiley & Sons
Release Date : 2020-06-22

Handbook Of Fibrous Materials 2 Volumes written by Jinlian Hu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-22 with Technology & Engineering categories.

Edited by a leading expert in the field with contributions from experienced researchers in fibers and textiles, this handbook reviews the current state of fibrous materials and provides a broad overview of their use in research and development. Volume One focuses on the classes of fibers, their production and characterization, while the second volume concentrates on their applications, including emerging ones in the areas of energy, environmental science and healthcare. Unparalleled knowledge of high relevance to academia and industry.