Characterization Of The Innate Immunity Elicited By Vaccination And Its Interactions With Adaptive Immunity Depending On Prime Boost Delay
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Characterization Of The Innate Immunity Elicited By Vaccination And Its Interactions With Adaptive Immunity Depending On Prime Boost Delay
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Author : Jean-Louis Palgen
language : en
Publisher:
Release Date : 2019
Characterization Of The Innate Immunity Elicited By Vaccination And Its Interactions With Adaptive Immunity Depending On Prime Boost Delay written by Jean-Louis Palgen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
Vaccination is one of the best achievements made in public health. However, designing vaccines against complex pathogens is currently challenging. The immune system is indeed uncompletely characterized, despite large amount of accumulated knowledges. A better understanding of vaccine-induced immunity is then required to optimize vaccine design. In particular, while most vaccines require several immunizations to induce a long-lasting adaptive immune memory, little is known on the impact of the delay beween the prime inducing a primary memory and the boost restimulating it to induce a secondary memory. Also, the innate immunity induced by each immunization and shaping the adaptative immunity is poorly characterized in this vaccine context.We studied the innate immune responses in cynomolgus macaques immunized with the modified vaccinia virus Ankara, following an homologous prime-boost vaccination at two months apart. We applied mass cytometry and bioinformatic analyses to characterize the innate response induced by each immunization. We showed that prime and boost vaccination triggered distinct innate responses. Actually, prime induced late phenotypic modifications of innate cells. These phenotypic changes suggest a stronger ability to react to the boost. Moreover, reducing the delay between prime and boost to two weeks impeded the mobilization of these phenotypically modified innate cells, and qualitatively altered humoral response.In conclusion, beyond the early innate responses, these results highlight the late induction by the prime of "likely trained" innate cells. This emerging concept corresponds to the ability of innate cells to display memory features based on epigenetic modifications. This "likely training" occured not only on monocytes and NK cells, but also on dendritic cells and strikingly on neutrophils. It was deeply connected with adaptive immune memory establishment, in a prime-boost delay dependant fashion. These findings contribute to pave the way towards to the rationale design of future vaccines, via vaccine schedule optimization and harnessment of innate training.
Quantification Of Immunological Memory
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Author : Antonella Prisco
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-06
Quantification Of Immunological Memory written by Antonella Prisco and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-06 with Medical categories.
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1998
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Medicine categories.
Index To Theses With Abstracts Accepted For Higher Degrees By The Universities Of Great Britain And Ireland And The Council For National Academic Awards
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Author :
language : en
Publisher:
Release Date : 2006
Index To Theses With Abstracts Accepted For Higher Degrees By The Universities Of Great Britain And Ireland And The Council For National Academic Awards written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Dissertations, Academic categories.
Insights In Infectious Agents And Disease 2022
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Author : Axel Cloeckaert
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-18
Insights In Infectious Agents And Disease 2022 written by Axel Cloeckaert and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-18 with Science categories.
We are now entering the third decade of the 21st Century, and, especially in the last years, the achievements made by scientists in the field of Microbiology have been exceptional, leading to major advancements. Frontiers has organized a series of Research Topics to highlight the latest advancements in science in order to be at the forefront of science in different fields of research. This specific editorial initiative, led by Dr. Axel Cloeckaert is focused on new insights, novel developments, current challenges, latest discoveries, recent advances and future perspectives in the field. The Research Topic solicits brief, forward-looking contributions from the editorial board members that describe the state of the art, outlining recent developments and major achieved accomplishments, future challenges and how to address those challenges to move the field forward. Reviews, Mini-Reviews, Perspectives, and Opinions summarizing the current state and future directions of the field are particularly welcome in this collection.
