Chemistry And Biological Activity Of Steroids
DOWNLOAD
FREE 30 Days
Download Chemistry And Biological Activity Of Steroids PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Chemistry And Biological Activity Of Steroids book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Chemistry And Biological Activity Of Steroids
DOWNLOAD
FREE 30 Days
Author : Jorge António Ribeiro Salvador
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-02-26
Chemistry And Biological Activity Of Steroids written by Jorge António Ribeiro Salvador and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-26 with Science categories.
The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.
Molecular Structure And Biological Activity Of Steroids
DOWNLOAD
FREE 30 Days
Author : Martin Bohl
language : en
Publisher: CRC Press
Release Date : 2018-01-18
Molecular Structure And Biological Activity Of Steroids written by Martin Bohl and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Science categories.
Molecular Structure and Biological Activity of Steroids focuses on the indentification of steroid structural features that control particular biological effects. Steroid geometry plays a critical role in steroid activity; therefore, the results of X-ray crystallographic, NMR spectroscopic, and theoretical studies on structure-activity relationships form an integral part of the book. Well-established observations and proposed models are presented, summarizing knowledge of molecular features (e.g., steroid backbone structures, side-chain constitutions, substitution sites, configurations, hydrogen-bonding patterns) that can affect steroid action. The book also provides overviews about recent progress in various frontier fields of steroid research, including such areas as sex steroids, glucocorticoids, aromatase inhibitors, vitamin D metabolites, brassinosteroids, neuromuscular blocking agents, and cardiotonic steroids. Molecular Structure and Biological Activity of Steroids is a "must-have" resource for biochemists, pharmacologists, endocrinologists, biophysicists, and others actively involved in steroid research.
Steroid Chemistry At A Glance
DOWNLOAD
FREE 30 Days
Author : Daniel Lednicer
language : en
Publisher: John Wiley & Sons
Release Date : 2011-06-20
Steroid Chemistry At A Glance written by Daniel Lednicer and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-20 with Science categories.
The term steroid has become virtually synonymous with drug abuse in sport to the majority of the public. However these steroids - androgens - actually comprise only a single relatively small class of biologically active steroids, and are overshadowed by a large collection of compounds, a sizeable number of which are commercial drugs that share the same structural carbon skeleton. The development of these drugs has led to a large body of organic chemistry often denoted as "Steroid Chemistry". Steroid Chemistry At A Glance provides a concise overview of the main principles and reactions of steroid chemistry. Topics covered include: history, isolation and structure determination of steroids steroid nomenclature and stereochemistry natural sources of steroids synthesis and reactions of aromatic a-ring steroids, androstanes, and pregnanes steroids with a spirolactone at position 17 steroids with hetrocyclic ring A compounds derived from cholesterol Based on the highly successful and student friendly "at a glance" approach, the information is presented in integrated, self contained double page spreads of text and illustrative material. Students of chemistry and pharmacy using Steroid Chemistry at a Glance will find they have a resource with which they can quickly, concisely and confidently acquire, regularly review and revise the basic facts that underpin the properties, synthesis and reactions of this important class of natural products. It will also serve as a handy bench reference for postgraduates and professional chemists.
Steroids
DOWNLOAD
FREE 30 Days
Author : Louis Frederick Fieser
language : en
Publisher:
Release Date : 2013-01
Steroids written by Louis Frederick Fieser and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01 with Alkaloids categories.
Biological Activities Of Steroids In Relation To Cancer
DOWNLOAD
FREE 30 Days
Author : Gregory Pincus
language : en
Publisher: Academic Press
Release Date : 2013-09-17
Biological Activities Of Steroids In Relation To Cancer written by Gregory Pincus and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-17 with Medical categories.
Biological Activities of Steroids in Relation to Cancer covers the proceedings of the conference sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, and the U. S. Department of Health, Education and Welfare. The text focuses on the influence of steroids on medical approaches to the cure of cancer, including steroid chemistry, estrogen metabolism, and mammary cancer. The selection first offers information on steroids growth and cancer, advances in steroid chemistry, and the physiology and pharmacology of steroids affecting tumor growth. Discussions focus on rapid development of mammary cancer, pituitary functions, androgens, estrogens, and progestins. The book also ponders on the binding of steroid hormones by plasma proteins; the effects of steroids on the levels of the plasma 17-hydroxycorticosteroids and the serum protein-bound iodine; and the metabolism of dehydroisoandrosterone. The text evaluates studies on estrogen metabolism, biochemical parameters of estrogen action, and enzymatic transport of hydrogen by estrogenic hormones. The manuscript also elaborates on the fate of steroid estrogens in target tissues, effect of steroids on calcium dynamics, and steroids and experimental mammary cancer. The selection is a valuable source of information for readers interested in the use of steroids in treating cancer.
Steroid Dimers
DOWNLOAD
FREE 30 Days
Author : Professor Satyajit D. Sarker
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-13
Steroid Dimers written by Professor Satyajit D. Sarker and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-13 with Science categories.
Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Steroid Compounds With Potential Biological Activity
DOWNLOAD
FREE 30 Days
Author : Marina Savic
language : en
Publisher: Mdpi AG
Release Date : 2023-12-26
Steroid Compounds With Potential Biological Activity written by Marina Savic and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-26 with Science categories.
Steroids are a large group of compounds whose structure is based on a 17-carbon skeleton, with a specific cyclopentanoperhydrophenanthrene ring system. Natural steroids have been fine-tuned through evolution to build membranes; act as chemical messengers that regulate metabolic, immune and reproductive functions in animals and stimulate the growth of, or otherwise protect, animal organisms. The steroid core represents a suitable motive for structural modifications. Therefore, a large group of semi-synthetic steroid derivatives have occupied the attention of synthetic chemists as well as medicinal chemists due to their potential biological activity, including anticancer, antibacterial, anti-inflammatory and (anti)hormonal activities. This Reprint of the Special Issue of Molecules titled "Steroid Compounds with Potential Biological Activity" is dedicated to both experimental and theoretical studies on steroid chemistry, structural biology, biosynthesis, metabolism, and pharmacology. The Issue focuses on the isolation and synthesis of steroid compounds, diverse in origin, as well as their structural characterization and identification. Published articles and reviews relate to in vitro and in silico studies of the pharmacological properties, molecular biology, biochemistry and structural biology of steroids.
Spectroscopic Data Of Steroid Glycosides
DOWNLOAD
FREE 30 Days
Author : Anwer Basha
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-10
Spectroscopic Data Of Steroid Glycosides written by Anwer Basha and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-10 with Science categories.
Spectroscopic Data of Steroid Glycosides serves as an essential reference guide containing spectroscopic, physical and biological activity data of over 3500 steroid glycosides, offering the structures and the data of the naturally occurring glycosides of steroids. All compounds are arranged according to the structure of the aglycone, and, in its own class, according to the increasing molecular weight, making Spectroscopic Data of Steroid Glycosides extremely useful for the structure elucidation of new natural products, particularly glycosides. Spectroscopic Data of Steroid Glycosides offers a practical desk reference for all scientists and students interested in steroid glycosides and their biological and medicinal importance. The following data of the steroid glycosides, as available in published literature, are included: - Name of the compound, Chemical name of compound and its structure, - Source, name of the genus, species, authors, family of the biological source from which the glycoside has been isolated, - Melting point, - Specific rotation, - Molecule weight, - Molecular formula, - UV spectral data : maxima, e or log e , solvent, - IR peaks in cm-1 with medium in which the spectrum was taken e.g. KBr, nujol, etc, - Proton magnetic resonance (PMR) chemical shifts, multiplicity of the peaks, coupling constants with assignments, - 13C-NMR (CMR) chemical shifts with assignments, - Mass spectral data with the technique used (e.g. Electron Impact (E.I.), Fast Atom Bombardment (FAB), positive ion or negative ion mode or any other technique, - CD or ORD data, - Biological Activity, - Full reference from which data have been taken.
Chemical And Biological Aspects Of Steroid Conjugation
DOWNLOAD
FREE 30 Days
Author : S. Bernstein
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Chemical And Biological Aspects Of Steroid Conjugation written by S. Bernstein and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book represents a collaborative endeavor by a group of investigators to bring together in a single volume a critical discussion of the major facets of our knowledge, ranging from chemical to clinical aspects, of steroid conjugation. However, the important field of bile acid and bile alcohol conjugation has been discussed only superficially since it was decided arbitrarily to be outside the projected scope of the book. The reader is referred to the companion volume of this book, namely Physical Properties of Steroid Conjugates (by Bernstein, Dusza, and Joseph, Springer-Verlag New York 1968), for complemental information on individual conjugates. The Editors wish to thank Miss Elise Kramer for typing assistance. Also we wish to express our deep appreciation and gratitude to Mrs. Dorothy Budd, our copy-editor, and Mr. J. Joseph for their editorial assistance in making this book possible. SEYMOUR BERNSTEIN Pearl River, N. Y. January, 1970 SAMUEL SOLOMON V11 CONTENTS Preface . . . . VII Nomenclature a, Discussion of Nomenclature System x b, Trivial and Systematic Names. x List of Contributors . . . . . . . . Xl Chemistry: Synthesis and Characterization S. BERNSTEIN, 1. P. DUSZA, and J. P. JOSEPH Enzymological Aspects of Steroid Conjugation A. B. Roy . . . . . . . . . . 74 The Hydrolysis of Steroid Conjugates H. L. BRADLOW . . . . . 131 Isolation of Steroid Conjugates P. K. SITTERI. . . . . . . 182 The Biochemistry of the 3P-Hydroxy-Ll5-Steroid Sulfates K. D. ROBERTS and S. LIEBERMAN 219 Formation, Metabolism, and Transport of Estrogen Conjugates E. DICZFALUSY and M. LEVITZ. . . . . . . . . . . . .
Molecular Structure And Biological Activity Of Steroids
DOWNLOAD
FREE 30 Days
Author : Martin Bohl
language : en
Publisher: CRC Press
Release Date : 1992-08-14
Molecular Structure And Biological Activity Of Steroids written by Martin Bohl and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-08-14 with Science categories.
Molecular Structure and Biological Activity of Steroids focuses on the indentification of steroid structural features that control particular biological effects. Steroid geometry plays a critical role in steroid activity; therefore, the results of X-ray crystallographic, NMR spectroscopic, and theoretical studies on structure-activity relationships form an integral part of the book. Well-established observations and proposed models are presented, summarizing knowledge of molecular features (e.g., steroid backbone structures, side-chain constitutions, substitution sites, configurations, hydrogen-bonding patterns) that can affect steroid action. The book also provides overviews about recent progress in various frontier fields of steroid research, including such areas as sex steroids, glucocorticoids, aromatase inhibitors, vitamin D metabolites, brassinosteroids, neuromuscular blocking agents, and cardiotonic steroids. Molecular Structure and Biological Activity of Steroids is a "must-have" resource for biochemists, pharmacologists, endocrinologists, biophysicists, and others actively involved in steroid research.