Chemistry Of Metalloproteins
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Chemistry Of Metalloproteins
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Author : Joseph J. Stephanos
language : en
Publisher: John Wiley & Sons
Release Date : 2014-07-22
Chemistry Of Metalloproteins written by Joseph J. Stephanos and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-22 with Science categories.
Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.
Metalloproteins
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Author : Art E. Cho
language : en
Publisher: CRC Press
Release Date : 2015-04-17
Metalloproteins written by Art E. Cho and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-17 with Science categories.
Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role
Handbook On Metalloproteins
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Author : Ivano Bertini
language : en
Publisher: CRC Press
Release Date : 2001-06-29
Handbook On Metalloproteins written by Ivano Bertini and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06-29 with Medical categories.
This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the commo
Metalloprotein Active Site Assembly
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Author : Michael K. Johnson
language : en
Publisher: John Wiley & Sons
Release Date : 2017-08-14
Metalloprotein Active Site Assembly written by Michael K. Johnson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-14 with Science categories.
Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.
Protein Aggregation In Bacteria
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Author : Silvia Maria Doglia
language : en
Publisher: Wiley
Release Date : 2014-04-14
Protein Aggregation In Bacteria written by Silvia Maria Doglia and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-14 with Science categories.
Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies—and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria Physiological importance and consequences of aggregation for the bacterial cell Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.
Handbook Of Metalloproteins Handbook Of Metalloproteins
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Author : Albrecht Messerschmidt
language : en
Publisher: Wiley-Blackwell
Release Date : 2001
Handbook Of Metalloproteins Handbook Of Metalloproteins written by Albrecht Messerschmidt and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Science categories.
The first two volumes of the "Handbook of Metalloproteins", published in 2001, focused on a number of metals, including iron, nickel, manganese, cobalt, copper and vanadium. Now we are delighted to present volume three which extends the wealth of knowledge and focuses on proteins found in the redox-inactive ions of zinc and calcium. (Midwest).
Metal Sites In Proteins And Models
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Author : H.A.O. Hill
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-04-01
Metal Sites In Proteins And Models written by H.A.O. Hill and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-01 with Science categories.
Biological chemistry is a major frontier of inorganic chemistry. Three special volumes devoted to Metal Sites in Proteins and Models address the questions: how unusual ("entatic") are metal sites in metalloproteins and metalloenzymes compared to those in small coordination complexes? and if they are special, how do polypeptide chains and co-factors control this? The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres. They illustrate in particular how the combined armoury of genetics and structure determination at the molecular level are providing unprecedented new tools for molecular engineering.
Handbook Of Metalloproteins
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Author : Albrecht Messerschmidt
language : en
Publisher: Wiley
Release Date : 2001-08-16
Handbook Of Metalloproteins written by Albrecht Messerschmidt and has been published by Wiley this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-08-16 with Science categories.
"it is a pleasure just to read this handsome and carefully produced work" Angewandte Chemie 2002 "...the Handbook of Metalloproteins is highly recommended as a resource for bioinorganic chemistry. It will have lasting value for researchers in the field..." The Alchemist - Chemweb In recent years, the analysis and classification of metalloproteins at the interface between chemistry and biology has accelerated. Many developments and initiatives have taken place and this two-volume handbook provides a comprehensive, yet focussed, collection of 105 major metalloproteins. Content is presented in both a large format and full colour and covers the most relevant transition metals such as Iron, Nickel, Copper, Cobalt, Molybdenum, Manganese Tungsten and Vanadium. This is the first Handbook of Metalloproteins ever published and is comprised of articles written by renowned experts in the field. It draws together contributions from over two hundred internationally renowned researchers that include: Douglas Rees and Charles Stout as well as Nobel Prize winner Robert Huber. Each contribution is presented in a similar format and shows a ribbon plot of the overall 3D Structure on their first page, a representation of the metal active site and numerous other figures and tables underpinning the remarks. Comparative information is provided on different proteins and every entry has been extensively referenced to current literature. * First comprehensive handbook to cover the major metalloproteins * Presents structural and functional data in an organised manner * Incorporates full-colour representation of molecular structures throughout * Unifies information from molecular biology, enzymology, spectroscopy, biochemistry, chemistry, biophysics, macromolecular crystallography and structural biology * Includes comprehensive sections that cover: Functional Class, Occurrence, Amino Acid Sequence Information, Protein Production, Purification and Molecular Characterisation, Metal Content and Cofactors, Activity Test, Spectroscopy, 3D Structure, Functional Aspects.
Handbook Of Metalloproteins 2 Volume Set Volumes 4 And 5
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Author : Albrecht Messerschmidt
language : en
Publisher: Wiley-Blackwell
Release Date : 2011-04-25
Handbook Of Metalloproteins 2 Volume Set Volumes 4 And 5 written by Albrecht Messerschmidt and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-25 with Science categories.
Highlights the progress made in finding new and exciting metalloproteins 10 years after the original publication of the Handbook of Metalloproteins Volumes 1 & 2, and following publication of Volume 3 in 2004, comes the latest two volumes... Presents detailed descriptions of the most exciting newly discovered metalloproteins, including: New metalloproteins involved in photosynthesis, e.g. photosystem I and II, cytochromes New Copper Metalloproteins involved in the formation of Alzheimer’s disease and are leads to new medication New metalloproteins essential in understanding the function of nerves and muscles Researching the structure and function of metalloproteins is one of the biggest challenges in modern biological chemistry – and several Nobel Prizes have been awarded to research in the field, including to the Co-Editor Robert Huber in 1988. Volumes 4 & 5 help bring together the very latest new and exciting metalloproteins in two volumes to help keep you up-to-date in this continually expanding field, including: New metalloproteins involved in photosynthesis Photosynthesis is vital for life on earth. Contributions on photosystem I and II as well as on cytochrome b6f, which are main components of the oxygenic photosynthetic machinery in plants, algae and cyanobacteria, unravel the role of metals and metal cofactors in this fascinating fundamental process New Copper Metalloproteins The role of copper in connection with the amyloid precursor protein for Alzheimer’s disease New metalloproteins essential in understanding the function of nerves and muscles Contributions on Mg2+, Na+ and K+ channels/transporters have been included to highlight their formidable significance in biological systems. Na+, K+-ATPase is e.g. very abundant in heart muscle tissues and represents the target for drugs against heart insufficiency like digitalis drugs Metalloproteins used in metal ion transport and storage Metal ion transport, storage and incorporation have been deeper considered in a row of new articles. The metal ions include iron, zinc, nickel and copper. Factor VIII Factor VIII is an essential blood clotting factor. Some defects might cause a lack of this factor and result in hemophelia A. The new two volumes contain articles published online in the Handbook of Metalloproteins (HMET) from 2007 – 2010, these cover a wide range of newly discovered and exciting metalloproteins since publication of HMET in 2006. These new additional volumes will provide essential reading to all experienced researchers in bioinorganic chemistry and should give the newcomer a good entry into the field in the following areas: Metalloproteins, Proteins, Proteomics, Coordination Chemistry, Bioinorganic Chemistry, Biochemistry, Drug Development, Enzymology.
Metal Sites In Proteins And Models
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Author : H.A.O. Hill
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-07-27
Metal Sites In Proteins And Models written by H.A.O. Hill and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-27 with Science categories.
Biological chemistry is a major frontier of inorganic chemistry. Three special volumes devoted to Metal Sites in Proteins and Models address the questions: how unusual ("entatic") are metal sites in metalloproteins and metalloenzymes compared to those in small coordination complexes? And if they are special, how do polypeptide chains and co-factors control this? The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres. They illustrate in particular how the combined armoury of genetics and structure determination at the molecular level are providing unprecedented new tools for molecular engineering.