Chimerism And Tolerance

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Chimerism And Tolerance

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Author : Suzanne T. Ildstad
language : en
Publisher: Springer
Release Date : 1995

Chimerism And Tolerance written by Suzanne T. Ildstad and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Chimerism categories.

Chimerism, the co-existence of two or more genetically distinct components within one organism, has existed as a concept for centuries. However, the recognition that bone marrow chimerism confers tolerance for transplanted donor tissues, has occurred only during this century. Bone marrow is the only transplantable graft that is permanently accepted without requirement for antirejection agents to prevent graft rejection. This book is about the various types of tolerance which have been observed in association with chimerism and the mechanism by which this unique process may occur. Contributions from world-recognized experts in the field review the clinical as well as basic science aspects of chimerism and tolerance.

Chimerism And Tolerance

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Author : Suzanne T. Ildstad
language : en
Publisher: R G Landes Company
Release Date : 1995

Chimerism And Tolerance written by Suzanne T. Ildstad and has been published by R G Landes Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Science categories.

This textbook reviews tolerance and chimerism, the admittance of cell populations from more than one zygote. Contributions from fields related to mechanisms of donor-specific hyporeactivity are presented and basic science reviews by clinical observations and application are discussed.

Defining The Barrier Of Split Tolerance In Allogeneic Mixed Chimerism

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Author : David Peter Al-Adra
language : en
Publisher:
Release Date : 2012

Defining The Barrier Of Split Tolerance In Allogeneic Mixed Chimerism written by David Peter Al-Adra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Chimerism categories.

Chimerism

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Author : Nicole L. Draper
language : en
Publisher: Springer
Release Date : 2018-06-21

Chimerism written by Nicole L. Draper and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-21 with Medical categories.

This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome. Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented. Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.

Donor Derived Hematopoietic Stem Cells In Organ Transplantation Chimerism And Tolerance

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Author : Beaune Seminar in Transplant Research
language : en
Publisher:
Release Date : 2003

Donor Derived Hematopoietic Stem Cells In Organ Transplantation Chimerism And Tolerance written by Beaune Seminar in Transplant Research and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.

Induction And Maintenance Of Mixed Chimerism And Permanent Donor Specific Tolerance In A Murine Model

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Author : Melissa van Pel
language : en
Publisher:
Release Date : 2003

Induction And Maintenance Of Mixed Chimerism And Permanent Donor Specific Tolerance In A Murine Model written by Melissa van Pel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.

Induction Of Mixed Chimerism And Transplantation Tolerance In A Murine Model

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Author : Hendrika Marianne de Vries- van der Zwan
language : en
Publisher:
Release Date : 1997

Induction Of Mixed Chimerism And Transplantation Tolerance In A Murine Model written by Hendrika Marianne de Vries- van der Zwan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with categories.

Investigation Into The Hormonal Influence Of Tolerance Mechanisms Following Immunosenescence Thymic Regeneration And Bone Marrow Transplantation

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Author : Katerina Vlahos
language : en
Publisher:
Release Date : 2009

Investigation Into The Hormonal Influence Of Tolerance Mechanisms Following Immunosenescence Thymic Regeneration And Bone Marrow Transplantation written by Katerina Vlahos and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Immunological tolerance categories.

While the integrity of immunological self-tolerance is important for the prevention of autoimmunity, the induction of robust and lifelong donor-specific transplantation tolerance, through mixed host-donor hematopoietic chimerism, is also vital for graft survival. We examined the quantitative correlation between bone marrow (BM) dose and the degree of chimerism establishment and tolerance induction, and to assess whether SSA can influence this in an allogenic bone marrow transplant (BMT) setting. As expected a decline in BM dose led to a correlative decline in the degree of mixed chimerism attained. Nevertheless, we show that all chimeric mice, regardless of the degree of chimerism, are tolerant to both allogeneic and autologous antigens, however react to third party antigens, demonstrating the maintenance of global immune responsiveness. Furthermore, we showed that SSA does not alter the overall proportion of donor chimerism following allogeneic BMT; however, it did increase the number of donor-derived cells in central and peripheral lymphoid organs which may have assisted in the induction of tolerance to donor-type antigens, without perturbing tolerance induction. We conclude that SSA is a useful tool for enhancing the establishment of mixed chimerism and tolerance induction by increasing donor cell engraftment. The wide application of BMT for tolerance establishment depends on the development of less toxic protocols and reliable assays with which to detect the establishment of stable donor-specific tolerance. This thesis provides the foundation for future studies aimed at assessing the effectiveness of SSA for the treatment of immune disorders particularly autoimmune diseases and for the induction of transplant tolerance in BMT protocols using milder pre-conditioning regimens. Such work should lead to the development of more patient/sex steroid specific therapies and clinically applicable methods of establishing chimerism by partial conditioning and even possibly voiding the toxicity of lethal ablation.

Neonatal Tolerance And Donor Cell Chimerism

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Author : Anthony John Cutler
language : en
Publisher:
Release Date : 1996

Neonatal Tolerance And Donor Cell Chimerism written by Anthony John Cutler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with categories.

The Ebmt Handbook

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Author : Nicolaus Kröger
language : en
Publisher:
Release Date : 2020-10-08

The Ebmt Handbook written by Nicolaus Kröger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.

This Open Access edition of the European Society for Blood and Marrow Transplantation (EBMT) handbook addresses the latest developments and innovations in hematopoietic stem cell transplantation and cellular therapy. Consisting of 93 chapters, it has been written by 175 leading experts in the field. Discussing all types of stem cell and bone marrow transplantation, including haplo-identical stem cell and cord blood transplantation, it also covers the indications for transplantation, the management of early and late complications as well as the new and rapidly evolving field of cellular therapies. This book provides an unparalleled description of current practices to enhance readers' knowledge and practice skills. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.