Induction And Maintenance Of Mixed Chimerism And Permanent Donor Specific Tolerance In A Murine Model
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Induction And Maintenance Of Mixed Chimerism And Permanent Donor Specific Tolerance In A Murine Model
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Author : Melissa van Pel
language : en
Publisher:
Release Date : 2003
Induction And Maintenance Of Mixed Chimerism And Permanent Donor Specific Tolerance In A Murine Model written by Melissa van Pel and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Thomas Hematopoietic Cell Transplantation
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Author : Karl G. Blume
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Thomas Hematopoietic Cell Transplantation written by Karl G. Blume and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.
NEW - the leading book in its field now fully updated andrevised! Click here to access two FREE sample chapters! An Essential resource for all hematologists, oncologists,pathologists, pediatricians, immunologists and all othersinterested in this dynamic area of medicine! Why you should buy this book.... Extensive coverage of subject area - from the scientific basisto the view of the future Includes all experimental research and clinicalapplication Combined the knowledge and expertise of over 170 internationalspecialists Clear structure and layout Over 500 illustrations, including a colour plate section Why buy the NEW edition...... New and fully revised to reflect the latest developments inthis fast moving field 10 new chapters, covering some of the latest developments - seebelow for the complete tables of content
Textbook Of Organ Transplantation Set
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Author : Allan D. Kirk
language : en
Publisher: John Wiley & Sons
Release Date : 2014-07-21
Textbook Of Organ Transplantation Set written by Allan D. Kirk and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-21 with Medical categories.
Brought to you by the world’s leading transplantclinicians, Textbook of Organ Transplantation provides acomplete and comprehensive overview of modern transplantation inall its complexity, from basic science to gold-standard surgicaltechniques to post-operative care, and from likely outcomes toconsiderations for transplant program administration, bioethics andhealth policy. Beautifully produced in full color throughout, and with over 600high-quality illustrations, it successfully: Provides a solid overview of what transplantclinicians/surgeons do, and with topics presented in an order thata clinician will encounter them. Presents a holistic look at transplantation, foregrounding theinterrelationships between transplant team members and non-surgicalclinicians in the subspecialties relevant to pre- andpost-operative patient care, such as gastroenterology, nephrology,and cardiology. Offers a focused look at pediatric transplantation, andidentifies the ways in which it significantly differs fromtransplantation in adults. Includes coverage of essential non-clinical topics such astransplant program management and administration; research designand data collection; transplant policy and bioethical issues. Textbook of Organ Transplantation is the market-leadingand definitive transplantation reference work, and essentialreading for all transplant surgeons, transplant clinicians, programadministrators, basic and clinical investigators and any othermembers of the transplantation team responsible for the clinicalmanagement or scientific study of transplant patients.
Kidney Transplantation Bioengineering And Regeneration
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Author : Giuseppe Orlando
language : en
Publisher: Academic Press
Release Date : 2017-06-08
Kidney Transplantation Bioengineering And Regeneration written by Giuseppe Orlando and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-08 with Science categories.
Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 2000
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medicine categories.
Frontiers In Transplantology
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Author : Hesham Abdeldayem
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-09-07
Frontiers In Transplantology written by Hesham Abdeldayem and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-07 with Medical categories.
This book is addressed to researchers, practicing physicians, and surgeons in the field of organ transplantation, as well as the medical students, residents, and fellows. The topics covered include the religious concepts in organ transplantation, embryonic organ transplantation, tolerance, normothermic graft perfusion, pharmacogenetics of immunosuppressors, viral transmission in organ transplantation, pediatric and split-liver transplantation, portopulmonary hypertension, mechanical circulatory support, ex vivo lung perfusion, and ABO-incompatible kidney transplantation.
The Immunological Barriers To Regenerative Medicine
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Author : Paul J. Fairchild
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-17
The Immunological Barriers To Regenerative Medicine written by Paul J. Fairchild and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-17 with Science categories.
This volume offers an analysis of the scale and nature of the immunological issues facing regenerative medicine, drawing on the expertise of laboratories around the world who have taken up the challenge of applying their expertise in immunology to the vagaries of stem cell biology. In Part I, we explore the extent to which the principles of allograft rejection, learned over several decades from our experiences of whole organ transplantation, apply within the unique context of cell replacement therapy. Part II discusses various innovative ways of addressing the issues of immunogenicity, while, in Part III, we focus exclusively on the induction of immunological tolerance through a variety of novel approaches. It is our hope that this systematic analysis of the current state of the field will galvanise efforts to solve an issue which has so far remained intractable.
The Journal Of Immunology
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Author :
language : en
Publisher:
Release Date : 2008
The Journal Of Immunology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Immunology categories.
Thomas Hematopoietic Cell Transplantation
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Author : Frederick R. Appelbaum
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-26
Thomas Hematopoietic Cell Transplantation written by Frederick R. Appelbaum and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-26 with Medical categories.
This outstanding reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over 500 illustrations, including a colour plate section. The need for this new edition cannot be overstated - more than 13,000 new cases per year of haematopoietic stem cell transplantation have been reported to the International Bone Marrow Transplant Registry The original editor, Donnall Thomas, was a pioneer in stem cell research and won the 1990 Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases. The book also now includes a fully searchable CD with PDFs of the entire content.
Allorecognition By Leukocytes Of The Adaptive Immune System
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Author : Gilles Benichou
language : en
Publisher: Frontiers Media SA
Release Date : 2018-01-25
Allorecognition By Leukocytes Of The Adaptive Immune System written by Gilles Benichou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-25 with categories.
The term allorecognition refers to the series of mechanisms used by an individual’s immune system to distinguish its own cells and tissues from those of another individual belonging to the same species. During evolution, different cells and molecules of both innate and adaptive immune systems have been selected to recognize and respond to antigens expressed by allogeneic cells, but not autologous cells (alloantigens). This research topic focuses on allorecognition by lymphocytes of the adaptive immune system and its involvement in rejection or tolerance of allogeneic transplants. T and B cells recognizing alloantigens via specific receptors become activated and undergo proliferation and differentiation into different types of effector and memory cells. Allorecognition by lymphocytes occurs regularly during pregnancy upon trafficking of both maternal and fetal cells. In this setting, allorecognition triggers an alloresponse that is protective towards the fetus thus preventing abortion. Protective alloimmunity is mediated through cooperation between different lymphocytes and antigen presenting cells (APCs), as well as regulatory mediators and receptors. Likewise, certain transplants placed in organs and tissues called immune-privileged sites such as the eye, the central nervous system and the testis elicit protective rather than destructive adaptive immune responses. Therefore, under certain circumstances, allorecognition by regulatory lymphocytes (Tregs and Bregs) can lead to tolerance of alloantigens. In contrast, allorecognition by T cells in non-immune privileged sites and under inflammatory conditions leads to a destructive immune response. Indeed, after transplantation of most allogeneic organs and tissues, activation of pro-inflammatory T cells (TH1 and TH17), which recognize donor MHC proteins (direct pathway) or peptides derived from donor MHC and minor antigens (indirect pathway), leads to graft rejection. This inflammatory response leads to the differentiation of allospecific cytotoxic T cells as well as production of donor specific antibodies by B cells, both of which contribute to the destruction of the transplant. In this Research Topic, we describe the different pathways of allorecognition by T cells involved in allograft rejection, as well as the role of different antigen presenting cells and graft-derived microvesicles (exosomes) involved in this process. Another aspect of this Research Topic addresses the essential role of alloreactive memory T cells in allograft rejection and resistance to transplant tolerance induction in laboratory rodents, as well as non-human primates and patients. Indeed, it has become evident that laboratory mice display very few memory alloreactive T cells pre-transplantation, essentially due to the fact that they are raised in pathogen-free facilities. In contrast, primates display high frequencies of alloreactive memory T cells, either generated through prior exposure to allogeneic MHC molecules or via cross-reactivity with microbial antigens. We and others have provided ample evidence showing that this feature accounts for differences in terms of tolerance susceptibility between laboratory rodents and patients. This implies that further investigation of tolerance protocols in laboratory mice should be performed using “dirty mice” i.e., mice raised in non-sterile conditions. In summary, this Research Topic addresses key aspects of allorecognition by lymphocytes and alloantigen presentation by dendritic cells, and specifically how these processes shape our immune system and govern the rejection or tolerance of allogeneic tissues and organs.